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--_005_6456B5B4883147A1A99B4A8629995D07kudk_--
========================================================================Date:         Tue, 14 Aug 2018 20:18:58 +0200
Reply-To:     Leonid Sazanov <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Leonid Sazanov <[log in to unmask]>
Subject:      Re: multibody analysis
Comments: To: Takanori Nakane <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain; charset="iso-2022-jp"; format=flowed; delsp=yes
Content-Transfer-Encoding: 7bit
Message-ID:  <[log in to unmask]>

Hi, yes, the command from "note.txt" works well.

Thanks a lot!

Prof. Leonid Sazanov
IST Austria
Am Campus 1
A-3400 Klosterneuburg
Austria

Phone: +43 2243 9000 3026
E-mail: [log in to unmask]

On 13/08/18 13:24, Takanori Nakane wrote:
> Hi,
>
> OK, the log indicates that multibody refinement itself has finished
> successfully.
> What happens if you run relion_flex_analyse from the command line?
> The command is in the note.txt and should look like:
>
> `which relion_flex_analyse` --PCA_orient  --model
> MultiBody/job092/run_model.star --data MultiBody/job092/run_data.star
> --bodies bodies.star --o MultiBody/job092/analyse --do_maps  --k 5
>
>> Also, a combined map of two bodies together is not produced - should it
>> be?, or it needs to made separately, e.g. in Chimera?
> This is intended. There is no combined map.
>
> Best regards,
>
> Takanori Nakane
>
>> Dear Takanori,
>>
>> This is the end of "run.out" file:
>>
>>   ?Auto-refine: Refinement has converged, stopping now...
>>   ?Auto-refine: + Final reconstruction from all particles is saved as:
>> MultiBody/job1110/run_ct15_class001.mrc
>>   ?Auto-refine: + Final model parameters are stored in:
>> MultiBody/job1110/run_ct15_model.star
>>   ?Auto-refine: + Final data parameters are stored in:
>> MultiBody/job1110/run_ct15_data.star
>>   ?Auto-refine: + Final resolution (without masking) is: 3.40645
>>   ?Auto-refine: + But you may want to run relion_postprocess to mask the
>> unfil.mrc maps and calculate a higher resolution FSC
>>
>> Last files produced:
>>
>> run_ct15_half2_body001_unfil.mrc
>> run_ct15_half2_body002_unfil.mrc
>> run_ct15_half1_body001_unfil.mrc
>> run_ct15_half1_body002_unfil.mrc
>> run_ct15_data.star
>> run_ct15_body001.mrc
>> run_ct15_body002.mrc
>> run_ct15_body001_angdist.bild
>> run_ct15_body002_angdist.bild
>> run_ct15_model.star
>> run_ct15_sampling.star
>> run.out
>>
>> After that there is no CPU activity, so it does not go into PCA step.
>>
>> Also, a combined map of two bodies together is not produced - should it
>> be?, or it needs to made separately, e.g. in Chimera?
>>
>> Thanks for your help!
>>
>> Leonid
>>
>> Prof. Leonid Sazanov
>> IST Austria
>> Am Campus 1
>> A-3400 Klosterneuburg
>> Austria
>>
>> Phone: +43 2243 9000 3026
>> E-mail: [log in to unmask]
>>
>> On 12/08/18 21:08, Takanori Nakane wrote:
>>> Hi,
>>>
>>> Yes, it should work without GPU.
>>>
>>> A MultiBody job proceeds in two steps.
>>>
>>> (1) multi-body refinement itself (relion_refine_mpi)
>>> (2) PCA analysis (relion_flex_analyser)
>>>
>>> Could you please look at the log file and see which step failed?
>>> Did the first step say "refinement has converged" and produce
>>> relevant STAR files?
>>>
>>> Best regards,
>>>
>>> Takanori Nakane
>>>
>>> On 2018/08/12 16:30, Leonid Sazanov wrote:
>>>> Hi, great new features in Relion3.0!
>>>>
>>>> A question - after running multibody refinement we don't get out the
>>>> results of PCA analysis, even though this option is set to "yes" in
>>>> GUI. The program stops but is not marked as finished. Is it supposed
>>>> to be working in CPU version of 3.0beta (the only one we have working
>>>> so far)?
>>>>
>>>> Many thanks!
>>>>
>>>> ########################################################################
>>>>
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>>>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1
>>>>
>> ########################################################################
>>
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>>
>

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========================================================================Date:         Wed, 15 Aug 2018 13:36:02 +0000
Reply-To:     David Bhella <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         David Bhella <[log in to unmask]>
Subject:      No orientation was found as better than any other.
Content-Type: text/plain; charset="us-ascii"
Content-Transfer-Encoding: quoted-printable
MIME-Version: 1.0
Message-ID:  <[log in to unmask]>

HI all,

I know this problem has been discussed previously, but I have hit a bump in the road that I am really struggling to get past.
I have successfully selected a particle dataset from 2D and 3D classification, but when I run Refine3D I get the following:

ERROR:
No orientation was found as better than any other.

A particle image was compared to the reference and resulted in all-zero
weights (for all orientations). This should not happen, unless your data
has very special characteristics. This has historically happened for some
lower-precision calculations, but multiple fallbacks have since been
implemented. Please report this error to the relion developers at

I have tried to use the new subset selection tools in Relion 3,0 to exclude particles with outlying statistics, defocus values, CTF figure of merit. To no avail.
I have also tried this on both single and double precision GPU and on CPU only (which failed giving a different error), as well as on Relion 2.1

I found that I could get one iteration to run if I set the reference to not be on absolute grey levels (which it should be as it was made in Relion). On the next iteration it failed though (presumably because now it was expected to be absolute values).

Has anyone come up with a foolproof way of weeding out the duff particles causing this problem?

Thanks,
D.



Dr David Bhella
Director - Scottish Centre for Macromolecular Imaging

MRC-University of Glasgow Centre for Virus Research
Sir Michael Stoker Building
Garscube Campus
464 Bearsden Road
Glasgow G61 1QH
Scotland (UK)

Telephone:  0141-330-3685
Skype: d.bhella

Virus structure group on Facebook: https://www.facebook.com/CVRstructure
Molecular Machines - Images from Virus Research: http://www.molecularmachines.org.uk

CVR website: http://www.cvr.ac.uk
CVR on Facebook: https://www.facebook.com/centreforvirusresearch



[University of Glasgow: The Times Scottish University of the Year 2018]

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========================================================================Date:         Wed, 15 Aug 2018 23:23:06 +0000
Reply-To:     Gregory Alushin <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Gregory Alushin <[log in to unmask]>
Subject:      Subtomogram averaging: FFT error in Relion-2.1.0
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DQo8L3A+DQo--_000_C61DC09EFBF244EEA66E1ADBA6D10794rockefelleredu_--
========================================================================Date:         Thu, 16 Aug 2018 11:17:28 +0200
Reply-To:     Sjors Scheres <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Sjors Scheres <[log in to unmask]>
Subject:      Re: adjusting power spectra in Relion
Comments: To: "Oosterheert, W. (Wout)" <[log in to unmask]>
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----_com.samsung.android.email_2843319582598910--
========================================================================Date:         Thu, 16 Aug 2018 14:15:02 +0200
Reply-To:     Dieter Blaas <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Dieter Blaas <[log in to unmask]>
Subject:      Re: Relion-2.1 continue Class3D run with subsets?
Comments: To: Takanori Nakane <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain; charset=UTF-8; format=flowed
Content-Transfer-Encoding: quoted-printable
Message-ID:  <[log in to unmask]>

Dear Takanori,

      I thought that the problem with the subsets would be solved in the 
new version but with Relion-3.0-beta-2 I still see the message: 
"WARNING: Option --fast_subsets    is not a valid RELION argument" when 
continuing a Class3D run. It does not seem to do any harm but apparently 
the message is superfluous or not?

bw Dieter

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: [log in to unmask]
------------------------------------------------------------------------

Am 19.06.2018 um 16:26 schrieb Takanori Nakane:
> Hi,
>
> This is a known problem of RELION 2.1 and will be fixed in the next version.
> Meanwhile, you can change _rlnSgdSubsetSize in optimiser.star to -1
> to disable subsets before continuing.
>
> Best regards,
>
> Takanori Nakane
>
>> Dear Sjors and all,
>>
>> when continuing a Class3D run (e.g. 10 classes) *with subsets* it starts
>> to make subsets again before it continues 'normally'. Is this on purpose
>> and if so, what does it use to make the subsets? I noticed that the
>> course of the separation into the classes was somewhat unexpected (one
>> class became much bigger as expected from the interrupted run and the
>> other ones became very small.
>>
>> Thanks, Dieter
>>
>> ------------------------------------------------------------------------
>> Dieter Blaas,
>> Max F. Perutz Laboratories
>> Medical University of Vienna,
>> Inst. Med. Biochem., Vienna Biocenter (VBC),
>> Dr. Bohr Gasse 9/3,
>> A-1030 Vienna, Austria,
>> Tel: 0043 1 4277 61630,
>> Fax: 0043 1 4277 9616,
>> e-mail: [log in to unmask]
>> ------------------------------------------------------------------------
>>
>>
>> ########################################################################
>>
>> To unsubscribe from the CCPEM list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
>>
>

########################################################################

To unsubscribe from the CCPEM list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
========================================================================Date:         Thu, 16 Aug 2018 14:44:17 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: Relion-2.1 continue Class3D run with subsets?
Comments: To: Dieter Blaas <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain;charset=iso-2022-jp
Content-Transfer-Encoding: 8bit
Message-ID:  <[log in to unmask]>

Hi,

Yes, you are right.

