Dear Dr. Collinson
Data are available linking TnI level and infarct size,
to name few:
1. Mair et al. Cardiac TnI release correlates with MI
size. Eur J Clin Chem Clin Biochem 1995; 33: 869-72.
2. Tanaka et al. Serum levels of TnI and TnT in
estimating infarct size. Coron Artery 1997; 8:433-9.
3. Apple et al. Asssessment of LV function using serum
TnI following MI. Clin Chim Acta 1998; 272:59-67.
--- Paul Collinson <[log in to unmask]>
wrote: > In message
> <[log in to unmask]>,
> Mohammad
> Al-Jubouri <[log in to unmask]> writes
> >Dear all
> >I would welcome your views on timing of samples for
> a
> >single TnI measurement for the assessment of acute
> >coronary syndrome. Most laboratories have adopted
> 12 h
> >post admission whether they measure TnI or TnT. If
> we
> >are aiming at measuring peak troponin levels, which
> >correlate better with infarct size and prognosis,
> then
> >this timing may not always hit the peak level. From
> my
> >limited experience of measuring TnI in acute MI
> >patients admitted to our CCU, it is usually cardiac
> >enzyme 2 or 3 which show the peak TnI level
> coinciding
> >with peak CK levels (NB: in our Hospital CCU, CK
> and
> >AST are measured at 8hrly intervals). Therefore
> 16-18
> >hours post admission timing may be more appropriate
> in
> >this regard. Alternatively, we should probably aim
> at
> >getting two troponin results taken 8 hours apart,
> >which will give us a slope from which we can
> estimate
> >infarct size. Also having a second sample for
> troponin
> >will provide a saftey net should any thing goes
> wrong
> >analytically or otherwise with the first sample.
> The
> >cost of course will double. Your expert opinion on
> >this matter is greatly appreciated.
> >
> >=====
> >Dr. M A Al-Jubouri
> >Consultant Chemical Pathologist
> >Whiston Hospital
> >Prescot
> >Merseyside L35 5DR
> >UK
> >
> >__________________________________________________
> >Do You Yahoo!?
> >Yahoo! Photos -- now, 100 FREE prints!
> >http://photos.yahoo.com
>
> I am not aware of data for peak I vs infarct size.
> We found the 12-24 hours
> sample optimunn (and practical) to predict ejection
> fraction
>
> --
> Paul Collinson
=====
Dr. M A Al-Jubouri
Consultant Chemical Pathologist
Whiston Hospital
Prescot
Merseyside L35 5DR
UK
__________________________________________________
Do You Yahoo!?
Yahoo! Photos -- now, 100 FREE prints!
http://photos.yahoo.com
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|