Dear FSL experts, I have some questions about the path distribution correction option in probtrackx2. I checked the help manual and found that --pd option is used to do the path distribution correction. After running the script with --pd, I found that new-created fdt_network_matrix and waytotal had no difference with the results produced by the scripts without --pd option. Since my goal was the distribution corrected probabilistic tractography, the results were still the same after adding --pd option because my calculation of probabilistic tractography only depends on fdt_network_matrix and waytotal. In addition, I noticed that there was a change of the fdt_paths.nii.gz file, which means there was a difference between results produced by two scripts. Would it be possible to explain why I got those results and how path distribution correction actually works? I also attached the script I used at the end of the message. Thank you very much. Sincerely, Yingtian /usr/local/fsl/bin/probtrackx2 \ --network -x ${save_path}/targets_Power.txt \ -l -c 0.2 -S 2000 \ --steplength=0.5 -P 5000 \ --pd \ --xfm=${pathproc}/${subject}/data_${method}.bedpostX/xfms/standard2diff.mat \ --forcedir --opd -s ${bpx_path}/merged \ -m ${bpx_path}/nodif_brain_mask \ --dir=${save_path} \ --avoid=/cbis/projects/brain/R01DPS/analysis/templates/CSF.nii \ --omatrix1 ######################################################################## To unsubscribe from the FSL list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1