Many thanks to everybody who replied to my original
query. To summarise:
1. There is good scientific basis for measuring TPMT
before initiating azathioprine or mercaptopurine
therapy.
2. It is too much to ask for a prospective double
blind trial before approving clinical need for TPMT
measurement as most of our assays do not have such a
grade A evidence behind them.
3. There needs to be more laboratories capable of TPMT
measurement.
regards.
=====
Dr. M A Al-Jubouri
Consultant Chemical Pathologist
Whiston Hospital
Prescot
Merseyside L35 5DR
UK
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