The program behaviour is fine but the message is superfluous.
I fixed the code and pushed to the repository.

Thank you for your feedback.

Best regards,

Takanori Nakane

> Dear Takanori,
>
>  ???? I thought that the problem with the subsets would be solved in the
> new version but with Relion-3.0-beta-2 I still see the message:
> "WARNING: Option --fast_subsets??? is not a valid RELION argument" when
> continuing a Class3D run. It does not seem to do any harm but apparently
> the message is superfluous or not?
>
> bw Dieter
>
> ------------------------------------------------------------------------
> Dieter Blaas,
> Max F. Perutz Laboratories
> Medical University of Vienna,
> Inst. Med. Biochem., Vienna Biocenter (VBC),
> Dr. Bohr Gasse 9/3,
> A-1030 Vienna, Austria,
> Tel: 0043 1 4277 61630,
> Fax: 0043 1 4277 9616,
> e-mail: [log in to unmask]
> ------------------------------------------------------------------------
>
> Am 19.06.2018 um 16:26 schrieb Takanori Nakane:
>> Hi,
>>
>> This is a known problem of RELION 2.1 and will be fixed in the next
>> version.
>> Meanwhile, you can change _rlnSgdSubsetSize in optimiser.star to -1
>> to disable subsets before continuing.
>>
>> Best regards,
>>
>> Takanori Nakane
>>
>>> Dear Sjors and all,
>>>
>>> when continuing a Class3D run (e.g. 10 classes) *with subsets* it
>>> starts
>>> to make subsets again before it continues 'normally'. Is this on
>>> purpose
>>> and if so, what does it use to make the subsets? I noticed that the
>>> course of the separation into the classes was somewhat unexpected (one
>>> class became much bigger as expected from the interrupted run and the
>>> other ones became very small.
>>>
>>> Thanks, Dieter
>>>
>>> ------------------------------------------------------------------------
>>> Dieter Blaas,
>>> Max F. Perutz Laboratories
>>> Medical University of Vienna,
>>> Inst. Med. Biochem., Vienna Biocenter (VBC),
>>> Dr. Bohr Gasse 9/3,
>>> A-1030 Vienna, Austria,
>>> Tel: 0043 1 4277 61630,
>>> Fax: 0043 1 4277 9616,
>>> e-mail: [log in to unmask]
>>> ------------------------------------------------------------------------
>>>
>>>
>>> ########################################################################
>>>
>>> To unsubscribe from the CCPEM list, click the following link:
>>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1
>>>
>>
>
> ########################################################################
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========================================================================Date:         Thu, 16 Aug 2018 19:50:18 +0000
Reply-To:     Gregory Alushin <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Gregory Alushin <[log in to unmask]>
Subject:      Re: Subtomogram averaging: FFT error in Relion-2.1.0
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========================================================================Date:         Fri, 17 Aug 2018 04:33:46 +0100
Reply-To:     SS <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         SS <[log in to unmask]>
Subject:      relion3: High-resolution 3D refinement
Mime-Version: 1.0
Content-Transfer-Encoding: quoted-printable
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Message-ID:  <[log in to unmask]>

I have a dataset, which I had originally processed through Relion2. I would now like to try the ctf refinement option in relion3. I was going through the tutorial and it mentions (in 5 High-resolution 3D refinement):

• Particle box size (pix) 360
(we will use a larger box, so that de-localised CTF signals can be better modeled. This is important for the CTF refinement later on.)
• Rescale particles? Yes
(to prevent working with very large images, let’s down-sample to a pixel size of 360*0.885/256=1.244 ˚A. This will limit our maximum achievable
resolution to 2.5 ËšA, which is probably enough for such a small data set.)

Does this mean:
a) Particle box size needs to be increased everytime, when we eventually need to do a ctf refinement?
b) or, this needs to be done, only when we intend to rescale the particles? 
c) Also, so far I have mostly decreased the box size, for down-sampling. Does, increasing the box size beyond the original box-size, have similar effect on pixel size? 


Thanks,

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========================================================================Date:         Thu, 16 Aug 2018 23:49:26 -0400
Reply-To:     leifu chang <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         leifu chang <[log in to unmask]>
Subject:      2018 Purdue Cryo-EM Symposium, Nov 6-8
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Dear Colleagues,



We are announcing the Purdue Cryo-EM Symposium to be held on November 6-8
2018. The goal of this meeting is to gather cryo-EM enthusiasts from around
the globe to discuss topics including sample preparation, data collection,
image processing and applications of cryo-EM. We will be hosting a range of
speakers that will share their recent progress and developments.
Application deadline is *Friday, August 31*. More details can be found in
the website of the symposium https://www.purdue.edu/cryoem2018/



*Keynote Speaker*

Richard Henderson (MRC Laboratory of Molecular Biology)



*Invited Speakers*

Yifan Cheng (UCSF)

Wah Chiu (Stanford University)

Tamir Gonen (UCLA)

Yuan He (Northwestern University)

Grant Jensen (Caltech)

Hong Jin (University of Illinois at Urbana–Champaign)

Werner Kühlbrandt (Max Planck Institute of Biophysics)

Jun Liu (Yale University)

Steven J Ludtke (Baylor College of Medicine)

Alfonso Mondragon (Northwestern University)

Daniela Nicastro (University of Texas Southwestern Medical Center)

Abbas Ourmazd (University of Wisconsin–Milwaukee)

Eduardo Perozo (University of Chicago)

Vinothkumar Kutti Ragunath (National Centre for Biological Sciences, India)

John Rubinstein (University of Toronto)

Phoebe Stewart (Case Western Reserve University)

Peijun Zhang (University of Oxford)

Minglei Zhao (University of Chicago)

Z. Hong Zhou (UCLA)



We look forward to meeting many of you in November.



Best wishes,

The Organizing Committee

Department of Biological Sciences, Purdue University

West Lafayette, IN 47906, USA



*Co-chairs*

Wen Jiang, Leifu Chang



*Committee members*

William Cramer, Richard Kuhn, Angeline Lyon, Nicholas Noinaj,

Michael Rossmann, Cynthia Stauffacher, John Tesmer

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<div dir="ltr">















<p class="MsoNormal">Dear Colleagues,<span></span></p>

<p class="MsoNormal"> <span></span></p>

<p class="MsoNormal">We are announcing the Purdue Cryo-EM Symposium to be held on
November 6-8 2018. The goal of this meeting is to gather cryo-EM enthusiasts
from around the globe to discuss topics including sample preparation, data
collection, image processing and applications of cryo-EM. We will be hosting a
range of speakers that will share their recent progress and developments.
Application deadline is <b>Friday, August
31</b>. More details can be found in the website of the symposium <a href="https://www.purdue.edu/cryoem2018/" target="_blank">https://www.purdue.edu/<wbr>cryoem2018/</a><span></span></p>

<p class="MsoNormal"><b> </b></p>

<p class="MsoNormal"><b>Keynote Speaker<span></span></b></p>

<p class="MsoNormal">Richard Henderson (MRC Laboratory of Molecular Biology)<span></span></p>

<p class="MsoNormal"> <span></span></p>

<p class="MsoNormal"><b>Invited Speakers<span></span></b></p>

<p class="MsoNormal">Yifan Cheng (UCSF)<span></span></p>

<p class="MsoNormal">Wah Chiu (Stanford University)<span></span></p>

<p class="MsoNormal">Tamir Gonen (UCLA)<span></span></p>

<p class="MsoNormal">Yuan He (Northwestern University)<span></span></p>

<p class="MsoNormal">Grant Jensen (Caltech)<span></span></p>

<p class="MsoNormal">Hong Jin (University of Illinois at Urbana–Champaign)<span></span></p>

<p class="MsoNormal">Werner Kühlbrandt (Max Planck Institute of Biophysics)<span></span></p>

<p class="MsoNormal">Jun Liu (Yale University)<span></span></p>

<p class="MsoNormal">Steven J Ludtke (Baylor College of Medicine)<span></span></p>

<p class="MsoNormal">Alfonso Mondragon (Northwestern University)<span></span></p>

<p class="MsoNormal">Daniela Nicastro (University of Texas Southwestern Medical
Center)<span></span></p>

<p class="MsoNormal">Abbas Ourmazd (University of Wisconsin–Milwaukee)<span></span></p>

