Dear All,
We have been discussing a young (my age - upper 40s) patient with a
cholesterol greater than 10mmol/l who is prescribed 80mg simvastatin but his
cholesterol is not falling by the expected amount. We will be seeing him to
ascertain whether he is compliant but a question that was raised concerns
"resistance" to a statin formulation.
At 80mg, we would expect a raised total CK. The question is: does the
magnitude of a rasied CK correlate with the magnitude of the effect of the
treatment on cholesterol levels? ie, is a higher CK associated with a
diminished cholesterol-lowering effect
I've had a look at PubMed but its difficult to phrase the search adequately.
Has anyone come accross any published studies?
Many thanks.
Gareth
Gareth Davies
Senior Clinical Biochemist
Wrexham Maelor Hospital
Wrexham LL13 7TD
UK
01978 725345
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