In a paper by Goldstein et al (Diabetes 1997:46 (suppl.1):8A) the
relationship between HbA1c and various measures of mean blood glucose in the
DCCT (1439 subjects with 26,043 matching HbA1c and blood glucose profile
pairs) was studied. They found the following correlations: pre-breakfast
r=0.67; pre-lunch r=0.71; pre-dinner r=0.74; bedtime r=0.74; four-point
profile r=0.81; seven-point profile r=0.81. The data showed that with
increasing HbA1c mean fasting and, to a lesser extent, four-point (mean of
pre-meal and bedtime) plasma glucose progressively underestimated HbA1c
compared to the seven-point profiles. From these data it was concluded that
patients who maintain mean plasma glucose level (seven-point) below
approximately 9.7 mmol/L ( 175 mg/dL) will achieve the ADA-recommended
HbA1c-goal of <7%.
Hope this helps,
Henne Kleinveld
Dr. H. Kleinveld
Department of Clinical Biochemistry and Haematology
Atrium Medical Center
Heerlen
The Netherlands
----- Original Message -----
From: Dr Pat Twomey <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, November 19, 2001 4:58 PM
Subject: HbA1c
> A quick question - does HbA1c correlate best with the glucose
> Area Under the Curve or is the correlation with Fasting Plasma
> Glucose or peak plasma glucose better?
>
> Many thanks,
>
> Pat Twomey
>
> Dr. Pat Twomey,
> Department of Clinical Biochemistry,
> Royal Infirmary, Edinburgh EH3 9YW.
> tel: 0131-5362704
> fax: 0131-5362758
>
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