A haematology colleague had an almost identical case as you describe here.
There are known associations between high ferritin levels and malignancy,
particularly renal cell carcinoma ("Serum Ferritin as a clinical marker for
renal cell carcinoma", Urol Int 1999;62(1):21-5). In our patient further
investigation revealed she had a large renal cell carcinoma.
Frank Murphy
Harefield Hospital
-----Original Message-----
From: Huw Griffiths [SMTP:[log in to unmask]]
Sent: 28 November 2000 18:06
To: [log in to unmask]
Subject: L/H-type Ferritin
One of our physicians has been investigating a 51-year old woman
for possible iron overload. Serum Ferritin 2025 mcg/L (15-233).
However,
serum Fe/TIBC normal, LFTs normal, Liver biopsy & genetic studies
not consistent with haemochromatosis. He has asked if L and H-type
serum ferritin concentrations can be measured. He is considering
an autosomal dominant condition in which hyperferritinaemia is
associated
with cataract formation, in which ferritin is composed mostly of
the L-type subunits. Can anyone help/advise on the determination
of ferritin H/L subunits?
Thanks
--
Huw Griffiths
Huddersfield Royal Infirmary UK
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