Dear All,
We are looking for a highly motivated and ambitious individual to
progress our understanding of the mechanism of transcription by
influenza virus RNA-dependent RNA polymerase. The work is in the frame
of the ANR-funded FluTranscript project that brings together the
complementary expertise of the groups of Stephen Cusack (EMBL Grenoble,
project coordinator) and Nadia Naffakh (Institut Pasteur) in structural
biology and molecular virology, respectively. The project follows on
from a recent joint publication (Structural basis of an essential
interaction between influenza polymerase and Pol II CTD. Lukarska et al,
Nature 2017) and aims to reconstitute and determine the structure of
functional transcription complexes. A secondary goal is to use the
acquired structural information to develop new approaches to
anti-influenza drug development.
The Cusack group uses X-ray crystallography and cryo
electron-microscopy to study the structural biology of protein-RNA
complexes involved in RNA virus replication, innate immunity and
cellular RNA metabolism. Group website:
https://www.embl.fr/research/unit/cusack/index.html
The successful candidate should have a PhD in Molecular Biology or
related field and a strong background and interest in biochemistry and
structural biology.
We are looking for a creative and ambitious person with good
communication skills and keen to work on a challenging project.
Experience in insect cell expression systems, reconstitution of
protein-RNA complexes, X-ray crystallography or cryo-electron microscopy
would be particularly beneficial.
EMBL is one of the world’s leading research organizations in the
life sciences. The Headquarters Laboratory is located in Heidelberg,
with additional sites in Barcelona, Grenoble, Hamburg, Hinxton, and Rome.
EMBL Grenoble has excellent access to state-of-the-art structural
biology technologies with the in house EM facility being equipped with a
T12 microscope and 200kV Glacios/Falcon III . Additionally, we have
access to the Titan Krios at the adjacent ESRF as well as those in EMBL
Heidelberg. Other facilities on the Grenoble Campus include the ESRF
synchrotron X-ray beamlines, neutron scattering at the ILL, high-field
NMR at the IBS as well as high-throughput crystallization platform,
mammalian and insect cell facilities, biophysical platform and confocal
microscopy.
You can find out more about this vacancy at:
https://www.embl.fr/jobs/searchjobs/index.php?ref=GR00133
or by contacting Stephen Cusack: [log in to unmask]
Please apply online through www.embl.org/
Stephen Cusack
--
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Dr. Stephen Cusack, FRS
Head of Grenoble Outstation of the European Molecular Biology Laboratory (EMBL)
Group leader in structural biology of protein-RNA complexes and viral proteins
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Email: [log in to unmask]
Website: http://www.embl.fr
Tel: (33) 4 76 20 7238 Secretary (33) 4 76 20 7123
Fax: (33) 4 76 20 7199
Postal address: EMBL Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
Delivery address: EMBL Grenoble Outstation, Polygone Scientifique, 71 Avenue des Martyrs, 38000 Grenoble, France
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