Trevor
The study you quoted in your message compared CK and urine
myoglobin in patients following major surgery. It is not surprising to me
that after hacking the muscles around that CK is raised but myoglobin
not detected in the urine. However this is not the equivalent of crush
injuries or severe burns, which are the clinical situations most likely to
be associated with significant myoglobinuria.
I agree with most other correspondents that the measurement of
myoglobin in urine is usually not clincally helpful and that other factors
are involved in the renal failure. Nevertheless I have great difficulty in
dissuading my clinical colleagues from requesting it. We do offer CK as
the front line test.
Mike Addison Dr G.Michael Addison
Royal Manchester Children's Hospital
Pendlebury
Manchester M27 4HA
United Kingdom
Tel 0161-727-2250(AM)or 0161-220-5342(PM)
FAX 0161-727-2249
Email [log in to unmask]
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