Dear list-members
I have received the following enquiry from a
clinical pharmacist:
"Like flecainide, propafenone is an
anti-arrhythmic which undergoes genetic polymorphism through CYP2D6.
About 5- 10% of the Caucasian are slow metabolisers and are at risk of
toxicity with standard dosing. We have one such patient in hospital at
present and it would be most helpful is we could meaure levels.
Propafenone is becoming increasingly popular as
an anti-arrhythmic and given the toxicity associated with higher levels
and a significantly high vulnerable patient group, I beleive there is a
good argument for someone to offer this test."
Can anyone offer a lab which can measure this
drug in blood/plasma, please?
Can anyone offer evidence that blood levels are
meaningful/useful?
Dr Chris Lovell-Smith
Clinical Leader and Chemical Pathologist
Dunedin Hospital
New Zealand
######################################################################
Attention:
This e-mail is privileged and confidential. If you are not the
intended recipient please delete the message and notify the sender.
Any views or opinions presented are solely those of the author.
######################################################################
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|