I have a question regarding a 2x2 model (gender x diagnostic group) I am running in SPM. There are 4 groups. The male groups have 2x as many participants as the female groups (i.e., 140 versus 70). Is there a way to account for this difference in SPM, perhaps by weighing the contrasts???


Thanks in advance,




Rachel A. Rabin, PhD

Postdoctoral Fellow

Icahn School of Medicine at Mount Sinai

Friedman Brain Institute

Department of Psychiatry

Neuropsychoimaging of Addiction and Related Conditions (NARC)

1470 Madison Avenue, 10th Floor 120