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[Cover Image]<http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypyJt7DkePIa9FuVyTYs7uYxPrUk7VSYjXWZepfHOsIwQ-3D-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6JBSzwO4xLaWYDjTfb0j67zjo7c51UkJQjnFdypVJ2ljANprtTOlQTogFpSOKKt8FOeSw6djup1Mh0FGFDIej9qKFMKXWthYtHt71yjX8iYJSLNpowM0ZYMvtxNT9chHhefasStzhrOj-2FZ2wodZWSwD6kgu5F0-2BTad5lKbMNWzij7-2FKmVfSDS3pgJIekonKBqH2-2B-2BA249b88Qj-2BJvAnecu> Addiction Biology Volume 24, Issue 5<http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypyJt7DkePIa9FuVyTYs7uYxPrUk7VSYjXWZepfHOsIwQ-3D-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5jq6WfdfGBSkN2Toj1LLuuSVp5-2Fg082cyqhDwSLTMtnKJ-2B3eZb0xMAQ-2FRuYn0enfkq-2BElkced4yOWoqoWJuFLrYbBLMiJKrtqq3E7AiIevvvYLpKJkDXDa-2FU8l7K1tdYXHcFvofyyqCwWZWI78FL-2F-2FDnkwz3AlIWAbhLfyfAsSmOdk3xEV55uUluXEu6akSKJsCq4uBWLMbbgf9Ij1xnxl> Pages: 847-1118 September 2019 ________________________________ ISSUE INFORMATION <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhYAtsvtoxchHtbCAzDp9EY7aAXlWUXyqhCer-2FY3V9YTNz4ys14FZbUM7ouZcTx-2FBVNTDVm9vKGEY20vlFGmxfBkCFD15UvSWpHI1lZVvsCVo-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6hVGwVkiMq-2FX2-2FT0MnEvZYV8k7gw79jURJucVILGFBHTX6dHUfFsDXkVENDSyljsXB9Nx7TKH8ynFQAjuNuJCz8xPXokeWKOozB4nJbleXIs-2Bl0WVXp6co3PvTx7rJ9vLiRSkBos9qoxeQIENEKLLeYE2apmsX-2Bf6AO4M-2FHDiXfV7hMpAj4-2FfqJr3XmVl3ubh1AwU-2F-2BqeLeL1gvSwhyDRD> Issue Information Pages: 847-848 | First Published: 13 August 2019 PRECLINICAL STUDIES <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhtUieCzfHWYyACGcWR6NrWJjUivGGjip9keS0rBwapyhuZCZXPBn2mVsyNtDoWLQnYKisOynrlt7Iv-2BUFRe-2F-2B9onQS891cDzN0DhxMEx3Y9A-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6RXz9NTDfYnRyQrCkuIkGimwJkwr9PaN3PXLZns6kK2GyNgnqwlTqNUhm63ITbTLqSlrDC56EwS-2BdCyY5YuT-2B1GCpXAMwBxJJdoydsvHyDkkFgcHvx0JquNaiQEimFjnBWIguEQiVMZx7J4Mg6RKrlaDV9dMG2TXBuJyByO6lqW1ZotjRs1s51-2BB4ehNxdnPYuY-2Bh-2Bdv8YEuZrcr1KrwWq> Rats choose high doses of nicotine in order to compensate for changes in its price and availability Nathan M. Holmes, Jiajing Pan, Andrew Davis, Marios C. Panayi, Kelly J. Clemens Pages: 849-859 | First Published: 19 June 2018 [http://onlinelibrary.wiley.com/cms/attachment/4ef38595-c186-45c8-b2b3-e4fc29f32e24/adb12637-toc-0001.png]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZClxO8xXQVKMcrg-2FsVfRHCkzSpV3to1ry3-2Fokj9a9vzgdoEBUWn0AjjQ3MM5KvaiYWR9Gd8trhB6FwQdC38IPQw-3D-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ7ykE-2Fdn5EtPC0n4JG3flPes6-2FyWa1CWKJTL7-2Fm-2FMbqKnAyS3dugew-2FFr7JE0xUrd21sL5RLUxT5ZMRpKYI4e2anNiCvvszkmDB9mL1xmj0-2BT-2FcToWoLA8kWWFTALcA02SGI5MzHXANNrd7N5AoV24H8D9WoVvfmcFKPknH0Bja56iCctzu0wNhSXs32F6UiBUiq8FfK2Bc8VoII1I2LeeK> Rats are able to choose between different doses of nicotine according to their current blood nicotine concentrations. Rats compensate for restricted access to nicotine, by choosing higher doses. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhqaeSYQ0ggNC-2FdxKmZ5JbnwyD8ohpsregRIFSJiX87QEKowblecv72plf3OnmJasvZomGja33NgbvREm79pmG-2BANZWqDVHKWXHqiOLCqr60c-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4thEclBSSSOMgRm-2BTX64N6KKpb5fQ1TFzEdPkx9MAZ81WHtDB-2BuSgbe0PS3md014gn3hty5nBAsC68RLhpLwZ9CzxcB4FcG-2FxtUX8ycvu9e8RMLTTicXeLQxkphpRK4dmafGfDveOXZtqGWpRUZAhhSGvec0om1odxEcgscWqIOR2k4haByYvHDnKEeCSEKcJ4PqyeWFltKdXveo1u5IPY> Accumbens brain‐derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking Ana‐Clara Bobadilla, Constanza Garcia‐Keller, Victoria Chareunsouk, Jeffrey Hyde, Daniela Medina Camacho, Jasper A. Heinsbroek, Peter W. Kalivas Pages: 860-873 | First Published: 11 June 2018 [http://onlinelibrary.wiley.com/cms/attachment/a373dd89-505b-45c4-b583-282defd2b60b/adb12638-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZ7jx82YhaokxhcYEzzCboY55zr-2Fequ0rR4YocP38fpViQQJovDeRgOdRDDd3DvspwrMg5TV9UUq9cAJ3UQFbjv3WHea0H-2Fn5lNUR0LCoeXYQ-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ609ZJ6LM0wJNgsHjqrJFbaU7tXGjdz-2BY-2BulptGWXgCamU60dZWw9vTmyf3ILPTqvewxUzlOwHlP5t6WEFuDtM-2BMS5-2B-2FBcq0ApxS4224Xan338VKin0eCpWVxWrir4ln2O2u9lfQFK-2FCWRKbT6TPBGprbtYCzugNWHTPOdYNo-2BwkF82NRW2rtyHKmU5yY8HfbeAQ7nRXacMVbM5b0SfZqCc> We investigated the effect of endogenous brain‐derived neurotrophic factor (BDNF) secretion on cocaine seeking in the NAcore and discovered that BDNF‐induced tropomyosin receptor kinase B (TrkB) signaling during cued‐reinstatement promoted within session extinction and decreased cocaine seeking. We were able to pharmacologically recreate the inhibition of cocaine seeking by acutely microinfusing BDNF in the NAcore before cue‐induced reinstatement. This effect was specific to cocaine seeking and did not alter inactive lever pressing, spontaneous or cocaine‐induced locomotion, or sucrose seeking. