Dear colleague,
We have been running the Access AccuTnI assay for more than a
year now in a 24 hours x 365 days/year manner. It's specificity is
not 100%. For AMI at a cutoff of 0,5 ug/L it is claimed to be 94%
by Beckman Coulter. So one should expect false positives...
In february this year a posting was made in the MEDLAB listserver
that pointed to the article in the Kaohsiung Journal of Med Science
17:239-244, 2001 "Serial Changes of Cardiac Troponin I in Acute
Myoischemia Induced by Exercise Treadmill Test". The conclusion
of this article is: "serum cTn-I levels were found to increase to
some extent in one third of stable angina patients who have an
acute ischemic episode induced by treadmill exercise test".
In our opinion the Access AccuTnI assay is fast, sensitive and
shows good imprecision. This was also the conclusion of Uettwiller-
Geiger et al., Clin Chem 2002 48:869-76.
For QC we use BioRad Cardiac Markers Control LT at three levels
(which in our hands needs to be stored in a freezer instead of a
fridge for reasons of stability). We run 9 QC-samples a week, 3 of
each level. The imprecision found is well with the claims of
Beckman Coulter.
Best regards,
Christian
dr. C.H.H. Schoenmakers, European Clinical Chemist
Department of Clinical Chemistry, Elkerliek Hospital
P.O. box 98, 5700 AB Helmond
The Netherlands
(+)31-492-595555 (tel), (+)31-492-595691 (fax)
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