Yes placental AP can increase fairly dramatically in complicated pregnancy.
You don't need anything very high-tech here.
Immerse the sample in a water bath at 65oC for 15 minutes. Bone and Liver AP
will be all but obliterated, but placental AP won't.
Some old refs for you
Hunter, R. J., Pinkerton, J. H. M., and Johnston, H., Serum
placental alkaline pbosphatase in normal pregnancy and preec-
lampsia. Obstet. Gynecoi. 36,536-546 (1970).
Aleem, F. A., Total and heat-stable serum alkaline phoepbatase
in normal and abnormal pregnancies. Obstet. GyneeoL 40,163-172
(1972).
Aubrey Blumsohn
Senior lecturer in Metabolic Bone Disease
University of Sheffield
----- Original Message -----
From: "Ian McFarlane" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Tuesday, July 30, 2002 6:11 PM
Subject: ALP in pre-eclampsia
> We have a 38/40 lady with pre-eclapmsia and and ALP of 2400U/L in the face
> of normal LFT (inc gammaGT). Does anyone have any information on ALP
levels
> in this situation?
> There is tiny bit of information in The Effects of Disease on Clinical
> Laboratory Tests about elevated levels in pre-eclamptic pregnancies and
that
> high levels may indicate placental as well as hepatic damage. Does anyone
> have any more information? I can't get at the primary sources quoted for
> these facts.
> Also would people recommend Alk Phos isoenzymes in this situation?
>
> Thanks,
>
> Ian McFarlane
> Addenbrooke's Hospital
> Cambridge
>
>
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