From the formula for calculating %saturation of transferrin :-
x x iron (umol/l) divided by transferrin (g/l)
I would be interested in knowing what values for x labs use. I ask this as I
have encountered 3 different values in the 3 different labs I have worked
in.
These are
3.83 which assumes a Mwt for transferrin of 76,500
4.0 which assumes a Mwt of 80,000
4.5 which assumes a Mwt of 90,000
I realise the problem is in the approximation of the molecular weight of
transferrin but assume it would aid our users (and me) if we all made the
same assumption.
For those unfamiliar with the calculation and using the 2nd of the
estimates:-
1umol or 0.08g transferrin maximally combines with 2umol Iron.
Therefore 1g transferrin can combine with (1/0.08)x2 = 25umol iron
Therefore TIBC umol/l = Transferrin g/l x25
Therefore %saturation = (iron umol/l / transferrin g/l x 25) x 100
= iron x 4 / transferrin
Rachel
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