I am not sure of the origin of the >10x CK level. Does anyone know?
Of course patients may develop symptoms with or without CK rise. Equally
they may have a rise in Ck without being symptomatic. It tend to withdraw
treatment if symptoms are unpleasant. If ck level is raised then I tend to
repeat within a fortnight. In many cases the rise is related to exercise the
day before. I advice stopping medication if the level continue to rise.
There is a lesson of the week in the BMJ from about 5 years back on the
pitfall of starting statins without checking CK/TFTs.
So depsite of the data sheet/BNF recommendation I think many people would
not wait until the CK is >10x !
Ahmed Waise FRCP FRCPath
Consultant Chemical Pathologist
Friarage Hospital, Northallerton,
North Yorkshire DL6 1JG, UK.
Tel 01609 763030
Fax 01609 764632
E Mail [log in to unmask]
> ----------
> From: Fleming, Simon - RCHT[SMTP:[log in to unmask]]
> Reply To: Fleming, Simon - RCHT
> Sent: 03 March 2000 08:13
> To: 'Peter Stromberg'; [log in to unmask]
> Subject: RE: STATINS AND CK
>
> I agree with Dermot, if patients have symptoms we sometimes have to
> reduce dose or withdraw. In those who are asymptomatic I tend to get a bit
> twitchy when the CK rises above 1000 iu/l or an ALT > 100 iu/l. Also
> beware of hypothyroidism this can exacerbate the myopathy with spectacular
> effects.
>
> Simon Flemming
> Royal Cornwall Hospital
>
> -----Original Message-----
> From: Peter Stromberg [mailto:[log in to unmask]]
> Sent: Thursday, March 02, 2000 15:32
> To: [log in to unmask]
> Subject: STATINS AND CK
>
>
> We know that statins can cause a myopathy and elevated CK.The BNF advises
> that therapy should be discontinued if CK rises to > 10x normal.What do
> our
> viewers do?
>
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