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEh-2F764x4CvntUJU2yPmXlLYGia4NUjR6vpLBSI6MxIxT9tt0NuCmAWV1wfpXDh8c-2Bq9jiVdNEcVJZViBWPFro5ezYXVcPv-2FW7U3XxIsDn0Pr4-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5YUe1mKbG535CSA-2BS3wLjV6WyNNm7T0qhC4AS67Je97hbOuFy2Neny-2ByjdsUA3FK3-2BpeZWW3Xl4wJOSnfWmD0DkX1Lp2tdgBIJqCVYdj9JpWuDOQrst2Da4ZNnKy2cjwQhwnTKh4b4qMvjZ3jMHXWuIZsNGXKtwUpYrcrI2t5MnJqaUBZCOKNF3kMHAlw-2BmE8i6vYu3hbvMRuPbXJbCWc5> Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine Scott E. Hemby, Scot McIntosh, Francisco Leon, Stephen J. Cutler, Christopher R. McCurdy Pages: 874-885 | First Published: 27 June 2018 [http://onlinelibrary.wiley.com/cms/attachment/6c6437ff-ed76-475a-8e3c-83b11b4fe456/adb12639-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZ-2BGsqEkjv5Lzo4bMTz-2BB8fFj0NoD3KqDFncEVJ7sAb-2FrcKw87-2FMagD2Sg8CTsegikW2KMrpt0HFnfVERFF7ZiHyjxDDTrDDPIwJiSjEn64Sk-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5Up3N5oZZckFmjJkSDCKTv9UVXqx2erySXzxTx7SDEQscpKktggOlodPLFkRv4W4Sd2AFA2kUuHdY1rTAIvm3h-2FIOs8F68S8B9Yv23slq22V12gikob9k0-2FRANTdNlT187ZwXQA4-2B87y3qOMEt3FxRTy7PWGgA-2BnHte2bw43wmDxZsi-2FepJhUeQwg-2BWKbHhYiuUyLhM1mHTGkTwvD5ni6L> Kratom has received considerable attention due to the potential for abuse and the potential to reduce opiate intake. We investigated whether the kratom alkaloids, mitragynine (MG) and 7‐hydroxymitragynine (7‐HMG) would substitute for morphine and engender and maintain responding. We conclude that MG does not have abuse potential and reduces morphine intake, desired characteristics of candidate pharmacotherapies for opiate addiction and withdrawal, whereas 7‐HMG has a high abuse potential and may also increase the intake of other opiates. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhX2fpUGvzG-2FhrLnPvdDXN1TvjOLcLfvlWSWb-2B8Z4aFXjuWsQm-2BHaMpsVvn-2BAPBeeHKIk-2F-2FfRKQg2Lcw2ISMGTCWtX-2B4lNM9CJz-2B0EsRISjdE-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6mcq10fuF0zCORuNKsEiHrmuAagY9TDLpWVLegig15A0jgRW6s9vybPKi6BaVPG7KJkvSit8Z3xu3uN-2Bf06IFm8uHsZV7nC8GRGLl01tDAGNJbuBfEhIvoRg4twOMA-2FYarvjymitfTi-2Bt-2Fq-2Fb7uI-2BDeVvm9Hzi5LkQ6FAbZQGGBxEcGljy5YvAGvqKbuWLVh8LUhHUHS8RSoFUKTv4pyuc> GAL3 receptor knockout mice exhibit an alcohol‐preferring phenotype Shannyn G. Genders, Karlene J. Scheller, Emily J. Jaehne, Bradley J. Turner, Andrew J. Lawrence, Susanne M. Brunner, Barbara Kofler, Maarten van den Buuse, Elvan Djouma Pages: 886-897 | First Published: 09 July 2018 [http://onlinelibrary.wiley.com/cms/attachment/5b65206f-3397-4740-be87-e22bd52f3d35/adb12641-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZyuJwMIyU49G2cM3e2MJ63vOgqbWjSLMAitj8OKgc5ct1-2BTHxzl26Bq64HA4Je-2F9fyK0BrfKi1VTm3b5rwtHmrZLiyD7oOKOIdgX7H-2FcHgNA-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4PAfNgCocz5FPer4ctPBXMqKW4sKrAacBlpA1w2-2F3KUbg-2Bs78c8hxjEXx4mbD18fBCPL5aGoobiQKIDE7tjpKBp4PcxjTRwfgeSAAHLhdfyZ7ZRhUffuWsn5EvX-2BdLkQXEGNfbkVFjGLCaHO-2BuuvBESZXFqwRQnIMSYc1ZqcYO8mKSh0KfVumOjDBnp6G0qlsvUDUfu8ON5uLr45qFvuVR> Galanin receptor‐3 has been linked to alcohol use disorders as well as alcohol seeking in rodent models. Antagonism of this receptor via the selective antagonist, SNAP 37889, has previously been shown to reduce alcohol consumption in rodents. In the current study, we show that galanin receptor‐3 knockout mice have an increased preference for ethanol as observed by a two‐bottle free choice continuous access paradigm. A battery of behavioral tests revealed intact cognitive and locomotor function. [https://onlinelibrary.wiley.com/pb-assets/images/icon-lock_open.png] Open Access <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhTR-2Fkp4J1ThvpbofGlGZ0ALxup58EIhnx6-2FT1NcLl8U4gt1uE4r6Euu223Q5D-2FHUES1j25Gz5H5M9UjcTw0EAWMglUB-2BJHeGbnRkE56gnlBw-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5q8bdyE-2BMFyVf2nB0rnyUA5NSrko24pJ2d-2BFp00F-2FGFGUNEj98LcNpWGrZzKk05gQ45k0N9X9ocLj3-2By5k7G-2BF5QenrL27mdQ2UL685-2FwQ2bcXIAktuiWBUx4Nek8xmQV8l8UU7VGZYupi7wlnN8E-2FyJR-2FRibNZhnssc4p9sz59FEOYtX0mWqlDYe5ztL0CGmYwB1kw8-2F3-2BZPkwIUbCjA6> Social deficits following embryonic ethanol exposure arise in post‐larval zebrafish Yohaan