Professor Per Andersen (Department of Biostatistics, University of Copenhagen)
will be giving the following seminar at the Institute of Public Health
on Friday 7th of April. The seminar starts at 1 pm in the large seminar room.
Everyone is welcome.
Title: COMPETING RISKS ANALYSIS OF THE CASE-COHORT DESIGN.
Abstract
The case-cohort design has been put forward as an alternative
design in epidemiological follow-up studies which is less expensive
than a full-scale cohort study. In this design, all cases are
assembled together with a randomly selected sub-cohort which is
then used as a comparison group, one advantage being that the same
sub-cohort may serve as a comparison group for a number of different
case series. However, the fact that all case groups are compared with
the same sub-cohort creates a correlation between estimated effects of
exposures on the different outcomes. This asymptotic correlation is
derived using martingale central limit theory by studying competing
risks data sampled using a case-cohort design. In a Monte Carlo
simulation study, effects on the correlation of factors as number
of cases and size of sub-cohort is studied.
Daniela De Angelis
MRC Biostatistics Unit Tel: + (0)1223 330390
Institute of Public Health
Robinson Way Fax: + (0)1223 330388
Cambridge
CB2 2SR Web: www.mrc-bsu.cam.ac.uk
United Kingdom
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|