On Fri, 3 May 2002 08:46:05 +0100, Stephen Davis <Stephen.Davis@PR-
TR.WALES.NHS.UK> wrote:
>The WHO guidelines for the performance of the oral glucose tolerance test
>requires the glucose load to be given in a volume of 250 - 300 mL. To give
>the equivalent of 75 g anhydrous glucose using Lucozade requires a volume
of
>394 mL. GSK quote the 1999 WHO Report "Definition, Diagnosis and
>Classification of Diabetes Mellitus and its Complications" in their flyer
>but fail to mention Lucozade's shortcomings for the test!
>
>Steve Davis
>Principal Biochemist
>Department of Clinical Biochemistry
>Royal Glamorgan Hospital
>Ynysmaerdy
>PONTYCLUN
>CF72 8XR
>
>Tel : +44 (0)1443 443357
>Fax: +44 (0)1443 443355
>
>> -----Original Message-----
>> From: Gray Malcolm [SMTP:[log in to unmask]]
>> Sent: Thursday, May 02, 2002 3:14 PM
>> To: [log in to unmask]
>> Subject: Re: Lucozade and GTT changed formulation
>>
>> Here is the flier from GSK relating to the change to the Lucozade
>> formulation, for any colleagues who were not aware of the change.
>>
>> In Word format: <<gttsheet02.doc>>
>>
>> In Acrobat <<gttsheet02.pdf>>
>>
>> When I checked up on the change, I asked the Nutrition department at GSK
>> to
>> make sure that adverts for these changes are published in the ACB news
>> sheet, so that those concerned with the testing wouldn't have to hear
from
>> GP colleagues etc. Haven't seen anything yet, but you never know.
>>
>> Malcolm Gray
>> Clinical Biochemistry
>> St. Bartholomew's Hospital
>> West Smithfield
>> LONDON EC1A 7BE
>> Tel: 020 7601 8253
>> Mobile 0794 100 7290
>>
>>
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>> << File: gttsheet02.doc >> << File: gttsheet02.pdf >>
>
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There are two papers published on this subject:
Dilution of the 75-g Oral Glucose Tolerance Test (OGTT) for Diabetes
Increases Postprandial Glycemia.
Sievenpiper, J.L., S.F. Welch, D.J.A. Jenkins, R.G. Josse, and V. Vuksan.
Dilution of the 75 g oral glucose tolerance test (OGTT) for diabetes
increases postprandial glycemia. FASEB J. 13(5): A273, 1999.
Sievenpiper, J.L., D.J.A. Jenkins, R.G. Josse, and V. Vuksan. Dilution of
the 75 g oral glucose tolerance test increases postprandial glycemia:
Implications for diagnostic criteria. CMAJ 162: 993-996, 2000.
Summary of the results:
Different dilutions of an oral glucose tolerance test (OGTT) were tested to
determine if they had variable effects on glycemia (blood-sugar levels).
Ten subjects with normal glucose tolerance were given oral glucose (75 g)
diluted in 300 ml, 600 ml, or 900 ml of fluid. The elevations in blood
glucose were found to be higher with the 900 ml dilution but were not
different between the 300 ml and 600 ml dilutions.
Therefore giving 394mls instead of 300mls. should have no significance
in the outcome of the test.
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