<p class="MsoNormal">Eduardo Perozo (University of Chicago)<span></span></p>

<p class="MsoNormal">Vinothkumar Kutti Ragunath (National Centre for Biological
Sciences, India)<span></span></p>

<p class="MsoNormal">John Rubinstein (University of Toronto)<span></span></p>

<p class="MsoNormal">Phoebe Stewart (Case Western Reserve University)<span></span></p>

<p class="MsoNormal">Peijun Zhang (University of Oxford)<span></span></p>

<p class="MsoNormal">Minglei Zhao (University of Chicago)<span></span></p>

<p class="MsoNormal">Z. Hong Zhou (UCLA)<span></span></p>

<p class="MsoNormal"><span> </span></p>

<p class="MsoNormal">We look forward to meeting many of you in November. <span></span></p>

<p class="MsoNormal"><span> </span></p>

<p class="MsoNormal">Best wishes,<span></span></p>

<p class="MsoNormal">The Organizing Committee<span></span></p>

<p class="MsoNormal">Department of Biological Sciences, Purdue University<span></span></p>

<p class="MsoNormal">West Lafayette, IN 47906, USA<span></span></p>

<p class="MsoNormal"><span> </span></p>

<p class="MsoNormal"><i>Co-chairs<span></span></i></p>

<p class="MsoNormal">Wen Jiang, Leifu Chang<span></span></p>

<p class="MsoNormal"><span> </span></p>

<p class="MsoNormal"><i>Committee members<span></span></i></p>

<p class="MsoNormal">William Cramer, Richard Kuhn, Angeline Lyon, Nicholas
Noinaj, <span></span></p>

<p class="MsoNormal">Michael Rossmann, Cynthia Stauffacher, John Tesmer<span></span></p>

</div>
<br>
<hr>
<p align="center">To unsubscribe from the CCPEM list, click the following link:<br>
<a href="https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1" target="_blank">https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1</a>
</p>

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vszZM4jlDkYAAAAASUVORK5CYII--000000000000390eda05739972eb--
========================================================================Date:         Fri, 17 Aug 2018 10:48:52 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: relion3: High-resolution 3D refinement
Comments: To: SS <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain;charset=iso-2022-jp
Content-Transfer-Encoding: 7bit
Message-ID:  <[log in to unmask]>

Hi,

> a) Particle box size needs to be increased everytime, when we eventually
need to do a ctf refinement?
> b) or, this needs to be done, only when we intend to rescale the
particles?
> c) Also, so far I have mostly decreased the box size, for down-sampling.
Does, increasing the box size beyond the original box-size, have similar
effect on pixel size?

Your pixel size determines the Nyquist frequency. For example, if your
current resolution is 3 A and your pixel size is 1.4 A / pix, you are
very close to the limit. In such cases, you should re-extract in a smaller
pixel size.

The box size is another issue.

CTF causes signal de-localisation (= blurring) in the real space.
So your box has to include enough margins around the molecule.
The extent of de-localisation is larger at larger defoci and lower voltages.

Best regards,

Takanori Nakane

On 2018/08/17 4:33, SS wrote:
> I have a dataset, which I had originally processed through Relion2. I
would now like to try the ctf refinement option in relion3. I was going
through the tutorial and it mentions (in 5 High-resolution 3D
refinement):
> ? Particle box size (pix) 360
> (we will use a larger box, so that de-localised CTF signals can be
better modeled. This is important for the CTF refinement later on.)
> ? Rescale particles? Yes
> (to prevent working with very large images, let$B!G(Bs down-sample to a pixel size of 360*0.885/256=1.244 &#730;A. This will limit our maximum achievable
> resolution to 2.5 &#730;A, which is probably enough for such a small
data set.)
> Does this mean:
> a) Particle box size needs to be increased everytime, when we eventually
need to do a ctf refinement?
> b) or, this needs to be done, only when we intend to rescale the
particles?
> c) Also, so far I have mostly decreased the box size, for down-sampling.
Does, increasing the box size beyond the original box-size, have similar
effect on pixel size?
> Thanks,
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========================================================================Date:         Fri, 17 Aug 2018 11:32:25 +0000
Reply-To:     Tom Burnley - UKRI STFC <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Tom Burnley - UKRI STFC <[log in to unmask]>
Subject:      Job Opening - Computational Scientist - STFC / CCP-EM
Content-Type: text/plain; charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable
MIME-Version: 1.0
Message-ID:  <[log in to unmask]>

Dear all,


We are seeking a computational scientist, focusing on the application of machine learning to cryoEM.


This permintant position will be embedded in a new team in the Scientific Computing Department of STFC and based at the Rutherford Appleton Laboratory in Oxfordshire, UK, home to the Diamond Light Source, the ISIS Neutron and Muon Source and the Central Laser Facility.  The team will consistent of several developers who will apply machine learning to scientific data across multiple domains.  The EM specific role will be guided by CCP-EM and will work closely with the national EM facility (eBIC / DLS).  For informal enquiries please contact myself: Tom Burnley ([log in to unmask]) or Martyn Winn ([log in to unmask]).


All the best,


Tom


Job desciption:


This opening is a great opportunity that combines two of the most exciting subjects in life science: Machine Learning (ML) and cryo-electron microscopy (cryoEM).  Following recent progress in electron cryo-microscopy (cryo-EM), as recognised by the 2017 Nobel Prize in Chemistry, it is now possible to determine structures of biological macromolecules in atomic detail from images of molecules in frozen solution. This revolution has led to major investments in cryoEM, including at the Electron Bio-Imaging Centre (eBIC) at Diamond on the Harwell campus. Such facilities are generating large amounts of data daily, and the bottleneck has moved to data processing. At the same time, AI and machine learning techniques are coming of age, and promising fast and reliable data-driven analysis of data.

STFC have created the Scientific Machine Learning (SciML) group to focus efforts on applying the latest AI and machine learning techniques to large experimental datasets. This role, one of several being created in the SciML group, will develop and apply advanced data analytical techniques to cryoEM datasets, in close collaboration with eBIC.

Further details and application:

https://www.nature.com/naturejobs/science/jobs/650553-computational-scientist

http://www.topcareer.jobs/Vacancy/irc245954_8504.aspx

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========================================================================Date:         Sat, 18 Aug 2018 12:36:22 +0200
Reply-To:     Blaas Dieter <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Blaas Dieter <[log in to unmask]>
Subject:      Re: Relion-2.1 continue Class3D run with subsets?
Comments: To: Takanori Nakane <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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Hi Takanori and all,

    I have been running a Class3D without alignment (relion-3.0-beta-1)
on a 32 GB workstation to  3.668067 A. This was very useful to eliminate
bad particles; 3D auto-refine on the best class increased the resolution
by 0.2 A. However, the Class3D run did not output anything any more for
many hours after iteration 36. See the last message below.  The CPUs
continued running at about 100%:

============================ Expectation iteration 36 of 200
17.00/17.00 min
............................................................~~(,_,">
 Maximization ...
23.77/23.77 min
............................................................~~(,_,">

each previous iteration took only roughly 1 to 2 hours to complete. I
killed the run and continued at iteration 36 with exactly the same halt
of output as above.

Believing that it had to do with extensive swapping, I then continued
this run on a workstation with 128 GB. However, again nothing was
happening for hours after completion of iteration 36. I then killed the
run again and this time I continued from iteration 35. It went perfectly
well until iteration 36. Then again it stopped outputting anything. Can
anybody give me a hint as to what might be the reason for this behavior!
Please see attached the run.out file.

Thanks, Dieter

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: [log in to unmask]
------------------------------------------------------------------------

Am 16.08.2018 um 16:24 schrieb Takanori Nakane:

