Look at these interesting references, where 5 and 20 g creatine is given for
several days. These doses had no effect on creatinine or CK levels.
Ropero-Miller JD, Paget-Wilkes H, Doering PL, Goldberger BA. Effect of oral
creatine supplementation on random urine creatinine, pH, and specific
gravity measurements. Clin Chem 2000 Feb;46(2):295-7
Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading
increases fat-free mass, but does not affect blood pressure, plasma
creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000
Feb;32(2):291-6
Uttam Garg, PhD, DABCC
Associate Professor
Director of Clinical Chem & Toxicology and
Co-Director of Biochem Genetics Labs
Children's Mercy Hospital
Kansas City, MO 64108
Phone: 816-234-3803
Fax: 816-234-3794
> -----Original Message-----
> From: James Miller [SMTP:[log in to unmask]]
> Sent: Friday, April 07, 2000 6:52 AM
> To: [log in to unmask]; [log in to unmask]
> Subject: Re: Creatine and CK
>
> It will be interesting to find out whether ingestion of creatine increases
> CK in the absence of beginning or extreme exercise. However, no one has
> mentioned or asked whether ingestion of creatine increases creatinine. Of
> course, creatinine is a by-product of creatine and, if my memory still
> serves me, I believe this is a non-enzymatic conversion so it may not
> depend on creatine actually getting into muscle cells. Anybody noticed
> increased creatinine in patients taking creatine?
> -Jim
>
> James J Miller, Ph.D., DABCC
> Associate Professor
> Dept. of Pathology & Laboratory Medicine
> University of Louisville
> Louisville, KY 40292
>
> 502-852-1179
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