CF patients usually are on treatment with "Pancreatine", a bovine pancreatic
enzyme preparation. In the laboratory of the Sophia Children's Hospital
(Erasmus Medical Centre Rotterdam) we used to follow those patients with an
enzymatic chymotrypsin assay. This measures both bovine and human
chymotrypsin enzymatic activity. Remaining pancreatic function can be
assessed using a fecal elastase ELISA, which doesn't crossreact with the
bovine elastase in the "Pancreatine"
Bart Ballieux
Dr.Ir. B.E.P.B. Ballieux
Klinisch Chemicus
Medial, Locatie Spaarne Ziekenhuis
Händellaan 2, 2102 CW Heemstede
Tel +3123-5141516 sein 4739
Fax +3123-5141208
----- Original Message -----
From: "Trevor Gray" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Friday, July 05, 2002 11:16 PM
Subject: Monitoring cystic fibrosis
> Dear colleagues,
>
> One of my colleagues has a patient with CF who is already on
> supplemental enteral feeding with 1500+ calories per day who is losing
> weight. Infection appears to be under control, and there are no
> clinical signs of problems elsewhere. He has asked for a faecal fat as
> a measure of fat absorption, which we stopped doing years ago. I am
> aware that other CF units use faecal fats for this purpose. Does anyone
> have a good method for assessing this. My assertion that if the patient
> has normal stools, fat malabsorption is unlikely, has fallen on deaf
> ears. I appreciate that other indices usually used for malabsorption
> are difficult to interpret in cystic fibrosis. The patient does have
> impaired glucose tolerance so insulin treatment could make a difference,
> but they would like to know if there is an absorption problem.
> Trevor
> --
> Trevor Gray
> Dept. of Clinical Chemistry,
> Northern General Hospital,
> Sheffield S5 7AU
>
> 0114 271 4309
>
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