Lars Eikvar, Ullevaal university hospital, Oslo, NORWAY wrote:
> In our lab. we have been measuring paracetamol with the FPIA method on TDX
> instruments for more than 10 years. Currently however, we are looking at
> transferring this analysis to a Cobas Integra. This instrument offers only
> an enzymatic method (aryl acylamidase) for paracetamol.
> Are there specific problems related to quality control materials for this
> assay? In the EQA program for LabQuality (Finland) in which we participate
> with the FPIA method, the enzymatic methods give significantly lower
> results.
In the UK NEQAS for Salicylate & Paracetamol, which uses liquid human
serum specimens, the TDX users also show a positive bias relative to other
(enzymic) procedures. However, these comments are based on two TDX
participants only and the bias is small (0.5% and 3%).
I hope this is helpful
Dr David Bullock
Director, Wolfson EQA Laboratory
P O Box 3909, Birmingham B15 2UE, U K
FAX: 0121 414 1179 [+44 121 414 1179]
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