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The evening prior to the RSS/Biometric Society meeting on 
Analysis of Genetic Data the General Applications Section will be holding 
a related meeting which may be of interest to those planning to attend the one 
day meeting.

Mike Denham

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Details follow:

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RSS - GENERAL APPLICATIONS SECTION 

Monday 22 March, 4:00pm at the RSS (Tea 4:45pm)
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4:00pm PAK SHAM (Institute of Psychiatry)
Mapping QTL by linkage and association: models, power, and selection strategies

A variance-components model for QTL linkage and association analysis will be 
presented. Approximate expressions for the powers of the two tests will be 
derived. Procedures for optimal sample selection based on trait scores will be 
described.

5:15pm JOHN WHITTAKER (University of Reading)
Allelic association in complex diseases

There has been much recent interest in the possibility of using allelic 
association to locate the genes contributing to complex human diseases.  Data 
are often assumed to consist of genotypic information on family units comprising 
an affected individual and both parents of that individual.  We review briefly 
the key concepts involved in the analysis of such data, and point out some 
connections between the many methods of analysis that have been suggested. The 
reliability in finite samples of the asymptotic distributional results that are 
usually relied on will be assessed.  We will discuss the value of data on 
unaffected siblings of affected individuals, either in addition to the affected 
individual-parent trios described earlier, or in cases where parental 
information is unavailable. The possible advantages of enriching samples with 
families where one or more parents are also affected will be considered.




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