In message <[log in to unmask]>, Eric Hindle
<[log in to unmask]> writes
>A Consultant Paediatrician colleague has just told me that she doesn't
>believe our alkaline phosphatase results, as she almost never sees a raised
>level in children with suspected vitamin D and calcium deficiency (causing
>rickets) subsequently demonstrated by lowish calcium and vitamin D levels
>and raised PTH, as well as other clinical and radiological signs.
>
>Our internal and external QC performace is exemplary and we will be
>reviewing our data to see if she is correct in her conclusion (and if she
>is we will stop doing them and save some money!).
>
>Any suggestions why we might not be seeing expected elevations in AP or is
>this something I should have known about?
>
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Beacuse it is a useless test for detecting low vitamin D. An audit of 2 years
work at SGH shows the AUC by ROC analysis to .55 = toss a coin
--
Paul Collinson
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