> Hi,
>
> I don't see the point of pushing the resolution during Class3D.
> Typically you don't need very high resolution for classification.
>
>> Maybe it is best to transfer the data onto another workstation that has
>
> 128 GB RAM?
>
> Yes. I recommend it.
>
> I don't know what happened at the particular iteration.
> Possibly the angular sampling became very fine?
>
> Best regards,
>
> Takanori Nakane
>
> Well, I cannot use GPUs as I am running without alignment. I did not try
> downsampling because I am pushing to the maximum resolution. Maybe it is
> best to transfer the data onto another workstation that has 128 GB RAM?
> I was only astonished about the abrupt change. As I said, until 3. 69 A
> or so it run perfectly well but as soon as it arrived at 6.66 it got
> stuck!
>
> bw Dieter
>
> ----------------------------------------------------2--------------------
> Dieter Blaas,
> Max F. Perutz Laboratories
> Medical University of Vienna,
> Inst. Med. Biochem., Vienna Biocenter (VBC),
> Dr. Bohr Gasse 9/3,
> A-1030 Vienna, Austria,
> Tel: 0043 1 4277 61630,
> Fax: 0043 1 4277 9616,
> e-mail: [log in to unmask]
> ------------------------------------------------------------------------
>
> Am 16.08.2018 um 16:10 schrieb Takanori Nakane:
>
> Hi,
>
> So you are not using any GPUs?
>
> If you are actually using 16 GB of swap, it is a bad sign. I don't think
> it will
> finish within any reasonable time. The 450 px diameter is also very big.
> For Class3D, you don't need very high resolution. Did you try
> down-sampling it?
>
> Best regards,
>
> Takanori Nakane
>
> OK, good! May I just add another question:
>
> I am running Class3D without alignment and each iteration took about
> 1-2
> hours. However, the last one is now running for more than 12 hours
> without even showing a forecast for the time to finish. I run it on a
> PC
> with only 32 GB and it uses 26 GB RAM and 16 GB SWAP. Is this the
> expected behavior for ~ 35000 images, 450 pix diameter and a current
> resolution of 3.66 A? Could it be that the PC is overwhelmed and cannot
> handle this? All 4 CPUs run to about 100%. I thought that it would help
> to kill the job and then continue. This is how I found what I sent you
> before....
>
> Thanks for hints, Dieter
>
> ------------------------------------------------------------------------
> Dieter Blaas,
> Max F. Perutz Laboratories
> Medical University of Vienna,
> Inst. Med. Biochem., Vienna Biocenter (VBC),
> Dr. Bohr Gasse 9/3,
> A-1030 Vienna, Austria,
> Tel: 0043 1 4277 61630,
> Fax: 0043 1 4277 9616,
> e-mail: [log in to unmask]
> ------------------------------------------------------------------------
>
> Am 16.08.2018 um 15:44 schrieb Takanori Nakane:
>
> Hi,
>
> Yes, you are right.
>
> The program behaviour is fine but the message is superfluous.
> I fixed the code and pushed to the repository.
>
> Thank you for your feedback.
>
> Best regards,
>
> Takanori Nakane
>
> Dear Takanori,
>
> ???? I thought that the problem with the subsets would be solved
> in
> the
> new version but with Relion-3.0-beta-2 I still see the message:
> "WARNING: Option --fast_subsets??? is not a valid RELION argument"
> when
> continuing a Class3D run. It does not seem to do any harm but
> apparently
> the message is superfluous or not?
>
> bw Dieter
>
> ------------------------------------------------------------------------
> Dieter Blaas,
> Max F. Perutz Laboratories
> Medical University of Vienna,
> Inst. Med. Biochem., Vienna Biocenter (VBC),
> Dr. Bohr Gasse 9/3,
> A-1030 Vienna, Austria,
> Tel: 0043 1 4277 61630,
> Fax: 0043 1 4277 9616,
> e-mail: [log in to unmask]
> ------------------------------------------------------------------------
>
> Am 19.06.2018 um 16:26 schrieb Takanori Nakane:
>
> Hi,
>
> This is a known problem of RELION 2.1 and will be fixed in the next
> version.
> Meanwhile, you can change _rlnSgdSubsetSize in optimiser.star to -1
> to disable subsets before continuing.
>
> Best regards,
>
> Takanori Nakane
>
> Dear Sjors and all,
>
> when continuing a Class3D run (e.g. 10 classes) *with subsets* it
> starts
> to make subsets again before it continues 'normally'. Is this on
> purpose
> and if so, what does it use to make the subsets? I noticed that the
> course of the separation into the classes was somewhat unexpected
> (one
> class became much bigger as expected from the interrupted run and
> the
> other ones became very small.
>
> Thanks, Dieter
>
> ------------------------------------------------------------------------
> Dieter Blaas,
> Max F. Perutz Laboratories
> Medical University of Vienna,
> Inst. Med. Biochem., Vienna Biocenter (VBC),
> Dr. Bohr Gasse 9/3,
> A-1030 Vienna, Austria,
> Tel: 0043 1 4277 61630,
> Fax: 0043 1 4277 9616,
> e-mail: [log in to unmask]
> ------------------------------------------------------------------------
>
> ########################################################################
>
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1

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--=_587b20f2a59456486942a9307352ec1b
Content-Transfer-Encoding: quoted-printable
Content-Type: text/html; charset=UTF-8

<html><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /></head><body style='font-size: 10pt; font-family: Verdana,Geneva,sans-serif'>
<p>Hi Takanori and all,</p>
<p>&nbsp;&nbsp;&nbsp; I have been running a Class3D without alignment (relion-3.0-beta-1) on a 32 GB workstation to&nbsp; 3.668067 A. This was very useful to eliminate bad particles; 3D auto-refine on the best class increased the resolution by 0.2 A. However, the Class3D run did not output anything any more for many hours after iteration 36. See the last message below.&nbsp; The CPUs continued running at about 100%:</p>
<p>=============================<br /> &nbsp;Expectation iteration 36 of 200<br /> 17.00/17.00 min ............................................................~~(,_,"&gt;<br /> &nbsp;Maximization ...<br /> 23.77/23.77 min ............................................................~~(,_,"&gt;</p>
<p>each previous iteration took only roughly 1 to 2 hours to complete. I killed the run and continued at iteration 36 with exactly the same halt of output as above. </p>
<p>Believing that it had to do with extensive swapping, I then continued this run on a workstation with 128 GB. However, again nothing was happening for hours after completion of iteration 36. I then killed the run again and this time I continued from iteration 35. It went perfectly well until iteration 36. Then again it stopped outputting anything. Can anybody give me a hint as to what might be the reason for this behavior! Please see attached the run.out file.</p>
<p>Thanks, Dieter</p>
<p><br /></p>
<pre class="moz-signature">------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna, 
Inst. Med. Biochem., Vienna Biocenter (VBC), 
Dr. Bohr Gasse 9/3, 
A-1030 Vienna, Austria, 
Tel: 0043 1 4277 61630, 
Fax: 0043 1 4277 9616, 
e-mail: <a class="moz-txt-link-abbreviated" href="mailto:[log in to unmask]">[log in to unmask]</a>
------------------------------------------------------------------------</pre>
<div class="moz-cite-prefix">Am 16.08.2018 um 16:24 schrieb Takanori Nakane:</div>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Hi,

I don't see the point of pushing the resolution during Class3D.
Typically you don't need very high resolution for classification.

</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Maybe it is best to transfer the data onto another workstation that has
</pre>
</blockquote>
<pre>128 GB RAM?

Yes. I recommend it.

I don't know what happened at the particular iteration.
Possibly the angular sampling became very fine?

Best regards,

Takanori Nakane

</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Well, I cannot use GPUs as I am running without alignment. I did not try
downsampling because I am pushing to the maximum resolution. Maybe it is
best to transfer the data onto another workstation that has 128 GB RAM?
I was only astonished about the abrupt change. As I said, until 3. 69 A
or so it run perfectly well but as soon as it arrived at 6.66 it got
stuck!

bw Dieter

----------------------------------------------------2--------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: <a class="moz-txt-link-abbreviated" href="mailto:[log in to unmask]">[log in to unmask]</a>
------------------------------------------------------------------------

Am 16.08.2018 um 16:10 schrieb Takanori Nakane:
</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Hi,

So you are not using any GPUs?

If you are actually using 16 GB of swap, it is a bad sign. I don't think
it will
finish within any reasonable time. The 450 px diameter is also very big.
For Class3D, you don't need very high resolution. Did you try
down-sampling it?

Best regards,

Takanori Nakane

</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>OK, good! May I just add another question:

I am running Class3D without alignment and each iteration took about
1-2
hours. However, the last one is now running for more than 12 hours
without even showing a forecast for the time to finish. I run it on a
PC
with only 32 GB and it uses 26 GB RAM and 16 GB SWAP. Is this the
expected behavior for ~ 35000 images, 450 pix diameter and a current
resolution of 3.66 A? Could it be that the PC is overwhelmed and cannot
handle this? All 4 CPUs run to about 100%. I thought that it would help
to kill the job and then continue. This is how I found what I sent you
before....

Thanks for hints, Dieter

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: <a class="moz-txt-link-abbreviated" href="mailto:[log in to unmask]">[log in to unmask]</a>
------------------------------------------------------------------------

Am 16.08.2018 um 15:44 schrieb Takanori Nakane:
</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Hi,

Yes, you are right.

The program behaviour is fine but the message is superfluous.
I fixed the code and pushed to the repository.

Thank you for your feedback.

Best regards,

Takanori Nakane

</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Dear Takanori,

   ???? I thought that the problem with the subsets would be solved
in
the
new version but with Relion-3.0-beta-2 I still see the message:
"WARNING: Option --fast_subsets??? is not a valid RELION argument"
when
continuing a Class3D run. It does not seem to do any harm but
apparently
the message is superfluous or not?

bw Dieter

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: <a class="moz-txt-link-abbreviated" href="mailto:[log in to unmask]">[log in to unmask]</a>
------------------------------------------------------------------------

Am 19.06.2018 um 16:26 schrieb Takanori Nakane:
</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Hi,

This is a known problem of RELION 2.1 and will be fixed in the next
version.
Meanwhile, you can change _rlnSgdSubsetSize in optimiser.star to -1
to disable subsets before continuing.

