We have a thin 6 year old girl with Downs syndrome who has an alk phos of 11,670 u/l ( reference range for growing child <900 .PNP methodology.). It is likely that she has coeliac disease. All her other LFT,s are normal.I can just remember seeing this before in the Lancet where it was described in ?Japan as an inherited anomaly of no clinical consequence.Anybody know anything about this subject?
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