We are presenting a case like this at FOCUS when the TnT was raised in dermatomyositis ( we do have many others). This is not unexpected as there is cardiac involvement .A positive TnT may be a marker for a poor outcome in these patients. We propose the release is from the inflammatory process rather than ischaemia, all these patients have normal echos and ecg's. They don't normally present with chest pain so should not get on a "? MI" pathway. We should encourage Dr's to treat the patient and not the numbers.
Mr E M Kearney, MSc, MCB, FRCPath,
Consultant Clinical Biochemist,
Department of Clinical Biochemistry,
East Kent Hospitals NHS Trust,
Queen Elizabeth the Queen Mother Hospital,
St Peters Road,
Margate,
CT9 4AN
Phone 01843 234424
E mail [log in to unmask]
>>> "Firth, Gary" <[log in to unmask]> 03/20/02 05:04pm >>>
Whilst putting together a presentation on troponin T for our medical staff I
have come across several papers that indicate that Troponin T (but rarely I)
is raised in some cases of polymyositis and dermatomyositis.
The suggestion made in at least one paper (Clin Chim Acta 2001; 306:27) is
that this may be due to release of cTnT from skeletal muscle. Does anyone
have any evidence to support or refute this suggestion or is this indeed the
exception that proves the rule?
Gary Firth
Princess Royal Hospital
Sussex
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