It does sound as if this could be benign transient hyperphosphatasaemia of
infancy. We run ALP isoenzyme electrophoresis to support this diagnosis.
Electrophoresis on agarose gels shows increased mobility of all isoenzyme
bands due to increased sialic acid content of the attached carbohydrate.
This is easily seen if a normal patient is run as well.
Crofton PM. Clin Chem 1988:34/2;335-340
*************************
Bruce Campbell
Chemical Pathologist
Sullivan Nicolaides Pathology
ph 07 3377 8672
fax 07 3870 5989
*************************
On Monday, October 16, 2000 11:41 PM, Peter Stromberg
[SMTP:[log in to unmask]] wrote:
> A little bit of advice from listeners please.
>
> A 2 year old child takes his brothers nefedipine and tachrolimus ( renal
transplant ) and presents with the following biochemistry
> DATE ALK PHOS BILI ALT GGT
> 2/10 7565 3 20 4
> 10/10 2730 2.1 15 3
>
> Normal alk phos for growing child < 1000
> All other LFTs normal
>
> The child is normal clinically.The clinician wants to know the expected
outcome and should anything else be done.
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