In my opinion this elevated CK is due to muscle exertion. In the past I have
seen a CK of about 4000 U/L (ref. <120) in a male lab.worker, who appeared
to start his football training for the new season after the summerholidays.
The day after we took plasma samples for determining reference values. When
we saw this elevated CK we have running further tests and found also a
strongly elevated aldolase. CK-MB was not elevated (i.e. <6% of total CK by
immunoinhibition). This male is still in apparently good health working with
us.
Dr. A. J. Bakker, Klinisch chemicus,
St. Klinisch Chemisch Laboratorium,
Postbus 850,
8901 BR LEEUWARDEN.
Tel.: 058-2888444
Fax: 058-2882227
E-mail: [log in to unmask]
> -----Oorspronkelijk bericht-----
> Van: Jonathan Kay [SMTP:[log in to unmask]]
> Verzonden: woensdag 5 april 2000 17:00
> Aan: [log in to unmask]
> Onderwerp: High plasma CK activity in a patient eating creatine
>
> We have a c30 year old patient who is a bodybuilder and eats large
> supplements of creatine and high-protein preparations.
>
> He has had a plasma CK activity up to 1800 u/L, when his plasma AST was
> 91 u/L, GGT 15 u/L, CK-MB 32 u/l (inhibition assay, not mass). Plasma
> creatinine is about 100 micromol/L.
>
> He denies im injections and there are no abscesses etc.
>
> I would very much appreciate suggestions as to why his plasma CK
> activity is so high:
> ... is there any known effect of eating creatine?
> ... due to muscle exertion (we see surprisingly high CK activity in
> long-distance runners)
> ???
>
> Dr Jonathan Kay
> University of Oxford
>
>
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