Dichloromethane exposure?
Robert Forrest
> -----Original Message-----
> From: This list is an open discussion list for the academic community
> working in [mailto:[log in to unmask]]On Behalf Of Graham
> Jones
> Sent: 18 February 2002 05:24
> To: [log in to unmask]
> Subject: Carboxyhaemoglobin elevations
>
>
> Dear Colleagues,
>
> Another query from down under!
>
> I have had an enquiry about elevated carboxyhaemoglobin levels in
> a patient
> with venous thromboembolic disease. The patient is a smoker (light) with
> recent pulmonary embolus. Using a breath measuring device for carbon
> monoxide the physician found an elevated level which apparently translates
> to about 30% COHb. A formal measurement by co-oximetry gave about
> 10% after
> over 24 hours off the ciggies.
>
> My list of causes of elevated carboxyHb (due to High CO) include cigarette
> smoking, smoke inhalation and haemolysis. Regarding haemolysis the
> literature concentrates on this effect in neonates but I am interested an
> anyone's experience in adults (we have seen a level of 4.8% in a pyruvate
> kinase deficient patient). Regarding smoke exposure, as it is Australia in
> the summer, it seems unlikely that heating systems could be implicated.
>
> Any additions to this list of causes of elevated CO and/or carboxyHb,
> particularly with regard to thromboebolic disease, would be most welcome.
>
> Many thanks,
>
> Graham
> Graham Jones
>
> Staff Specialist in Chemical Pathology
> St Vincent's Hospital, Sydney
> Victoria St, Darlinghurst, 2010
> NSW, Australia
> Ph: (02) 8382-2170 Fax (02) 8382-2489
> [log in to unmask]
>
>
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