We have noted similar problems with female testosterone measurements on the
Immulite 2000. Our current QC material is Randox Immunoassay control which at
level 1 gives a reading of approximately 5.5.
> We currently use Centaur for male and female testosterone, but lack a
> normal/low female testosterone control level. The ligand controls supplied
> by Bayer only go as low as 3.6 nmol/l. We changed from DPC CAC testosterone
> to Centaur, and note an increase in the number of female elevated
> testosterone, i.e around 3.8-4.0 nmol/l, so either we missed females before,
> or have the wrong reference range (0.2-3.0) or we have interfering
> substances. Theorists will say we should confirm with extraction methods,
> but who is doing that nowadays? We know our CVS at the low end are about
> 15%, and so feel a lower control would be helpful. Has anyone located such a
> control?
>
Dr David G Williams
FRCPath
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