Dear Rakesh,
Greetings from Coastal Suffolk in England. The question you have posted
might be considered as a background question that addresses the patho
physiological aspects of an intervention although the final part of your
question compares the outcomes of various interventions. I hope the
information below will answer some parts of your question.
This is from the MCA (1999)
5.2 Pharmacokinetic properties
“Under normal conditions, the average half-life of albumin is about 19 days.
The balance between synthesis and breakdown is normally achieved by
feed-back regulation. Elimination is predominantly intracellular and due to
lysosome proteases.In healthy people, less than 10% of infused albumin
leaves the intravascular compartment during the first 2 hours following
infusion. As a result, the circulating volume will increase from 1 to 3
hours after administration”.
You can access heir document on line @
http://www.mca.gov.uk/inforesources/publications/albuminanx2.htm
Here is a FAQ on human albumin which talks about half life of human albumin.
http://www.albumintherapy.com/albumin/us/en/pdf/faq/All_FAQ.pdf
You might also find these reviews useful but I am not sure whether you will
have ready access to them.
Roberts JS, Bratton SL. Colloid volume expanders. Problems, pitfalls and
possibilities. Drugs 1998 May;55(5):621-30
Salmon JB, Mythen MG. Pharmacology and physiology of colloids. Blood Rev
1993 Jun;7(2):114-20
Wagner BK, D'Amelio LF. Pharmacologic and clinical considerations in
selecting crystalloid, colloidal, and oxygen-carrying resuscitation fluids,
Part 1. Clin Pharm 1993 May;12(5):335-46
This recent Cochrane review compares the various colloid substitutes.
Bunn F, Alderson P, Hawkins V. Colloid solutions for fluid resuscitation.
Cochrane Database Syst Rev 2001;(2):CD001319
Hope you find the above of some interest/?use.
Cheers & regards,
Badri
Dr.P.Badrinath M.D,M.Phil,(Epid)PhD(Cantab)DFPHM(UK),MPH(Distinc)
Specialist Registrar in PHM & Honorary Clinical Lecturer,
Suffolk Public Health Network & University of Cambridge,
PO Box 170, St.Clement's Hospital,
Ipswich IP1 4LA, UK.
Tel: 00 44 1473 329 570
Fax: 00 44 1473 329 090
http://myprofile.cos.com/badrishanthi
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