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In message <0DA8CD9DC881D0118A0500805FC13E224850EE@BGHNT01>, Dr. Konrad
Chan <[log in to unmask]> writes
>We are getting new equipments (Vitros, Ortho-Clinical Diagnosis) which
>measures LDH activity in the pyruvate to lactate direction which is
>driven at 37C, therefore giving a completely different reportable and
>reference range from our present method which is driven in the L to P
>direction. This introduces a potential problem because MDs get "used to"
>a certain reference range and apart from using the test to detect "high"
>or "low" levels, they utilize the numeric results to correlate with
>clinical observations (eg LDH level and degree of hemolysis). 
Why measure it in the first place ?  We dropped it a long time ago and
nobody noticed.  Its very non-specific - we only retain it for drug
trials work - because the companies want it, not because it tells them
anything useful.

Trevor
-- 
Trevor Gray
Dept. of Clinical Chemistry,
Northern General Hospital,
Sheffield S5 7AU

0114 271 4309


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