Best regards,

Takanori Nakane

</pre>
<blockquote type="cite" style="padding: 0 0.4em; border-left: #1010ff 2px solid; margin: 0">
<pre>Dear Sjors and all,

when continuing a Class3D run (e.g. 10 classes) *with subsets* it
starts
to make subsets again before it continues 'normally'. Is this on
purpose
and if so, what does it use to make the subsets? I noticed that the
course of the separation into the classes was somewhat unexpected
(one
class became much bigger as expected from the interrupted run and
the
other ones became very small.

Thanks, Dieter

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: <a class="moz-txt-link-abbreviated" href="mailto:[log in to unmask]">[log in to unmask]</a>
------------------------------------------------------------------------


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</pre>
</blockquote>
</blockquote>
<pre>&nbsp;</pre>
</blockquote>
<pre>&nbsp;</pre>
</blockquote>
<pre>&nbsp;</pre>
</blockquote>
<pre>&nbsp;</pre>
</blockquote>
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Q0NQRU0mQT0xDQo--=_06d032109cdd6aa0cf9e62a5fad73628--
========================================================================Date:         Sun, 19 Aug 2018 10:40:21 +0000
Reply-To:     Yehuda Halfon <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Yehuda Halfon <[log in to unmask]>
Subject:      Error loading relion 3
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Hi,

We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.

relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi


what are we doing wrong?

Thanks,


Yehuda Halfon

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<div style="direction: ltr;font-family: Tahoma;color: #000000;font-size: 10pt;">Hi,<br>
<br>
We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.
<br>
<br>
relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi<br>
<br>
<br>
what are we doing wrong? <br>
<br>
Thanks, <br>
<br>
<br>
Yehuda Halfon<br>
</div>
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</p>

--_000_01BBF0151AB05848A85DEBB14EE24C42389D7934ibwmbx03_--
========================================================================Date:         Mon, 20 Aug 2018 00:03:25 +0000
Reply-To:     Eric Hanssen <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Eric Hanssen <[log in to unmask]>
Subject:      multibody refinement
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Hi all,
I have ran a couple of semi successful multi body refinement (thank you for adding this feature in !) so far, some issues but I will keep this for another post.

I have tried to run another multibody with some slightly different condition (relaxing the auto sampling) one but it crashes on the last iteration with the following message (with no output mrc files) after running the :

The following warnings were encountered upon command-line parsing:
WARNING: Option --dont_check_norm                is not a valid RELION argument
  1: MPI_ERR_TRUNCATE: message truncated
  1: MPI_ERR_TRUNCATE: message truncated
in: /home/bio21em1/relion-3.0_beta/src/mpi.cpp, line 307
terminate called after throwing an instance of 'RelionError'
[odin:322907] *** Process received signal ***
[odin:322907] Signal: Aborted (6)
[odin:322907] Signal code:  (-6)
[odin:322907] [ 0] /lib64/libpthread.so.0[0x375c60f7e0]
[odin:322907] [ 1] /lib64/libc.so.6(gsignal+0x35)[0x375be32495]
[odin:322907] [ 2] /lib64/libc.so.6(abort+0x175)[0x375be33c75]
[odin:322907] [ 3] /usr/lib64/libstdc++.so.6(_ZN9__gnu_cxx27__verbose_terminate_handlerEv+0x12d)[0x3762abea7d]
[odin:322907] [ 4] /usr/lib64/libstdc++.so.6[0x3762abcbd6]
[odin:322907] [ 5] /usr/lib64/libstdc++.so.6[0x3762abcc03]
[odin:322907] [ 6] /usr/lib64/libstdc++.so.6[0x3762abcd22]
[odin:322907] [ 7] /usr/local/relion3/bin/relion_refine_mpi(_ZN7MpiNode16report_MPI_ERROREi+0x102)[0x488962]
[odin:322907] *** End of error message ***

If I then resume the run from the optimizer I get the unfil_half_maps created but it still crashes) with a very similar error

WARNING: Option --dont_check_norm                is not a valid RELION argument
  1: MPI_ERR_TRUNCATE: message truncated
  1: MPI_ERR_TRUNCATE: message truncated
in: /home/bio21em1/relion-3.0_beta/src/mpi.cpp, line 307
terminate called after throwing an instance of 'RelionError'
[odin:213947] *** Process received signal ***
[odin:213947] Signal: Aborted (6)
[odin:213947] Signal code:  (-6)
[odin:213947] [ 0] /lib64/libpthread.so.0[0x375c60f7e0]
[odin:213947] [ 1] /lib64/libc.so.6(gsignal+0x35)[0x375be32495]
[odin:213947] [ 2] /lib64/libc.so.6(abort+0x175)[0x375be33c75]
[odin:213947] [ 3] /usr/lib64/libstdc++.so.6(_ZN9__gnu_cxx27__verbose_terminate_handlerEv+0x12d)[0x3762abea7d]
[odin:213947] [ 4] /usr/lib64/libstdc++.so.6[0x3762abcbd6]
[odin:213947] [ 5] /usr/lib64/libstdc++.so.6[0x3762abcc03]
[odin:213947] [ 6] /usr/lib64/libstdc++.so.6[0x3762abcd22]
[odin:213947] [ 7] /usr/local/relion3/bin/relion_refine_mpi(_ZN7MpiNode16report_MPI_ERROREi+0x102)[0x488962]
[odin:213947] *** End of error message ***

I tried to run it on CPU only but it crashes even earlier

The following warnings were encountered upon command-line parsing:
WARNING: Option --dont_check_norm                is not a valid RELION argument
WARNING: Option --cpu              is not a valid RELION argument
XSIZE(pdf_direction)= 12288 rot_angles.size()= 49152
in: /home/bio21em1/relion-3.0_beta/src/healpix_sampling.cpp, line 1861
=== Backtrace  ===
/usr/local/relion3/bin/relion_refine_mpi(_ZN11RelionErrorC1ERKSsS1_l+0x41) [0x43bc61]
/usr/local/relion3/bin/relion_refine_mpi(_ZN15HealpixSampling38writeBildFileOrientationalDistributionER13MultidimArrayIdER8FileNameddPK8Matrix2DIdEPK8Matrix1DIdEdd+0xc2a) [0x5aceba]
/usr/local/relion3/bin/relion_refine_mpi(_ZN7MlModel5writeE8FileNameR15HealpixSamplingbb+0x493) [0x4adc83]
/usr/local/relion3/bin/relion_refine_mpi(_ZN11MlOptimiser5writeEbbbbi+0xf74) [0x4f4c24]
/usr/local/relion3/bin/relion_refine_mpi(_ZN14MlOptimiserMpi10initialiseEv+0x180e) [0x45ca3e]
/usr/local/relion3/bin/relion_refine_mpi(main+0xb0b) [0x43694b]
/lib64/libc.so.6(__libc_start_main+0xfd) [0x375be1ed1d]
/usr/local/relion3/bin/relion_refine_mpi() [0x42b9c9]
==================
ERROR:
HealpixSampling::writeBildFileOrientationalDistribution XSIZE(pdf_direction) != rot_angles.size()!

Thoughts?
Regard
Eric

-----------------
Assoc. Prof Eric Hanssen

Head - Advanced Microscopy Facility
Honorary Principal Fellow - Department of Biochemistry and Molecular Biology

Bio21 Molecular Science and Biotechnology Institute
30 Flemington Road - The University of Melbourne - Victoria 3010 - Australia
email: [log in to unmask]<mailto:[log in to unmask]> | Office: +61 3 83442449 | Microscope: +61 3 83442509
Web: www.microscopy.unimelb.edu.au<http://www.microscopy.unimelb.edu.au/>
[qqwd]



