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Dear SPMers, dear Karl, I tried to do a conjunction analysis at the second level as proposed in the email from 09/02/99. I took the estimates of the simple main effects to the second level, used 'multiple regression', but, unfortunately, the contrast manager did not allow me to enter contrasts testing for the significance of these main effects in the group, i.e. the effects of every single regressor (for example [1 0 0]). Only 'balanced' contrasts (for instance [1 -1 0]) were accepted. Did I make something wrong? Do you think that there is another way to perform conjunctions (AND masking*) at the second level, for example by use of condition-specific images as regressors? (*I would like to mask the interaction contrasts of two simple main effects [-1 1 1 -1] with the main effects itself [-1 1 0 0].) Thanks for any help, Oliver %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%