Suppression of TSH secretion can be induced by several
factors including dopamine, dopamine agonists (like
bromocriptine and cabergoline), corticosteroids, IL-1,
TNF-alpha and somatostatin. TSH suppression by these
factors, somehow, does not usually result in secondary
hypothyroidism.
Regards
Dr. M A Al-Jubouri
Whiston Hospital
--- "Everitt, Tony"
<[log in to unmask]> wrote:
> I would appreciate some advice on the following:
>
> 74 year old female with Parkinson's disease. On
> Sinemet (levodopa and
> carbidopa). The carbidopa blocks peripheral
> degradation of levodopa to
> dopamine, thus decreasing the perpherial
> side-effects of dopamine such as
> nausea and vomiting. Carbidopa does not cross the
> blood-brain barrier.
>
> c/o tiredness and weight gain (2 stone in last 12
> months).
>
> Her biochemistry:
>
> TSH 0.1 (0.4 - 5.0)
> Free T4 11.7 (12.0 - 23.0)
> Free T3 4.0 (4.0 - 7.8)
>
> Random Cortisol 179
> Prolactin 473
> LH 25
> FSH 71
>
> Is it possible that the dopamine produced is having
> a suppressive effect on
> her TSH secretion?
>
> Tony Everitt
> Basildon Hospital
>
>
>
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=====
Dr. M A Al-Jubouri
Consultant Chemical Pathologist
Whiston Hospital
Prescot
Merseyside L35 5DR
UK
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