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<p class="MsoNormal">Hi all, <o:p></o:p></p>
<p class="MsoNormal">I have ran a couple of semi successful multi body refinement (thank you for adding this feature in !) so far, some issues but I will keep this for another post.
<o:p></o:p></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal">I have tried to run another multibody with some slightly different condition (relaxing the auto sampling) one but it crashes on the last iteration with the following message (with no output mrc files) after running the :<o:p></o:p></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal"><b>The following warnings were encountered upon command-line parsing:
<o:p></o:p></b></p>
<p class="MsoNormal"><b>WARNING: Option --dont_check_norm&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; is not a valid RELION argument<o:p></o:p></b></p>
<p class="MsoNormal"><b>&nbsp; 1: MPI_ERR_TRUNCATE: message truncated<o:p></o:p></b></p>
<p class="MsoNormal"><b>&nbsp; 1: MPI_ERR_TRUNCATE: message truncated<o:p></o:p></b></p>
<p class="MsoNormal"><b>in: /home/bio21em1/relion-3.0_beta/src/mpi.cpp, line 307<o:p></o:p></b></p>
<p class="MsoNormal"><b>terminate called after throwing an instance of 'RelionError'<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] *** Process received signal ***<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] Signal: Aborted (6)<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] Signal code:&nbsp; (-6)<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 0] /lib64/libpthread.so.0[0x375c60f7e0]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 1] /lib64/libc.so.6(gsignal&#43;0x35)[0x375be32495]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 2] /lib64/libc.so.6(abort&#43;0x175)[0x375be33c75]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 3] /usr/lib64/libstdc&#43;&#43;.so.6(_ZN9__gnu_cxx27__verbose_terminate_handlerEv&#43;0x12d)[0x3762abea7d]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 4] /usr/lib64/libstdc&#43;&#43;.so.6[0x3762abcbd6]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 5] /usr/lib64/libstdc&#43;&#43;.so.6[0x3762abcc03]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 6] /usr/lib64/libstdc&#43;&#43;.so.6[0x3762abcd22]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] [ 7] /usr/local/relion3/bin/relion_refine_mpi(_ZN7MpiNode16report_MPI_ERROREi&#43;0x102)[0x488962]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:322907] *** End of error message ***<o:p></o:p></b></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal">If I then resume the run from the optimizer I get the unfil_half_maps created but it still crashes) with a very similar error<o:p></o:p></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal"><b>WARNING: Option --dont_check_norm&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; is not a valid RELION argument<o:p></o:p></b></p>
<p class="MsoNormal"><b>&nbsp; 1: MPI_ERR_TRUNCATE: message truncated<o:p></o:p></b></p>
<p class="MsoNormal"><b>&nbsp; 1: MPI_ERR_TRUNCATE: message truncated<o:p></o:p></b></p>
<p class="MsoNormal"><b>in: /home/bio21em1/relion-3.0_beta/src/mpi.cpp, line 307<o:p></o:p></b></p>
<p class="MsoNormal"><b>terminate called after throwing an instance of 'RelionError'<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] *** Process received signal ***<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] Signal: Aborted (6)<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] Signal code:&nbsp; (-6)<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 0] /lib64/libpthread.so.0[0x375c60f7e0]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 1] /lib64/libc.so.6(gsignal&#43;0x35)[0x375be32495]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 2] /lib64/libc.so.6(abort&#43;0x175)[0x375be33c75]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 3] /usr/lib64/libstdc&#43;&#43;.so.6(_ZN9__gnu_cxx27__verbose_terminate_handlerEv&#43;0x12d)[0x3762abea7d]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 4] /usr/lib64/libstdc&#43;&#43;.so.6[0x3762abcbd6]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 5] /usr/lib64/libstdc&#43;&#43;.so.6[0x3762abcc03]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 6] /usr/lib64/libstdc&#43;&#43;.so.6[0x3762abcd22]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] [ 7] /usr/local/relion3/bin/relion_refine_mpi(_ZN7MpiNode16report_MPI_ERROREi&#43;0x102)[0x488962]<o:p></o:p></b></p>
<p class="MsoNormal"><b>[odin:213947] *** End of error message ***<o:p></o:p></b></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal">I tried to run it on CPU only but it crashes even earlier<o:p></o:p></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal"><b>The following warnings were encountered upon command-line parsing:
<o:p></o:p></b></p>
<p class="MsoNormal"><b>WARNING: Option --dont_check_norm&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; is not a valid RELION argument<o:p></o:p></b></p>
<p class="MsoNormal"><b>WARNING: Option --cpu&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; is not a valid RELION argument<o:p></o:p></b></p>
<p class="MsoNormal"><b>XSIZE(pdf_direction)= 12288 rot_angles.size()= 49152<o:p></o:p></b></p>
<p class="MsoNormal"><b>in: /home/bio21em1/relion-3.0_beta/src/healpix_sampling.cpp, line 1861<o:p></o:p></b></p>
<p class="MsoNormal"><b>=== Backtrace&nbsp; ===<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi(_ZN11RelionErrorC1ERKSsS1_l&#43;0x41) [0x43bc61]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi(_ZN15HealpixSampling38writeBildFileOrientationalDistributionER13MultidimArrayIdER8FileNameddPK8Matrix2DIdEPK8Matrix1DIdEdd&#43;0xc2a) [0x5aceba]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi(_ZN7MlModel5writeE8FileNameR15HealpixSamplingbb&#43;0x493) [0x4adc83]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi(_ZN11MlOptimiser5writeEbbbbi&#43;0xf74) [0x4f4c24]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi(_ZN14MlOptimiserMpi10initialiseEv&#43;0x180e) [0x45ca3e]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi(main&#43;0xb0b) [0x43694b]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/lib64/libc.so.6(__libc_start_main&#43;0xfd) [0x375be1ed1d]<o:p></o:p></b></p>
<p class="MsoNormal"><b>/usr/local/relion3/bin/relion_refine_mpi() [0x42b9c9]<o:p></o:p></b></p>
<p class="MsoNormal"><b>==================<o:p></o:p></b></p>
<p class="MsoNormal"><b>ERROR: <o:p></o:p></b></p>
<p class="MsoNormal"><b>HealpixSampling::writeBildFileOrientationalDistribution XSIZE(pdf_direction) != rot_angles.size()!<o:p></o:p></b></p>
<p class="MsoNormal"><b><o:p>&nbsp;</o:p></b></p>
<p class="MsoNormal">Thoughts?<br>
Regard<o:p></o:p></p>
<p class="MsoNormal">Eric<o:p></o:p></p>
<p class="MsoNormal"><b><o:p>&nbsp;</o:p></b></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:navy;mso-fareast-language:EN-AU">-----------------<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:navy;mso-fareast-language:EN-AU">Assoc. Prof Eric Hanssen<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:navy;mso-fareast-language:EN-AU"><o:p>&nbsp;</o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:#1F497D;mso-fareast-language:EN-AU">Head - Advanced Microscopy Facility
</span></b><b><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:#1F497D;mso-fareast-language:EN-AU"><o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:#1F497D;mso-fareast-language:EN-AU">Honorary Principal Fellow &#8211; Department of Biochemistry and Molecular Biology<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:#1F497D;mso-fareast-language:EN-AU"><br>
Bio21 Molecular Science and Biotechnology Institute<br>
</span><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:gray;mso-fareast-language:EN-AU">30 Flemington Road - The University of Melbourne - Victoria 3010 - Australia<br>
email: </span><span style="color:#1F497D;mso-fareast-language:EN-AU"><a href="mailto:[log in to unmask]"><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:gray">[log in to unmask]</span></a></span><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:gray;mso-fareast-language:EN-AU">
 | Office: &#43;61 3 83442449&nbsp;| Microscope: &#43;61 3 83442509 <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:&quot;Comic Sans MS&quot;;color:gray;mso-fareast-language:EN-AU">Web:
<a href="http://www.microscopy.unimelb.edu.au/">www.microscopy.unimelb.edu.au</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-AU"><img border="0" width="624" height="290" id="Picture_x0020_1" src="cid:image001.png@01D4386B.F22D2CD0" alt="qqwd"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-AU"><o:p>&nbsp;</o:p></span></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
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Content-Description: run.out
Content-Disposition: attachment; filename="run.out"; size24710;
	creation-date="Mon, 20 Aug 2018 00:01:09 GMT";
	modification-date="Mon, 20 Aug 2018 00:03:25 GMT"
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========================================================================Date:         Mon, 20 Aug 2018 06:41:29 +0000
Reply-To:     Daniel Larsson <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Daniel Larsson <[log in to unmask]>
Subject:      Re: Error loading relion 3
Comments: To: Yehuda Halfon <[log in to unmask]>
In-Reply-To:  <01BBF0151AB05848A85DEBB14EE24C42389D7934@ibwmbx03>
Content-Type: multipart/alternative;
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Message-ID:  <[log in to unmask]>

--_000_2A1739AF74CF46FB921C910DC9D6A81Cicmuuse_
Content-Type: text/plain; charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable

Dear Yehuda,

I also ran into this exact problem (https://github.com/3dem/relion/issues/384#issuecomment-413902038). I solved it by re-compiling with local FLTK library, i.e. 'cmake -DFORCE_OWN_FLTK=ON [other flags] ..'. This only affects the main GUI and I think the tools works fine.

Good luck!

Regards,
Daniel



On 2018-08-19, at 12:40, Yehuda Halfon <[log in to unmask]<mailto:[log in to unmask]>> wrote:

Hi,

We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.

relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi


what are we doing wrong?

