Assuming there is no analytical interference, the high phosphate may be the
result of acute necrosis of tumor (and healthy) cells from chemotherapy.
Although total calcium is within reference limits, ionized calcium would be
markedly low due to complexing by phosphate and this may have actually
triggered or contributed to the cardiac arrest.
Salvador F. Sena, Ph.D., DABCC
Associate Medical Director, Clinical Chemistry
Danbury Hospital
Danbury, CT 06810 USA
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> -----Original Message-----
> From: Derek Pledger [SMTP:[log in to unmask]]
> Sent: Friday, October 26, 2001 11:20 AM
> To: [log in to unmask]
> Subject: Hyperphosphataemia
>
> 59 year old lady with metastatic Ca breast admitted with asthmatic attack.
> PO4 5.63 mmol/L, urea 10.9 mmol/L, creat 231 umol/L, ALT 1024 iu/L
> (0-37). Ca, ALP, electrolytes all normal.
> She had a cardiac arrest within minutes of the blood sample being
> collected. Other than in patients who have been given PO4 enemas, I
> cannot
> recall seeing this level of PO4 in someone with relatively normal renal
> function. Does anyone have any ideas?
>
> Derek Pledger
> Dept. Clinical Biochemistry
> Ipswich Hospital
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