POST-DOCTORAL POSITION
DATE OF AVAILABILITY: starting as soon as possible, for 2 years.
TITLE: structural biology of complexes involved in tumor reversion.
POSITION: the position is opened in the department of Integrated Structural biology, IGBMC, located in Strasbourg-Illkirch (France) in the team of Jean Cavarelli (Structural biology of epigenetic targets).
JOB DESCRIPTION:
Our main scientific goal is to identify, characterize and analyze at the structural level, functional complexes involving selected protein targets to study the molecular switches and signals that induce biological activity. The aim of the proposed research project is to better understand the biology of a multi-functional protein which is strongly involved in the process of tumor reversion. The purpose of the structural study is to decipher at the molecular level the interactions between this protein and different biological partners. The structural work is part of a collaborative project involving three groups.
JOB REQUIREMENTS:
The applicant should hold a PhD in structural biology and must have a strong background in protein biochemistry (cloning, purification and biochemical/biophysical characterization). Experience in X-ray crystallography would be an advantage.
SCIENTIFIC ENVIRONMENT:
IGBMC is one of the leading European centers of biomedical research, devoted to the study of higher eukaryotic genomes and to the control of genetic expression as well as the analysis of the function of genes and proteins. The department of Integrated Structural Biology aims at understanding the mechanisms of cellular processes by correlating the structural and the functional properties of their macromolecular components. The post-doc will benefit from a technical environment including, the Structural Biology and Genomics Technology (SBGT) platform. The SBGT platform includes offers access to state of the art equipments for robotized cloning and expression tests, large scale prokaryotic and eukaryotic sample production and purification facilities, biophysical characterization, high-throughput crystallization screening, electron microscopy, X-ray and NMR facilities.
TO APPLY: please send a CV and the names of two referees to Pr. Jean Cavarelli: [log in to unmask]
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