Thanks,


Yehuda Halfon

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--_000_2A1739AF74CF46FB921C910DC9D6A81Cicmuuse_
Content-Type: text/html; charset="iso-8859-1"
Content-ID: <[log in to unmask]>
Content-Transfer-Encoding: quoted-printable

<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
</head>
<body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">
<div class="">Dear Yehuda,</div>
<div class=""><br class="">
</div>
<div class="">I also ran into this exact problem (<a href="https://github.com/3dem/relion/issues/384#issuecomment-413902038" class="">https://github.com/3dem/relion/issues/384#issuecomment-413902038</a>). I solved it by re-compiling with local FLTK library,
 i.e. 'cmake -DFORCE_OWN_FLTK=ON [other flags] ..'. This only affects the main GUI and I think the tools works fine.</div>
<div class=""><br class="">
</div>
<div class="">Good luck!</div>
<div class=""><br class="">
</div>
<div class="">Regards,</div>
<div class="">Daniel</div>
<div class=""><br class="">
</div>
<div class=""><br class="">
</div>
<div class=""><br class="">
</div>
<div>
<blockquote type="cite" class="">
<div class="">On 2018-08-19, at 12:40, Yehuda Halfon &lt;<a href="mailto:[log in to unmask]" class="">[log in to unmask]</a>&gt; wrote:</div>
<br class="Apple-interchange-newline">
<div class="">
<div style="font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px; direction: ltr; font-family: Tahoma; font-size: 10pt;" class="">
Hi,<br class="">
<br class="">
We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.<span class="Apple-converted-space">&nbsp;</span><br class="">
<br class="">
relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi<br class="">
<br class="">
<br class="">
what are we doing wrong?<span class="Apple-converted-space">&nbsp;</span><br class="">
<br class="">
Thanks,<span class="Apple-converted-space">&nbsp;</span><br class="">
<br class="">
<br class="">
Yehuda Halfon<br class="">
</div>
<br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px;" class="">
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--_000_2A1739AF74CF46FB921C910DC9D6A81Cicmuuse_--
========================================================================Date:         Mon, 20 Aug 2018 06:46:51 +0000
Reply-To:     Yehuda Halfon <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Yehuda Halfon <[log in to unmask]>
Subject:      Re: Error loading relion 3
Comments: To: "[log in to unmask]" <[log in to unmask]>
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========================================================================Date:         Mon, 20 Aug 2018 08:25:24 +0000
Reply-To:     Yehuda Halfon <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Yehuda Halfon <[log in to unmask]>
Subject:      Re: Error loading relion 3
In-Reply-To:  <[log in to unmask]>
Content-Type: multipart/alternative;
              boundary="_000_01BBF0151AB05848A85DEBB14EE24C42389D7EA9ibwmbx03_"
MIME-Version: 1.0
Message-ID:  <01BBF0151AB05848A85DEBB14EE24C42389D7EA9@ibwmbx03>

--_000_01BBF0151AB05848A85DEBB14EE24C42389D7EA9ibwmbx03_
Content-Type: text/plain; charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable

Hi All,

It works we needed to re compile it since relion didn't like the OS version of FLTK. Thanks a lot.

Yehuda
________________________________
From: Collaborative Computational Project in Electron cryo-Microscopy [[log in to unmask]] on behalf of Yehuda Halfon
Sent: Monday, August 20, 2018 9:46 AM
To: [log in to unmask]
Subject: Re: [ccpem] Error loading relion 3


Hi Daniel,

I'll give it a try and will update.

Yehuda Halfon


-------- Original Message --------
From: Daniel Larsson <[log in to unmask]>
Sent: Monday, August 20, 2018 09:41 AM
To: Yehuda Halfon <[log in to unmask]>
Subject: Re: [ccpem] Error loading relion 3
CC: [log in to unmask]

Dear Yehuda,

I also ran into this exact problem (https://github.com/3dem/relion/issues/384#issuecomment-413902038). I solved it by re-compiling with local FLTK library, i.e. 'cmake -DFORCE_OWN_FLTK=ON [other flags] ..'. This only affects the main GUI and I think the tools works fine.

Good luck!

Regards,
Daniel



On 2018-08-19, at 12:40, Yehuda Halfon <[log in to unmask]<mailto:[log in to unmask]>> wrote:

Hi,

We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.

relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi


what are we doing wrong?

Thanks,


Yehuda Halfon

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<div style="direction: ltr;font-family: Tahoma;color: #000000;font-size: 10pt;">Hi All,
<div><br>
</div>
<div>It works we needed to re compile it since relion didn't like the OS version of FLTK. Thanks a lot.</div>
<div><br>
</div>
<div>Yehuda<br>
<div style="font-family: Times New Roman; color: #000000; font-size: 16px">
<hr tabindex="-1">
<div id="divRpF86220" style="direction: ltr;"><font face="Tahoma" size="2" color="#000000"><b>From:</b> Collaborative Computational Project in Electron cryo-Microscopy [[log in to unmask]] on behalf of Yehuda Halfon<br>
<b>Sent:</b> Monday, August 20, 2018 9:46 AM<br>
<b>To:</b> [log in to unmask]<br>
<b>Subject:</b> Re: [ccpem] Error loading relion 3<br>
</font><br>
</div>
<div></div>
<div>
<p dir="ltr">Hi Daniel,</p>
<p dir="ltr">I'll give it a try and will update.</p>
<p dir="ltr">Yehuda Halfon </p>
<br>
<br>
-------- Original Message --------<br>
From: Daniel Larsson &lt;[log in to unmask]&gt;<br>
Sent: Monday, August 20, 2018 09:41 AM<br>
To: Yehuda Halfon &lt;[log in to unmask]&gt;<br>
Subject: Re: [ccpem] Error loading relion 3<br>
CC: [log in to unmask]<br>
<br>
<div class="">Dear Yehuda,</div>
<div class=""><br class="">
</div>
<div class="">I also ran into this exact problem (<a href="https://github.com/3dem/relion/issues/384#issuecomment-413902038" class="" target="_blank">https://github.com/3dem/relion/issues/384#issuecomment-413902038</a>). I solved it by re-compiling with local
 FLTK library, i.e. 'cmake -DFORCE_OWN_FLTK=ON [other flags] ..'. This only affects the main GUI and I think the tools works fine.</div>
<div class=""><br class="">
</div>
<div class="">Good luck!</div>
<div class=""><br class="">
</div>
<div class="">Regards,</div>
<div class="">Daniel</div>
<div class=""><br class="">
</div>
<div class=""><br class="">
</div>
<div class=""><br class="">
</div>
<div>
<blockquote type="cite" class="">
<div class="">On 2018-08-19, at 12:40, Yehuda Halfon &lt;<a href="mailto:[log in to unmask]" class="" target="_blank">[log in to unmask]</a>&gt; wrote:</div>
<br class="Apple-interchange-newline">
<div class="">
<div class="" style="font-style:normal; font-weight:normal; letter-spacing:normal; orphans:auto; text-align:start; text-indent:0px; text-transform:none; white-space:normal; widows:auto; word-spacing:0px; direction:ltr; font-family:Tahoma; font-size:10pt">
Hi,<br class="">
<br class="">
We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.<span class="Apple-converted-space">&nbsp;</span><br class="">
<br class="">
relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi<br class="">
<br class="">
<br class="">
what are we doing wrong?<span class="Apple-converted-space">&nbsp;</span><br class="">
<br class="">
Thanks,<span class="Apple-converted-space">&nbsp;</span><br class="">
<br class="">
<br class="">
Yehuda Halfon<br class="">
</div>
<br class="" style="font-family:Helvetica; font-size:12px; font-style:normal; font-weight:normal; letter-spacing:normal; orphans:auto; text-align:start; text-indent:0px; text-transform:none; white-space:normal; widows:auto; word-spacing:0px">
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<br>
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--_000_01BBF0151AB05848A85DEBB14EE24C42389D7EA9ibwmbx03_--
========================================================================Date:         Mon, 20 Aug 2018 09:54:00 +0100
Reply-To:     Russell Nathan Hyer <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
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Subject:      Re: CCPEM Digest - 18 Aug 2018 to 19 Aug 2018 (#2018-205)
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Hi Yehuda,

The error that you're getting is not-so-secretly an error reported by the GUI library that relion is built using. That GUI (or graphical user interface) library is called FLTK (see fltk.org). For the specific function, there's not much documentation available at [1]

As you get a symbol undefined problem is the issue really that the source won't compile? In which case you'll likely need the libfltk dev library and to add the appropriate switch at compile time to select that library.

b'shalom

Russell

[1] http://www.fltk.org/documentation.php/doc-1.1/Fl_Browser_.html#Fl_Browser_.textsize

On Mon, 20 Aug 2018 00:00:38 +0100, CCPEM automatic digest system <[log in to unmask]> wrote:

> There is 1 message totaling 73 lines in this issue.
> 
> Topics of the day:
> 
>   1. Error loading relion 3
> 
> ########################################################################
> 
> To unsubscribe from the CCPEM list, click the following link:
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> 
> ----------------------------------------------------------------------
> 
> Date:    Sun, 19 Aug 2018 10:40:21 +0000
> From:    Yehuda Halfon <[log in to unmask]>
> Subject: Error loading relion 3
> 
> Hi,
> 
> We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.
> 
> relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi
> 
> 
> what are we doing wrong?
> 
> Thanks,
> 
> 
> Yehuda Halfon
> 
> ########################################################################
> 
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
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> ------------------------------
> 
> End of CCPEM Digest - 18 Aug 2018 to 19 Aug 2018 (#2018-205)
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========================================================================Date:         Mon, 20 Aug 2018 10:04:34 +0100
Reply-To:     Russell Nathan Hyer <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Russell Nathan Hyer <[log in to unmask]>
Subject:      Re: CCPEM Digest - 18 Aug 2018 to 19 Aug 2018 (#2018-205)
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Hi Yehuda,

So according to the BuildFLTK.cmake[1] file you would need to run cmake BuildFLTK.cmake whilst connected to the internet as a first prerequisite as this will check if you have it installed already (and download it so that you can complete the rest of the installation).

