The association with rhabdomyolysis is certainly recognised. The following
references might help.
Trimarchi H, Gonzalez J, Olivero J.
<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis
t_uids=10396001&dopt=Abstract> Hyponatremia-associated rhabdomyolysis.
Nephron. 1999;82(3):274-7.
Rizzieri DA.
<http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis
t_uids=7731258&dopt=Abstract> Rhabdomyolysis after correction of
hyponatremia due to psychogenic polydipsia. Mayo Clin Proc. 1995
May;70(5):473-6.
Steve Davis
Principal Biochemist
Department of Clinical Biochemistry
Royal Glamorgan Hospital
Ynysmaerdy
PONTYCLUN
CF72 8XR
Tel: (0)1443 443357
Fax: (0)1443 443355
-----Original Message-----
From: TICKNER TREVOR (RM1) Norfolk and Norwich NHS Trust
[SMTP:[log in to unmask]]
Sent: Wednesday, October 25, 2000 2:50 PM
To: [log in to unmask]
Subject: Hyponatraemia and raised CK
Male Caucasian farmer aged 37 presented with confusion and agitation.
On admision sodium 119 mmol/l, urea 1.4 mmol/l, K 3.6 mmol/l, serum
osmolality 251mmol/l, urine osmolality 279 mmol/l, urine Na 85 mmol/l, K 16
mmol/l. Mild ECG changes CKMB (rate) 49 total CK 2089 troponin I <0.1.
Treated 1.8% w/v saline. Na returned to normal over 2 days CK rose to 44600
after 24 hours and >134,000 after 2 days.
No other active treatment. Ck returned to 9750 prior to discharge after 1
week.
Only known chemical contact 'BRESTAN 60' (Fentin acetate, Maneb and
surfactant).
Any comments would be appreciated especially on any relationship between the
hyponatraemia and raised CK.
Trevor Tickner
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