Fernandes, Mindy Rampersad, Emma M. Jones, Johann K. Eberhart Pages: 898-907 | First Published: 04 September 2018 [http://onlinelibrary.wiley.com/cms/attachment/51a9f940-0621-4634-b2b0-da91d03dd04a/adb12649-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZHNQ2-2FmK-2BBDhhRLCmPO1ssnnoPxz5QeefvD0S4UTwuHHeF3VShAoPqyxFNP3ubJR-2BO32GVWb2ZhJ6ycY0O6jBLRZwnXE-2Fq2uqXDcQYo4gzIo-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5nNjtTRIlU-2F94rFSkgj9C0N5YYG3XbIK68HEM-2FrBOeTC5l3pzi5lNnLx0GoBZUyC2P6uucmGX9hknV6MNNtLBpPAlx3mz2-2BeWU-2F38oCzjFI3vQ5q-2Be-2BDmzLXcySAw5drYQf-2F7FjJ37D-2BhBSLOhpbg5hTbTU-2BrNAKol1ZWgSUoZbl-2BJ3-2FwM2hWNUg-2BImsjPscwqPzo2G4OFCvYjYip4uubG> Embryonic ethanol exposure does not effect the social responses of 3‐week‐old zebrafish (A). However, when the social behavior of these fish was reexamined at 16‐weeks ethanol induced behavioral deficits were present (B). <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEh00JbAP6QAl0leiwibzRFCwZxN3I4TtXX3YumttkBhcEaHyRtlbNKhb3Zv5oNfm5wpbGpIzQDWW89P4256sBmGVukqqs-2FqYYPg0h0g2an5iE-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ76bm0wk1w-2FWkLLtPwodLgnRvHKy-2B8q4hjm5sYVjLY4YIVLagsjkrA1EhP5TcronIkeNZzxWPlF8rRm-2B5MYzGohhMkeSuBKmY2bvlp-2BjJg4QIiZSqHIKdiOyuqzqhrWajdZc0yiHwYHPwMdNS-2BCn4-2BbKBP-2BFk7GeG-2FV9UOnaZmInuGA2-2Fr3KNUTzcg9LMpKHt1souIv-2F201UoYSrU8YFSl3> Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein‐2 drive reinstatement of alcohol reward seeking Sami Ben Hamida, Sophie Laguesse, Nadege Morisot, Jong‐Hyun Park, Khanhky Phuamluong, Anthony L. Berger, Ki Duk Park, Dorit Ron Pages: 908-920 | First Published: 18 July 2018 [http://onlinelibrary.wiley.com/cms/attachment/10aa16fa-c5bd-49d7-b748-fae06677f6f0/adb12653-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZ21KFt6Jj2jXaERdfSMo9zkeXjGthNevgt0wj69NzgBZ0n9aTbJIBebmRIgtZL5yphV8s2HhAYZtNj4LUaGlE53Ny1X1bhecW9-2BkSVb1BStM-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5pGNF-2FXDIXVV3QMLHB3WRjy2INYduhA3OkjrjWs6qRDkXnntMbB70I7C-2F3mj6-2FYooSoQkrpTQBjlsWXX-2FDP1P7Eo3hqTmRTzUsCHdT9mudwm28ZcxN-2BNOzqIrGu-2B6NLSnafb9SVHlaVQUO35xYWxVl4yAHviZBxW-2BAeeo89V4YJFR56s0zluNToC5sKaHlzahfcWw-2BrqbN38t0YfAmBEl9> Reinstatement of alcohol place preference activates mammalian target of rapamycin complex 1 (mTORC1) in the nucleus accumbens of mice, which in turn initiates the translation of the synaptic protein collapsin response mediator protein‐2 (CRMP‐2). Inhibition of mTORC1 or CRMP‐2 by using the Food and Drug Administration‐approved drugs rapamycin and lacosamide attenuates alcohol‐priming‐induced reinstatement of conditioned place preference. Our results reveal that mTORC1 and its downstream target CRMP‐2 contribute to mechanisms underlying reinstatement of alcohol reward seeking. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEheJjqiCaApkAI5X7L0uQA0DCnZAN6yTmr4MpqG6r5147McPTSZw-2BrUIfEyWTfcAED-2BgnDBfyFzp0jo214KJa5mkO4kv2NqPuyNINVoorEFKc-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4LFu4gY8AzLf1xDK-2B8hZ6dTqjTvFB6O0H89V2bwUZOZTUVhfsSshN6Y6Slqqg34a-2F4HS-2BOkNLEf7g-2Flpi7LXVcrCQ4Z-2F7wZTmLY83p1mRnVoMOrrQ8zpxPewR6Q4jvH8j9LNsPc4QWza-2FpouRjlPFiMugXpbYgoYCe6bbOmB802HFUYgZtbPBlYZ6ghU-2FUYfx2RpXl6df-2Bj8MOkzlVa3rN> Cannabidiol affects circadian clock core complex and its regulation in microglia cells Geneviève Lafaye MD, Christophe Desterke PhD, Laurent Marulaz MD, Amine Benyamina MD, PhD Pages: 921-934 | First Published: 11 October 2018 [http://onlinelibrary.wiley.com/cms/attachment/695363b4-7287-4a43-afb6-460b97fbfeab/adb12660-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZTfyvcA1oVjxiPqvURuaovhpJrSBa4iIGzrc0lrf89Ib9Jc3glGxcJYvZhaV7iT-2B1kBRe6M6LQIREjj92qXDW6jAfSgkItlYt0CfN-2Bvhdv6A-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5N8b5ivmdDeNT-2B4VkgJ9m-2Fuesp0D-2FTYDLtr5DiTORh6iTSg-2FBmks5phd3yZ5cIpI4vUymx0Lja-2BrBXD6bZoyBXG12a0ej9eA9EBdI768PfAE4QnyhRIbfagEt-2Bp4A7cyiWu3PvPM8BQ-2FmaJJA8-2B-2FUx-2B3-2Fg2Z3M6IaMXrOdQSm9P2xagnl6581m-2Bc8dE5tqpaRJLWvRWE8TFzg8XT3f5VOl> Disorders associated with cannabis use are often accompanied by sleep disturbances. Starting from the hypothesis that microglial cells could be implicated in addictions through acting on circadian rhythm, impact of CBD and THC on the expression of clock genes has been studied in microglial cells. This work highlighted that CBD but not THC regulates core clock genes in these cells, which is in accordance with international literature suggesting a CBD‐stimulating effect at low concentration. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEh-2FrPxB8Hz5R1doVusdnYV-2FGx9nfVuv70Pju9etPqesr8wl99H2rk5xyDZRw-2BtnFzg1Zt3ZOAzcPUWmyPz8bhX9AwoqYccS-2B9xsrHObblGnnA-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ789TWuwImxYgP9oOncxPAsIDpSXJVbJIKtY9-2Fb3-2F9-2BTuofOFIHI6DoymQAIOMMmq6ofzwV7EG-2Fuqcgh9npNZlK-2BqBKVbP4pXNO8CdyWqEu1HHFeJRzEfJtCMS5arcu94EKjKfuUuLxX-2F-2BDOwg2-2Bo0vHkFM35IsGnu-2B6bsthCYB8EcsthMmmWR3-2F6-2BUlgUg2fqoWG3d2ko-2FL8WaBPj5dNAz> Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies Siti R. Yusof, Mahathir Mohd Uzid, Eng‐Huat Teh, Nur Aziah Hanapi, Mazlin Mohideen, Ahmad Saifuddin Mohamad Arshad, Mohd Nizam Mordi, Irena Loryan, Margareta Hammarlund‐Udenaes Pages: 935-945 | First Published: 08 August 2018 [http://onlinelibrary.wiley.com/cms/attachment/81949b0e-6001-4e01-bcd3-e00b699d4463/adb12661-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZPJ5FgP-2Bawu1EZXEjhu-2F2eIOsvPv2G-2B-2BWo-2BJcBNvsEdKXSrGESvc5bXsUAF25PZJvS5TCt3nr0o9Y4bF-2F-2BU3NIiJcQ9-2FxRl3XHpL0xYiSUqA-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6z8no-2FGhK56fFe7qCNio9ApSuL2vsIMJd0mUchlF7H2Rrt0-2BCY47XQ0QmHrYjhBuFlIf2iHRYhReZTPS5VhHvc-2F6MLIJi-2Fn3MoewRA3bdPy7px7agudUZ9wZL-2BTfrFng0Qrb-2BwbrDqoyEoS7fJfiHjzS1-2F3e-2FfzLyQYt0pmGc1YvTr4xxCLLeUo9MqblIeGburnWj0h91lQYjsQ7ou8UM2> <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhzBkHKzQwWCq-2FjVhr3HIGZJQP-2BfkG3-2BYeCuZKNu-2BLQFwHIdUbXpkqj0RiNlxgb3wwOaQgLE-2FT752D0Z-2FQSp7sIpBXArcshBgnPH-2BVwFTGyzs-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ7ptejOsoTPpP1UD9QS2vQ3d0aciDBxn5bg7nfPHoblXy-2B228XEBj9vF0RxDS7stfOa4NfiWiTi-2B7eQ38vupQVXVs146vTK1T6Fvyrdeq83ztVa-2Behv4HuNXMRS-2FezyCvYH94IIB7P0EyKRCPlnmVJoIlE74kyEj0xPrdWtOmXHhoFP4FBXbdnHHWI0InZOc0ylUMLPLO3ZRINHClgLkxvR> The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice Mikyung Kim, Raly James Custodio, Chrislean Jun Botanas, June Bryan de la Peña, Leandro Val Sayson, Arvie Abiero, Zae Young Ryoo, Jae Hoon Cheong, Hee Jin Kim Pages: 946-957 | First Published: 09 August 2018 [http://onlinelibrary.wiley.com/cms/attachment/93d02cc0-3bed-4a50-b7ca-62016d817da5/adb12663-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZFsk8-2F4bcRTeSR4uvwNbFb01L6c9EIkVPzCpddDwSusF-2FZsTrqtAVksDSl30eolCUWqI-2FpkGebpBf95Oc5i7kUEIMDPGJlWDD4QEvReeW24A-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4h6h6Q-2Beofp5Cp8Gm1N1dIxSr5SZcJHSEa92LryyKiz-2F6JP-2BO3oZq62WIm-2BBmc1FfezIpGB9kPLH-2F1KMWJVjyH86cd2VR3tyFMiU-2BnZSV3f2zx6lS04Lxl-2FdozCdhbpOzWaFCiLQ15vradERsSAcfRhKH9Z7shOXoNCgkzKRr5WoJDuEIgY-2FwaHVhgmmE9hAMiB61vEwyg4Sn8q-2Fw8vNcc> Per2‐overexpressed mice showed decreased locomotor sensitization and rewarding effects of methamphetamine (METH) compared to wildtype mice, whereas the opposite was observed in Per2 knockout mice. Additionally, these transgenic mice exhibited altered expression levels of dopamine‐related genes after repeated METH administration. Taken together, Per2 expression levels may influence the addictive effects of METH through the dopaminergic system in the striatum of mice. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhZtFACfO516WBIKCkldcfkSEIHeQH-2BjkzhPaL8KStpZin-2BsgUNK82bZprVFBLVUsbuSpPs0AfDYXDPHkdzdG3eKwAKNqpo8C9bVKuWVSD7mc-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ47z1-2FPYq3nHosTOA54-2BK0Lqkiq5dkLfwi0U1J1YBLvAc-2BMkf3TkxA9MJ-2F1HhEpTTEiTtxS8SOFdeKEqbfRPKZ9eP0X6qVLsvUAw-2F-2Bp8LZ1wVorWDVoQ1k-2Bgdrj2-2BB32bN2Tkkb-2FIfO7LuCbvYO5nsX1Jn9YS5hY11g6C0glgf2y3XdeEWMo-2Bx7LZo7Nr9iTonMMp-2Fd6QRJl-2BT3m0vCh814> Social stress‐potentiated methamphetamine seeking Ashley M. Blouin, Swathi Pisupati, Colton G. Hoffer, Madalyn Hafenbreidel, Sarah E. Jamieson, Gavin Rumbaugh, Courtney A. Miller Pages: 958-968 | First Published: 14 August 2018 [http://onlinelibrary.wiley.com/cms/attachment/dcf1cbbe-40af-4815-85eb-44089fb0d7b7/adb12666-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZO8f3gUFR9A-2BolirqQS9jSdfR0yJ9TProFU0dcfPGBxDUpZCYkENpjI3UPo63Peev3EPz85Hp13XUyVYr1vj09DEO8DhlaeU98X7ub-2BoZsR8-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5cFeVRFl0OOC5rDrY-2BmRLZKKWPU20TET6z2UewvGcOMMdqHT99-2FpPkwKKWHx3sAaC26CuLK44x8OmnJV4vzj-2B8GliPHQlCsADqwqfvDV37HCygU9UkimHw9O6Ca1Sy1i6827GmMUyfNutPf-2BEo8nO6v8RZ2IS-2Bpo4thv7xSOJEzvCMiBok2a4r1y60Kadr5T2GNnsMIAVFvj23m4-2BE7ogg> Social stress and drug availability are directly linked to relapse in patients with substance use disorder. We developed a rat model of social stress‐potentiated methamphetamine (METH) seeking where rats experiencing both a social stressor and low dose METH prior to reinstatement lever press at a higher rate than rats exposed to social stress or METH alone. We link the basolateral amygdala to this effect and present this model as a tool for further mechanistic dissection and therapeutic discovery. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhjvNN2lUS6T2ijFlMe8nGvd7FAS-2B-2BBrxBnMXjcasggKmrEsBzxq2lHO9ZpQH5wmvtqw9PGAvi2nvd17jwDKzNcydLIaCXATuaG0W-2FmwVn9wo-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6jgIvA4IpabAVrsF0Jy7-2F6Z2FjLjIJNfNFgNJ090KGwmGWhRKUYlQaWhVQrerlzY3ZOn1D3mOr8rhAXpVMKzct7AuYqysfzoTwpbCv7N-2BnruiokjdmUtdtORrcPhe3ntadtIP1FGabkoGxiQKVetBjNrV3S1jc-2F7IIl48igjE1uny3hRha-2FjiTlZdFOPnSqQ5Ur84f7N6qmcH8K-2F-2FxQxB4> Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence Irantzu Rico‐Barrio, Sara Peñasco, Nagore Puente, Almudena Ramos, Christine J. Fontaine, Leire Reguero, Maria Elvira Giordano, Ianire Buceta, Itziar Terradillos, Leire Lekunberri, Juan Mendizabal‐Zubiaga, Fernando Rodríguez de Fonseca, Inmaculada Gerrikagoitia, Izaskun Elezgarai, Pedro Grandes Pages: 969-980 | First Published: 14 August 2018 [http://onlinelibrary.wiley.com/cms/attachment/18412b3d-dc3c-4595-8245-55bf76b4e499/adb12667-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZCoAcW4UlB4VjLIIcCNnXLElejSHSg1GOD4y-2BpDrIbyP2T1XlfqqV7VngCAW9Ed9G-2BcaehnSli-2B8MIGDP0CrCfN6w4FVrd-2BMLziBfCCVTPeg-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5QaLDym3zHEhIwYnZDfzyAGFhtGADU6aS3VoKKqM1553jOEzpCH-2BHWkRxBIrOVroLTMz0GYQ4G7EsZ11TMSTuku2My-2B2FwqNJrJtpdDVqGjM547Rsm5SpBXHO-2FHutduNSb3t5EUQYF77NLJhPMI87V8Ee78t2uPVKU8O2TuuO8LQPv8mkct3K0Vdi0cOWw1H3DIbEmPof-2F0GvUJcahR1ea> Young adult mice exposed to enriched environment (EE) significantly recover recognition memory (novel object recognition test‐NORT), spatial memory (novel object location test‐NOLT), coordination skills (rotarod) and balance (beam walking test) impaired after adolescent ethanol (EtOH) intake. The results indicate that EE exerts positive effects on the long‐term cognitive and motor deficits as a result of EtOH consumption during adolescence. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEh70fuomwcC5UkKKA3awbhNTXgZLM4IzWi-2B8qeadSdcF8g3K2r2PMiw5KlZR7vduDXJYWOv29REjxoa5HLHyRVDOYc5yNHqzgWUMHKZVeov78-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4QIUlyld3fmB0sD9siHFQUEUEfQQ2KWAg1WGiuxMZMmOYQ3IB4e5LlJgK115-2FHPlkwFSBDTsnYKY2QviU8s-2FtlyBoPrjIDxP2kuvggTBbjFCc3otRRJNnAsVcq79kmiypghNFFoC-2Ba3QY447M47vbLV31q2b5oKcy6jRBDyRRNlVNoWhv-2Brdp-2B7-2BXMzbxPJQgkEl3-2Fur4cyABuIVT5m-2BOW> phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats A. Bifone, A. Gozzi, A. Cippitelli, A. Matzeu, E. Domi, H. Li, G. Scuppa, N. Cannella, M. Ubaldi, F. Weiss, R. Ciccocioppo Pages: 981-993 | First Published: 17 October 2018 [http://onlinelibrary.wiley.com/cms/attachment/a0b40ecc-e5f7-4e5c-901e-8cebc42b0524/adb12671-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZKzhmIt5ML-2F8na7-2F-2Bmv7Gi0F-2FiTeR0G9o8d9LgKtxToyIA0acC3wF1cQZpj04giDYNqM1iufYKx4CFgKzWyhj7895q9yZGb6nrHNVGz1tp44-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ54StDUFd0nv067Z3Sy-2BBIu5I8BBGb4ac1ucoK67dIyqWwWBsK9zweJwpnleuvHeG-2BC-2FrEeaa1sSGssbF3f67DyxPcq87LmDvLfWOOwmgSPPl-2Fjcak9mm528lrrt2Py-2BzABuOjd0sVq6BSfuzA12jnQfe60lrK7mDjKBF8bgn3zL6-2FoOu82z-2B-2BTCrZk2M8q4UNtD50Jx-2BPVu76hPqmO-2FG8Q> * Compared to control Wistar, alcohol Preferring msP rats showed stronger functional response to amphetamine in the extended amygdala and increased DA release in nucleus accumbens. * msP rats showed higher escalation of long‐access cocaine intake compared to Wistar. * These findings suggest that neurobiological mechanisms that confer vulnerability to excessive alcohol drinking also facilitate the transition to psichostimulant abuse. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhhF9BWlg9PARbI1CM2mGraldraq0zHpr03MQNuiXm4psJOx7koVObgjdDq3C7ezKNSDY11hLXxZU9XCM87HoVdc-2FTu3LQNaR3OwmpJDonDhc-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6CDhWeQ6YlotKW0pU3AA6qzKghMIh8jI5xFTm6w8IRUsbt81I4PGKDwzmUUxJ6BzMrGYNRPW2r3Cr9kELYJD5XoOp0hujI4I8r-2FinqPIOJLBYnxetznHCysoi-2FGtNQE8ktryeG9DxKRrzrj-2BsH0p4VAps368fVXoENdxzR78SzN56FYDUJOu56gXKb5UmaTuyLRYJuxXmj1AeHIk-2BYVL0v> Intranasal delivery of mesenchymal stem cell‐derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post‐deprivation relapse drinking. Fernando Ezquer, María Elena Quintanilla, Paola Morales, Daniela Santapau, Marcelo Ezquer, Marcelo J. Kogan, Edison Salas‐Huenuleo, Mario Herrera‐Marschitz, Yedy Israel Pages: 994-1007 | First Published: 21 September 2018 [http://onlinelibrary.wiley.com/cms/attachment/d075718a-903f-425a-b499-a55804cdf305/adb12675-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZVi6PBAUhbLzFI2Irupx-2BK0QF44NdUPeGiYrKL-2Fe8qWdXVelvm-2Bv1lmuR0xBh695c-2B2NoluZAMylTSmVhQJ7ph-2B7FhkFe0cCZVsBSfysHUp0-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4JfhAkjEiWkhrmgGXqPkwuonUA-2Fvgni0knRxKqVi8MhThrqEOQWpa5-2FP1PIhJGiF1o1zwt0s51zF-2B-2FuC4zu5fG0ZwJHqxsxMuum3R4M0Mk4CGVwp5aNhFQom8aJcOWIOqlpdMtyTGnbiVVOQcuWYE-2FJlU3VtmQ16xcbvFMT17ZIIWTlJyQJHYd5A0yRNbjblmy-2F-2FJt-2FvYWe8iSgEtTOhVr> Intranasal noninvasive administration of human mesenchymal stem cell exosomes markedly inhibits (80–85 percent) chronic ethanol intake by alcohol‐preferring rats and fully reversed ethanol‐induced oxidative stress and neuroinflammation. Exosomes also inhibited (50–60 percent) relapse binge‐drinking following chronic ethanol intake, deprivation and ethanol reaccess. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhqQcJ8vfZPBUq-2B2cXebRHm5Wsg-2B9AAjvY08hUPopvGLTQYl-2BSYu-2BE8K4EiXUKRS8sqdMVFzhWx4pzunW02qP9knIK-2BkP-2F3FIufGXJKzZT6Bo-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4DKw-2B5nGBETTXgFELqURiFV-2BAw82HYuxdQ6YMHdatbcjzl-2FwunKozTg-2FeDmujX9Lx3edxodqZWHuky8B-2BGhk3Zg1T6DniB-2BkxStDKxCrZ2FcSRcBECMJ3GXGvsEJhEtRjmWVNI3IZDAko4ZaAauKBJi-2BBXgXsNgJKAR52Z-2FCUAHlbD7QVTZeG9S2Zqj-2FJWC-2B6v1AAk57x-2F35CMF6bqocVp> Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain Ainhoa Bilbao, Sarah Leixner, Shoupeng Wei, Lídia Cantacorps, Olga Valverde, Rainer Spanagel Pages: 1008-1018 | First Published: 25 June 2019 [http://onlinelibrary.wiley.com/cms/attachment/88c4c835-0e2e-4fbb-b17d-0fdc58c9c6bb/adb12784-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZ103QbnpBXs1HY6kwSI9NI8fp-2BNfjJ-2FKWBgNmCO7t0E-2F-2FiKmv-2BGkqxJhFClYnHgqG4VfeJIbmkls-2FIIP8cYzBdaNk3Otu-2BOk9ZJnsrbTjuKU-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5gxUCGFSo3yBsfqLMVOBdJrW8Qp5hk8sLnMjm-2FGBCdRaQNfxdIjuOcwYYNnXWgx1ZLxCCrQxP89YDDPKZBFd7SacKyeSPqVKEihYevAfUJ8ofYYIAmjUf0WwF2G7FTWCdMRkZ8vAkBU6aar3WP4qttK4yPLjfxULL2hsbGFp2mJZUzRSFO3nwQGnNcCVrJbc1CYCO6s8e3H2lGZZ-2B2iyNZ> In a longitudinal study using the SNI model of neuropathic pain in mice, we show the co‐occurrence of chronic pain and several alcohol‐related behaviors and phenomena. This work sheds light onto the variables determining sex‐dependent co‐occurrence of chronic pain and alcohol use and proposes that a lower sensitivity to the intoxicating effects of alcohol together with the ability of alcohol to reduce the negative affective component of pain may explain the higher co‐occurrence of AUD in male chronic pain patients. TRANSLATIONAL STUDY <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhJGSmEYKQLS11vupAPF24it31G3gMCaR1zLCNfMFztFo4vmTxPqBKBTAhYE9PFllOuyWtJNdR6ZZ4jXZKAOARK4iD0RglCOhjhVqUsgoAaMg-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4xGvZYpcPhd3UPWHN-2F31lgaGlltYgZxRNbOdjsC4YfX5O1ma644-2FvGquE60xyp5yxFMLJ7Fc-2F40dMfV1MFImEwQrUqx-2FWNNdkNXdfLJtCslKxUxOt7KbzMHZmXoqiThM4xsBEbTDM2OaxkFACgLYR-2BiImqH0jroo56B4VX5wAzi7BfoSXN48gkBVEC9qbr0qqnaESzBi3va5t5f4Bti6FX> Alcohol‐induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats Daniel Silva‐Peña, Nuria García‐Marchena, Francisco Alén, Pedro Araos, Patricia Rivera, Antonio Vargas, María Inmaculada García‐Fernández, Ana Isabel Martín‐Velasco, María Ángeles Villanúa, Estela Castilla‐Ortega, Luis Santín, Francisco Javier Pavón, Antonia Serrano, Gabriel Rubio, Fernando Rodríguez de Fonseca, Juan Suárez Pages: 1019-1033 | First Published: 12 September 2018 [http://onlinelibrary.wiley.com/cms/attachment/376c9b8e-8817-4649-9688-6604730b4bea/adb12668-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZKsCmArBBioI3kl1t7dzhtSI8q7GtrjHokdIj3Ui5DFzH3vzBe2tealfeY9wYe6nGg77UEMx0GowlUrnQ71EAeXUOb-2F4DfOLXtNMtfywLIrg-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ6SUeG1Vdh7DllAx5UFuIPqUS7C-2BI5ykCmHdfrSl4z4sm3q2OiWhw8Xo6i5Z8tRZ0fjBUbM367u18FeZhMN63DuyudDU2GrYz8l4BgrkKYifXTHEXTzIOgwAGCA9g1Vo4ZUFebiUpc1UXHggId7a1znFEk0Nwar3kc1P7bsbVp2yN4PYIwy-2BvonLcnHm5NsTzvfhOUqFDNl4XilWZupUgD8> There was a negative correlation between plasma BDNF and cognition deficit in alcohol patients. Hippocampal Bdnf levels and recognition memory negatively correlated in alcohol‐exposed rats