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Hello, If you calculate your transforms with original high-res structural, you can then apply them using a downsampled ( to DWI resolution ) version of the structural image as the reference. Kind Regards Matthew -------------------------------- Dr Matthew Webster FMRIB Centre John Radcliffe Hospital University of Oxford On 30 Jul 2018, at 13:15, Samuel Holly <[log in to unmask]<mailto:[log in to unmask]>> wrote: Dear FSL users, I would like to ask if there is a way to register my distortion and eddy current corrected DWI data to a structural T1 while keeping the original resolution of the DWI data. I would like to avoid resampling the DWI to a finer resolution, as subsequently I will be processing my data in a MATLAB-based program which is very memory intensive. Thank you for any suggestions. Best regards Samuel ######################################################################## To unsubscribe from the FSL list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1 ######################################################################## To unsubscribe from the FSL list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=FSL&A=1