The big questions I see are:
Can RCTs handle complex intervention and complex evaluations?
Are they the best-suited for this?
Remember the Ca++ blocker trial (NORDIC??? or something, i pitched the
article) of nitrendipine or diltiazem, I can't remember, but they used a
method
that was supposed to simulate 'real life' practice. My first read on the
methods was that I thought it was a sham.
Second read is that it still is for a single-agent trial. As complexity
grows there may be more to it.
Dan
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