during adolescence, an effect that was associated with a neurogenic regulator ERK2 deactivation. Early alcohol‐induced cognitive decline is related to BDNF signaling deficits. CLINICAL STUDIES <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEh-2FJhDCe8st4kZvnuEfxvPXvXVRHk3Kxb8eG3guk3Rvwxz-2FvhJY4uQKewEnVOApMrxznPfapBq39VG-2BOxWQWzIFXZkQc4a6atptO48BD-2FGCcA-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ7OxVesMzeN6OZLOKwSXHzG-2F-2BYxYDLSgR3oeMYaajwzvHqdHuL07CQojKIs6UBr-2BjGr-2BJ2o-2B9otVGJsLq34Ai657qTKpYqumLOYWiHmHV256WEQNqBJ-2BCjjZ69ooXcCEbF1de3KpxRA3A2zaOfbtqt0Ihc9Teg5NhEtAljFstE9py1g1YRP9O0O15lDAxtUvRZLW8QLNWnaWxGDPGIrL9RE> A bidirectional path analysis model of smoking cessation self‐efficacy and concurrent smoking status: impact on abstinence outcomes Matthew Clyde, Andrew Pipe, Robert Reid, Charl Els, Heather Tulloch Pages: 1034-1043 | First Published: 08 August 2018 [http://onlinelibrary.wiley.com/cms/attachment/38774b0a-f1ad-43d4-85b9-61f9391cea79/adb12647-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZYS-2Fl5mC1VrrsbYQOyS-2FPXxFxc80LpUpB-2BhooLPVlMgasfQt2a-2FYGYTCUkwuS1Uwr8NdW6QlVIpJNDbVBrCWix34U0UweUtYOKexG5tsny4A-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ699zh-2F-2BvmHFJ257Qj9ASSX8-2FgX04coUrGqUHpWhkqClwAOxWp1xRmkr1BV-2BNyaUx7D-2FatBlIoOvk-2FPe5QG2BkIAv97tJnH4U2GGbpOrHySDV3u4BXNPjd73xVdd1ynq-2FCZEBGTxACv1vtjDrSkHZzkxklY0evr5U9FtRDEcR3cSCBNT4ubbQgVQkchWQyLL1GGGwxL9d-2BkrGcNRmlqCBP5> Self‐efficacy is a strong predictor of outcomes in the addictions literature but has been questioned as either being a cause or reflection of behaviour change. Using path analyses, we demonstrate a bidirectional and reciprocal relationship between smoking cessation self‐efficacy and smoking behaviour during the treatment phase of a randomized control trial. Changes for both self‐efficacy and smoking affected subsequent scores, with scores on both measures associated with cessation outcomes at week 10. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhEl2ywiLI17XjGmpajUVJ1EsS9-2FxlATs6Z5BqhQiK2YKApH3xr9UDxVJMagyXRjsKKboeTKJDjVn4bqmvoSyHeorkMY9HDLDrkRcDaX6-2BDsY-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ43rts0Zd2UsOAdV59Zg1dY-2FVyoS2fy4h6pOThyq-2FjDao6x2RlogKKj8tRpt0CvP5pjWPDaARFUfUGCQvtX6uRaAVZfCcLZpv5lzDqg7xfWIKkJ38N-2BFyW-2BRVGnODNuXMHwedCZdlpZkHVnzytKShNDfh6qWOnL1rqKfHwaC56DeFrFajmDeSvRGRRksVqpl-2FLQjPOOrMUN6aIV0LV2Q-2Bk8> Social motivational processing and interpersonal function in aging cocaine smokers Gillinder Bedi, Xuejun Hao, Nicholas T. Van Dam, Ziva D. Cooper, Eric Rubin, Nehal P. Vadhan, Leslie Marino, Margaret Haney Pages: 1044-1055 | First Published: 17 October 2018 [http://onlinelibrary.wiley.com/cms/attachment/5e27e0a2-7755-4311-8214-1d42d751d453/adb12669-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZQEQjyYFb8h0kUZm8NJ87xvbviXuEvivpYsfa1Mm9bFuOe7lcW9tVrUzmx-2F-2BA6JJdW1nGCavC64PhKnKCvZIDTppqb94rhn6SIq4bS9Hryco-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4xMDuZ5VkHU26rqgGAUO8qSuQ9MyzrV7oC0ZHQNSd1xNJpSMtJZOVZGDAfwhqJFXurrTYb-2B1f6svMq-2FmzaxGkv0Tnf-2B90tlEWxQG5xizIQon4BQumO-2BJ5y75-2FE3-2FJzHCtZsK1GC9O9EYtfD43d6kxIYIYvgB5PjUJ35pY4yuK9N8Kn4SOTVqxwLedDA6BhgLeJdVXBjrAWo0niR7Td4KLG> Aging (50–60 years old) regular cocaine smokers had pronounced problems in daily social function relative to demographically matched controls, assessed by both their own and their peers' reports. They had stronger amygdala responses to social threat versus control stimuli, with no other differences in social processing or cognition. Aging cocaine users appear to have marked, generalized difficulties in ‘real‐world’ interpersonal function but largely intact social processing on laboratory‐based measures when compared with appropriately matched controls and tested under well‐controlled conditions. <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhqVlTJlZ-2BE4D1yBDSo9MCyMUhr4cLjagZLxV-2ByGR3qNIqzDFVecJ2UAxIAoS9m-2BH-2FnCmbT30dl0K05YVSu6WnIyxg-2BK9-2BKdVrLj4XDXheHIc-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ5eaHEA3LOHIUS6rlMq3bTRDNlSES-2BcunG3U3bnv8cAkR02nwjAc75vq1vCX3kvWkHUxz9vW0hvXJgNVFjVkM2NM9wwc9RugGeKFd5bySq2v5uEa-2FbJk4G7-2Bc-2FoznU4-2B-2FmSXU12kXDlaqPllJUQsudAUv-2FdY70RQYMJFBYPj5fQL-2FdcxMyJt4aQXBYwey-2BNvZ2m7v8sQqpphfuFX-2FyRFR4n> Using DNA methylation to validate an electronic medical record phenotype for smoking Kathleen A. McGinnis, Amy C. Justice, Janet P. Tate, Henry R. Kranzler, Hilary A. Tindle, William