Following the QC comments regarding troponin.......
Biorad actually make a low level QC material. It is called Liquichek (TM)
Cardiac Marker Control LT.
Roche Elecsys cTnT
Level 1 = approx. 0.02 ug/L
Level 2 = approx. 0.31 ug/L
Level 3 = approx. 0.94 ug/L
This is in comparison to the normal liquichek with level 1 starting at
approx. 0.5 ug/L
Try this extremely long link to the Biorad product guide website.......
(trust me, it does work!)
http://www.bio-rad.com/B2B/BioRad/product/br_category.jsp?BV_SessionID=@@@@0
697027568.1062155141@@@@&BV_EngineID=ccccadcjellgjhmcfngcfkmdhkkdflm.0&categ
oryPath=%2fCatalogs%2fClinical+Diagnostics%2fQuality+Control%2fQuality+Contr
ol+Products%2fCardiac+Assessment+Controls%2fLiquichek+Cardiac+Markers+Contro
l+LT&searchStr=Liquichek+Cardiac+marker+Control+LT&cateName=Ordering+Informa
tion
____________________________________________________________________________
______________________
David C Gaze
Cardiac Research Scientist
Chemical Pathology
St George's Hospital Medical School
Cramer Terrace
Tooting
London SW17 0RE
Tel + 44 208 725 5878
Fax +44 208 682 0744
----- Original Message -----
From: Ballieux, B.E.P.B. (CKCL) <[log in to unmask]>
To: <[log in to unmask]>
Sent: Friday, August 29, 2003 10:42 AM
Subject: Re: TnT < 0.1 on elecsys 2010
> I have requested Bio Rad to incorporate a low level as mentioned below,
into
> their Cardiac Control, but I have never had respons from them. Maybe a
> concerted action would have any effect?
>
> Bart Ballieux
>
> Dr. B.E.P.B. Ballieux
> Clinical Biochemist
> Leiden University Medical Centre
> P.O.box 9600
> 2300 RC Leiden
> The Netherlands
> Tel:+3171-5262165/2278
> Fax: +3171-5266753
> email: [log in to unmask]
>
>
>
> -----Original Message-----
> From: Mohammad Al-Jubouri [mailto:[log in to unmask]]
> Sent: vrijdag 29 augustus 2003 11:29
> To: [log in to unmask]
> Subject: Re: TnT < 0.1 on elecsys 2010
>
>
> Thanks Paul and other responders
>
> So far I have reassuring replies like yours and other
> replies that advise exercising caution. The main issue
> is the lack of a commercial control at these low
> levels that one can use daily to report such low
> levels with some confidence. Some of you have used
> inhouse pooled sera for this purpose despite obvious
> reservations. What triggered this is a regional
> cardiologists risk stratification tool that gives
> various scores (1, 2, 3 and 4) for TnT levels of 0.04
> -0.06, 0.07 - 0.09, 0.10 - 0.19 and > 0.2 ug/L
> respectively. The tool also gives scores for clinical
> indicators (such as age, smoking, hypertension, DM,
> dyslipidaemia, LV dysfunction and ECG findings). A
> patient accumulating score > 6 is labelled as very
> high risk, 3 - 6 High risk and < 3 Low risk. Our local
> cardiologist couldn't say whether this scoring system
> is evidence based or best guess based.
>
> Kind regards
>
> Mohammad
>
> --- Paul Collinson <[log in to unmask]>
> wrote: > In message
> > <[log in to unmask]>,
> > Mohammad
> > Al-Jubouri <[log in to unmask]> writes
> >
> >
> > Depends on your precision profile. The assay is
> > precise down to at least
> > 0.05 (and 0.013 in our hands). All positive results
> > mean cardiac damage
> > but not always AMI
> >
> >
> > >Dear elecsys 2010 users
> > >
> > >Is it safe to report TnT levels of 0.03 - 0.09 ug/L
> > on
> > >this analyser? What sort of quality control at
> > these
> > >low levels people use? NEQAS has only distributed
> > few
> > >samples with TnT < 0.1 ug/L.
> > >
> > >Thanks
> > >
> > >Mohammad
> > >
> > >=====
> > >Dr. M A Al-Jubouri
> > >Consultant Chemical Pathologist
> > >
> >
> >________________________________________________________________________
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> > >community working in clinical biochemistry.
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> > be viewed
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> > --
> > Paul Collinson
>
> =====
> Dr. M A Al-Jubouri
> Consultant Chemical Pathologist
>
> ________________________________________________________________________
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community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
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