Re RCTs that changed medical practice
I would like to propose
International PHVD Drug Trial Group(1998) International randomised
controlled trial of acetazolamide and frusemide in post-haemorrhagic
ventricular dilatation in pregnancy. Lancet 352, 433-440
It is relatively recent, but my understanding from several paediatricians I
have spoken to is that they have changed their practice.
I was the statistician reporting to the DMEC and it raised severe problems
about when to stop a major international trial, where the treatment effect
appears opposite to that expected, but when stopping early may reduce the
impact of the trial and so make it less likely to change medical practice.
Mike
Professor Mike Campbell
Institute of Primary Care and General Practice
Community Sciences Centre
Northern General Hospital
Sheffield S5 7AU
Tel 0114 271 5919
Fax 0114 242 2136
e-mail [log in to unmask]
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