Dear group members, I would like to bring to the following opening to
your attention:
ANNOUNCEMENT TITLE: Senior Scientist position in structural
biology/immunology with applications in T cell and NK cell receptor
recognition of MHC class I and class II complexes in Stockholm, Sweden
DEADLINE FOR APPLICATIONS: 10 April 2010
TYPE OF POSITION: Senior Scientist
INSTITUTION/DEPARTMENT: Center for Infectious Medicine (CIM), Department
of Medicine, F59 Karolinska University Hospital in Huddinge, Karolinska
Institutet
CONTACT PERSON: Adnane Achour, Department of Microbiology, Tumor and
Cell Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden. e-mail
address: [log in to unmask], Phone: +46-8-5248 6216, Fax: +46-8-30 42
76, website: http://www.ki.se/cim
DESCRIPTION/REQUIREMENTS: A senior scientist position is available for
an enthusiastic individual for a period of at least four years within
the laboratory of Assoc. Prof. Adnane Achour at the Center for
Infectious Medicine (CIM), Karolinska Institutet in Stockholm, Sweden.
The candidate should be a good team-player, with excellent knowledge of
X-ray crystallography and deep proven insights in TCR/MHC interaction.
She/he will co-supervise both PhD students and post-doctoral fellows in
the group and will be responsible for the expression, purification,
crystallization and structural analysis of proteins that are involved in
the structure of the T cell and NK cell synapse. The prime targets of
this project are T and NK cell receptors and a large array of MHC class
I and class II alleles as well as other co-receptors. Site directed
mutagenesis studies will be combined with a wide array of biochemical
and immunological assays, as well as imaging, in order to assess the
molecular mechanisms underlying the modulation of T cell activation in
cancer and infection-related projects. Determination of crystallization
conditions as well as the determination and interpretation of
three-dimensional structures of several of these proteins, alone and in
complex
, should be undertaken by the candidate in close collaboration with
other members of the research groups.
The Achour structural biology research group at CIM is well equipped for
all aspects of modern structural biology, with state-of-the-art
laboratories for molecular biology, recombinant expression in bacterial
and eukaryotic systems, biochemistry and X-ray crystallography.
Excellent synchrotron access is available at BESSY and ESRF. Applicants
must have a PhD, and experience in recombinant expression, protein
purification, crystallization and X-ray crystallography. Furthermore,
the applicants must have published record of previous work on TCR/MHC
interactions. Information on our previous work in this field can be
found by searching PubMed and via the CIM website (ki.se/cim).
APPLICATION PROCEDURE: The application should include a CV (including in
particular any experience relevant to the position announced) as well as
the names and contact details of 2 references. The applicants should
also submit a list of publications and submitted manuscripts.
Adnane Achour, Associate Professor
fax:+46-8-30 42 76 tel;work:+46-8-5248 6216
Center for Infectious Medicine;
Department of Medicine,
Karolinska University Hospital Huddinge
Karolinska Institute
141 86 Stockholm, Sweden
url: http://ki.se/cim
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