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Dear John, The original Cockcroft and Gaault formuala (Nepron 1976 Vol 16 31-41) as you can see has been around for a number of years, and it has been taekn as read that the final answer is in ml/min. This has been reevaluated many times (eg Smith et al, DICP Ann Pharmacother 1990 25 169-177) and as I have mentioned before it has been used in therapeutic drug monitoring for many years. Why use ml/min. One reason is that creatinine clearance gives us an idea of how some drugs are cleared and SI units or no, drug clearance is measured in ml/min or l/h. Graham Mould -- Dr Graham Mould Guildford Clinical Pharmacology Unit Royal Surrey County Hospital Guildford, Surrey, UK Tel 00 44 1483 (0) 406886 Fax 00 44 1483 (0) 455375 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%