Is this in an child or in an adult? Sometimes dopamine is the only
catecholamine that is detectable in neuroblastoma (especially the
undifferentiated forms):
J Pediatr Surg 1995 Sep;30(9):1317-8
Failure to detect dopaminergic neuroblastoma in a mass-screening system.
Naito H, Takeda T, Hanai J.
Department of Surgery, Sapporo National Hospital, Hokkaido Cancer Center,
Japan.
Dopaminergic neuroblastoma comprised 12% of the patients under 1 year of
age, and 83% of the older ones. Seven cases were missed by the
mass-screening system performed at age 6 months and were detected after 16
months. Three of these advanced cases were positive only for dopamine. These
findings supports our second mass-screening system using dopamine evaluation
at age 14 months.
PMID: 8523234 [PubMed - indexed for MEDLINE]
Acta Paediatr 1994 Jan;83(1):88-92
Interpretation of random urinary catecholamines and their metabolites in
neuroblastoma.
O'Meara A, Tormey W, FitzGerald RJ, Fitzgibbon M, Kenny D.
Children's Research Centre, Our Lady's Hospital, Crumlin, Dublin, Ireland.
This study reports experience in the estimation of urinary catecholamines
(uCATs) and their metabolites in the diagnosis and follow-up of
neuroblastoma. Random urine samples were assayed for dopamine, noradrenaline
and adrenaline, together with their metabolites 4-hydroxy 3-methoxymandelic
acid (HMMA) and homovanillic acid (HVA), using HPLC with electrochemical
detection. Twenty of 21 patients had elevation of one or more uCATs
metabolites at diagnosis. Patients were monitored serially from diagnosis
and, in those patients who had delayed resection of primary tumour (n = 13),
particular attention was paid to levels at the pre-surgical evaluation as an
indicator of persistence of viable disease at the time of surgery; dopamine
proved to be the most accurate indicator of persistent disease at this time.
Five of these patients developed recurrent disease, 4 of whom had elevation
of two or more uCATs metabolites at the time of relapse. Several conclusions
can be drawn from this study: (a) results for HMMA, HVA and dopamine in
random urine samples will detect all but the most biochemically immature or
inert tumours; (b) dopamine may be the most reliable indicator of persistent
disease and (c) noradrenaline and adrenaline measurements were of little
benefit. As results are expressed in relation to urinary creatinine,
excretion of which may be affected by dietary protein and is therefore not
constant, borderline results should be repeated.
Dr.Ir. B.E.P.B. Ballieux
Klinisch Chemicus
Medial, medisch-diagnostische laboratoria
Locatie Spaarne Ziekenhuis
Händellaan 2, 2102 CW Heemstede
Tel 023-5141516 sein 4739
Fax 023-5141208
----- Original Message -----
From: <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, July 01, 2002 1:50 PM
Subject: DOPAMINE
> What is the significance of a raised urinary dopamine (in three 24 hr
collections)
> when both adrenaline and noradrenaline normal in all 3?
>
> Thanks
>
> Rob L
> Dr Robert Lord
> Department of Clinical Biochemistry
> Rotherham District General Hospital
> Moorgate Road
> Oakwood
> Rotherham
> S60 2UD
>
> Tel 01709 820000
>
> E mail [log in to unmask]
>
> ------ACB discussion List Information--------
> This is an open discussion list for the academic and clinical
> community working in clinical biochemistry.
> Please note, archived messages are public and can be viewed
> via the internet. Views expressed are those of the individual and
> they are responsible for all message content.
>
> ACB Web Site
> http://www.acb.org.uk
> List Archives
> http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
> List Instructions (How to leave etc.)
> http://www.jiscmail.ac.uk/
>
> _______________________________________________________________________
> Dit inkomende bericht is gecontroleerd op alle bekende virussen voor het
Spaarne Ziekenhuis door KPN IV-Scan, powered by MessageLabs.
> Voor informatie: http://www.veiliginternet.nl
> _______________________________________________________________________
_______________________________________________________________________
Dit uitgaande bericht is gecontroleerd op alle bekende virussen voor het Spaarne Ziekenhuis door KPN IV-Scan, powered by MessageLabs.
Voor informatie: http://www.veiliginternet.nl
_______________________________________________________________________
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|