Is this a one off result? Is it persisting over a long
period of time? What is the ALP isoenzyme pattern?
With very high ALP, it is worth considering transient
hyperphosphatasaemia, where abnormal sialylation of
ALP results in decreased enzyme clearance.
regards.
--- Peter Stromberg <[log in to unmask]>
wrote: > We have a thin 6 year old girl with Downs
syndrome
> who has an alk phos of 11,670 u/l ( reference range
> for growing child <900 .PNP methodology.). It is
> likely that she has coeliac disease. All her other
> LFT,s are normal.I can just remember seeing this
> before in the Lancet where it was described in
> ?Japan as an inherited anomaly of no clinical
> consequence.Anybody know anything about this
subject?
=====
Dr. M A Al-Jubouri
Consultant Chemical Pathologist
Whiston Hospital
Prescot
Merseyside L35 5DR
UK
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