C. Becker, John Concato, Joel Gelernter, Boyang Li, Xinyu Zhang, Hongyu Zhao, Kristina Crothers, Ke Xu, For the VACS Project Group Pages: 1056-1065 | First Published: 04 October 2018 [http://onlinelibrary.wiley.com/cms/attachment/2100d40c-5d0a-4a4d-abc9-84d6dad79994/adb12670-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZS-2B5lTYTUiUcOyde6dAQkLRA-2FDgVZZcPLZuYwauLc7GzGAQJ4ZwytjME3npxpwVm1uhZzjzcwvSPZTK93AfwiL7Ye5LxebvJvj0FHXkxSFjI-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4RBY9UPThUwPq79Z3c-2BTQ-2Fz2g3-2BQAYwapBCW3GsoGRNg-2BffgS5eDhfMkgvTpeBGI-2FknYZYwV6tH-2FrE8CUOkukiYC3LHB8A5t0Wvgck-2FX5ffi1oojXCj-2BRfHcls0S7HQVEqZC7OmK2W1h1IaDgGjYbtLP4MOxnYsc0pZRhoOlGVzPEGvH1EKZ-2Bu4W3hrDdROtXNo3uRcHa6KOoqPCz-2Fx7XH> Using established DNA methylation sites, cg05575921 and cg03636183, from blood samples as a criterion standard for smoking behavior, we compared three candidate electronic medical record (EMR) smoking metrics based on longitudinal EMR text notes: most recent, modal, and trajectories using data from the Veterans Aging Cohort Study Biomarker Cohort (VACS‐BC). Among 728 individuals in the VACS‐BC, both DNA methylation sites were associated with all three EMR summary metrics, and the strongest association with both methylation sites was observed for trajectories. HUMAN NEUROIMAGING STUDIES <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypDYLmOREZ49UvzGxcwdvdbwYHbRuWVOUTqOGAjrAH2T29g0Lh-2B26gQjTzfXrdJ8Ggy6Hv-2BTveLJA8qkftyFZI5iNcwknHhm8-2BkPkT2cgjMgj3R4e8BwWGuh2GZW6ugTOWIqEtby3UdDi6bpa-2FWOfzxBxCGBENDkf5tJFXSMQ5IHsFjLKJZLhjFAyAVu2Zv-2FX3Lt8NmKwHBV1QpKc5HhK6y2ELxN-2FgconZcIqkz4LdBLjJs1SF1kGUQ1TUnPPCfSeWZL1kKPEeEly7JoCkA-2FOEhZkF5U1kA90VHTEKISGJRJkys-2BqGHL8rWsNgl-2FAzFPPPzQ9BLjhfNoW4eVr2ml2HHTNwUKPTeEO8Zwvq4FT7q8BVV67wrvig8HqK4BtmcXdw-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ504d3V-2Fa-2FQ6l4unKn2z1N2xsTWwCoZeN56vvlTLeUJXWJuZMhnsPOC8Elu9o-2B-2BkZ6IEwm72Qi0UDXdRcCcJhQrupWrF-2B0LvPjPhD0CNuJxNJH9Wx2ZoWtQWz5dr1-2FfxFQ35Mvn-2BCipFI6Lv4F-2Bv8CJi98HO4FN8MPBYB831oQY6aKgKEwmmjJWhcrLvEWftHAEZHF95Q-2Bl8HToEKWWC0fd> Ghrelin modulates mesolimbic reactivity to alcohol cues in alcohol‐addicted subjects: a functional imaging study Anne Koopmann, Patrick Bach, Rilana Schuster, Jan Malte Bumb, Sabine Vollstädt‐Klein, Iris Reinhard, Marcella Rietschel, Stephanie H. Witt, Klaus Wiedemann, Falk Kiefer Pages: 1066-1076 | First Published: 09 July 2018 [http://onlinelibrary.wiley.com/cms/attachment/1058a498-a5bc-420a-83fb-2b72634203a6/adb12651-toc-0001-m.jpg]<http://el.wiley.com/wf/click?upn=Rbpr-2FJY-2BNxzbBWSizSW2gSYTZpQA-2FzHfb4Brt5RBxTGz4zUuyXuhbtDTdb-2FsE2XZElLD9bNWaH5kac1aXjtrAnUeus6-2F8UaJfNkFg-2BB4n-2B9RtZ-2FLY3IKHerTQBbMzZQJhGMSFnrV28cD5vibu6OoD-2FzjdREcjneC94CyjWP9eQg-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ4zrVDIvPwHzsHHlY9rnpGQlYAxRBNc-2F-2BXek5NU0OFHTCAgE2Ow-2BD0X7X5dIl27wqC20Y-2BVyuFopUK7u3iAY5qPrXKqpWgvEusjxQ2bg0spXHs-2FFToWG7g1v4kS-2Fj-2BfN1Y15cTbyc8Sb4IooG2MoYch1jcRI5HNeLzBrgLKrBuvqjh-2FeIqDYLy-2FKWF5sf02evMrh2sahghEq7AT27RHLeFp> Ghrelin has been shown to be involved in the pathophysiology of alcohol dependence, affecting alcohol self‐administration and craving. Alcohol‐induced brain response in a network of brain clusters, including the right and left ventral striata, showed a significant positive association with acylated ghrelin plasma concentration, which was significantly associated with craving. Mediation analyses showed that the association between acylated ghrelin plasma concentration and alcohol craving is mediated by a cue‐induced brain response in the ventral striatum. 20 of 24 articles shown View all articles <http://el.wiley.com/wf/click?upn=-2F4d0Y8aR13lVHu481anTzUsxpIxqnXKO7aDEMGBvYypyJt7DkePIa9FuVyTYs7uYxPrUk7VSYjXWZepfHOsIwQ-3D-3D_lLhfgJBOrQRSOXGSy-2BPPeHvJAzXqQMwiN8f7LYJVoIG-2B0lcxqJzHj6wR8RMN8cEn4DH4-2B6LguSC3PADapMWQtKApHFxdCOQzKVZJMB5ZkZ565boOrjqutop2CvG9QIZEYl66AKG1UlHHSZVaxUl3sZwcAlZ8eVvJyTyJvx96021wvUhbq3LJ50pOMgvA3MAV4qmbtu619yjubbv04YMffbHZwMxPH-2FFPuX5j6OtnHoDWGQCGMZXjRqYOPGjNtmeSmJ0FbAZE9foMSxxuh-2FWBVE34q6e5CKb7l1uLyHdMQV7oCagVZxmSM7juegp5VXKW> -- The University achieved an overall 5 stars in the QS World University Rankings 2018 The University of Stirling is a charity registered in Scotland, number SC 011159. ######################################################################## To unsubscribe from the THERAPEUTIC-COMMUNITIES list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=THERAPEUTIC-COMMUNITIES&A=1