Russell
[1] https://github.com/3dem/relion/blob/master/cmake/BuildFLTK.cmake

On Mon, 20 Aug 2018 09:54:00 +0100 (BST), "Russell Nathan Hyer" <[log in to unmask]> wrote:

> Hi Yehuda,
> 
> The error that you're getting is not-so-secretly an error reported by the GUI library that relion is built using. That GUI (or graphical user interface) library is called FLTK (see fltk.org). For the specific function, there's not much documentation available at [1]
> 
> As you get a symbol undefined problem is the issue really that the source won't compile? In which case you'll likely need the libfltk dev library and to add the appropriate switch at compile time to select that library.
> 
> b'shalom
> 
> Russell
> 
> [1] http://www.fltk.org/documentation.php/doc-1.1/Fl_Browser_.html#Fl_Browser_.textsize
> 
> On Mon, 20 Aug 2018 00:00:38 +0100, CCPEM automatic digest system <[log in to unmask]> wrote:
> 
> > There is 1 message totaling 73 lines in this issue.
> > 
> > Topics of the day:
> > 
> >   1. Error loading relion 3
> > 
> > ########################################################################
> > 
> > To unsubscribe from the CCPEM list, click the following link:
> > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
> > 
> > ----------------------------------------------------------------------
> > 
> > Date:    Sun, 19 Aug 2018 10:40:21 +0000
> > From:    Yehuda Halfon <[log in to unmask]>
> > Subject: Error loading relion 3
> > 
> > Hi,
> > 
> > We installed relion 3.0 on our workstation (that run relion 2.1 perfectly) and we get this error.
> > 
> > relion: symbol lookup error: relion: undefined symbol: _ZN10Fl_Browser8textsizeEi
> > 
> > 
> > what are we doing wrong?
> > 
> > Thanks,
> > 
> > 
> > Yehuda Halfon
> > 
> > ########################################################################
> > 
> > To unsubscribe from the CCPEM list, click the following link:
> > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
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> > ------------------------------
> > 
> > End of CCPEM Digest - 18 Aug 2018 to 19 Aug 2018 (#2018-205)
> > ************************************************************

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========================================================================Date:         Mon, 20 Aug 2018 15:12:02 +0000
Reply-To:     "Daum, Bertram" <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         "Daum, Bertram" <[log in to unmask]>
Subject:      Postdoc opportunity in Exeter, UK
Comments: To: "[log in to unmask]" <[log in to unmask]>,
          "[log in to unmask]" <[log in to unmask]>
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Dear all,

A EU-funded position for a Postdoctoral Research Assistant is available in the group of Dr. Bertram Daum at the Living Systems Institute, University of Exeter.

The successful candidate will employ biochemistry, electron cryo-tomography and single particle electron microscopy to study the structure and function of prokaryotic surface layers and filaments for applications in synthetic biology and micro-robotics. Our institute is equipped with brand new sample preparation laboratories, an automated and cryo-capable screening microscope with CMOS detector, a dedicated high-performance computer cluster for image processing and 3D visualisation workstations. The candidate will also have regular access to our shared GW4 200 kV Talos Arctica with a K2 direct electron detector, and to 300kV Titan Krios microscopes at core facilities.

Closing date for applications is 27th August 2018.

For further information please see here

https://jobs.exeter.ac.uk/hrpr_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=796076MUQp&WVID=3817591jNg&LANG=USA

Best regards,
Bertram


--
Dr Bertram Daum
Research Fellow
University of Exeter

+441392727455
www.exeter.ac.uk<http://www.exeter.ac.uk>

Living Systems Institute
Stocker Road
Exeter
Devon
EX4 4QD
United Kingdom


--
Dr Bertram Daum
Research Fellow
University of Exeter

+441392727455
www.exeter.ac.uk<http://www.exeter.ac.uk>

Living Systems Institute
Stocker Road
Exeter
Devon
EX4 4QD
United Kingdom



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<div class="">Dear all,<br class="">
<br class="">
A EU-funded position for a&nbsp;Postdoctoral Research Assistant&nbsp;is available in the group of Dr. Bertram Daum at the Living Systems Institute, University of Exeter.<br class="">
<br class="">
The successful candidate will employ biochemistry, electron cryo-tomography and single particle electron microscopy to study the structure and function of prokaryotic surface layers and filaments for applications in synthetic biology and micro-robotics. Our&nbsp;institute
 is equipped with brand new sample preparation laboratories, an automated and cryo-capable screening microscope with CMOS detector, a dedicated high-performance computer cluster for image processing and 3D visualisation workstations. The candidate will also
 have regular access to our&nbsp;shared GW4 200 kV Talos Arctica with a K2 direct electron detector, and to 300kV Titan Krios microscopes at core facilities.<br class="">
<br class="">
Closing date for applications is 27th August 2018.<br class="">
<br class="">
For further information please see&nbsp;here<br class="">
<br class="">
<a href="https://jobs.exeter.ac.uk/hrpr_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=796076MUQp&amp;WVID=3817591jNg&amp;LANG=USA" class="">https://jobs.exeter.ac.uk/hrpr_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=796076MUQp&amp;WVID=3817591jNg&amp;LANG=USA</a><br class="">
<br class="">
Best regards,<br class="">
Bertram&nbsp;</div>
<div class=""><br class="">
</div>
<div class=""><br class="">
</div>
<div class="">--</div>
<div class="">
<div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">
<div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">
<div class="">Dr Bertram Daum<br class="">
Research Fellow<br class="">
University of Exeter&nbsp;<br class="">
<br class="">
&#43;441392727455<br class="">
<a href="http://www.exeter.ac.uk" class="">www.exeter.ac.uk</a><br class="">
<br class="">
Living Systems Institute&nbsp;<br class="">
Stocker Road&nbsp;<br class="">
Exeter<br class="">
Devon<br class="">
EX4 4QD<br class="">
United Kingdom</div>
</div>
</div>
</div>
</div>
<div class=""><br class="">
</div>
<br class="">
<div class="">
<div style="color: rgb(0, 0, 0); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">
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<div class="">--<br class="">
Dr Bertram Daum<br class="">
Research Fellow<br class="">
University of Exeter&nbsp;<br class="">
<br class="">
&#43;441392727455<br class="">
<a href="http://www.exeter.ac.uk" class="">www.exeter.ac.uk</a><br class="">
<br class="">
Living Systems Institute&nbsp;<br class="">
Stocker Road&nbsp;<br class="">
Exeter<br class="">
Devon<br class="">
EX4 4QD<br class="">
United Kingdom<br class="">
<br class="">
</div>
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--_000_C0680168BF104188B2895A487740F8D9exeteracuk_--
========================================================================Date:         Mon, 20 Aug 2018 20:52:28 +0000
Reply-To:     "Breuer, Alex" <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         "Breuer, Alex" <[log in to unmask]>
Subject:      Relion, multi-node multi-GPU and NVLink
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Hi All,
My institution is spec-ing out a machine to process CryoEM data, which leads to the following question:


  1.  How is multi-node multi-GPU supported in Relion?  If not, is extending Relion to support this trivial?  Would this be a task that, say, a graduate student could complete in a few semesters?
  2.  How is NVLink utilized by Relion?  That is, does Relion explicitly exploit NVLink, rather than just getting NVLink acceleration for free via a cudaMemcpy()?
  3.  Combining 1. & 2.: does/can Relion use NVLink for iternode communication between GPUs?

Any information, complete or partial, would be most helpful and deeply appreciated.
Best,
Alex Breuer


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<body lang="EN-US" link="#0563C1" vlink="#954F72">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:11.0pt">Hi All,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">My institution is spec-ing out a machine to process CryoEM data, which leads to the following question:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p>&nbsp;</o:p></span></p>
<ol style="margin-top:0in" start="1" type="1">
<li class="MsoNormal" style="margin-left:0in;mso-list:l0 level1 lfo1"><span style="font-size:11.0pt">How is multi-node multi-GPU supported in Relion?&nbsp; If not, is extending Relion to support this trivial?&nbsp; Would this be a task that, say, a graduate student could
 complete in a few semesters?<o:p></o:p></span></li><li class="MsoNormal" style="margin-left:0in;mso-list:l0 level1 lfo1"><span style="font-size:11.0pt">How is NVLink utilized by Relion?&nbsp; That is, does Relion explicitly exploit NVLink, rather than just getting NVLink acceleration for free via a cudaMemcpy()?<o:p></o:p></span></li><li class="MsoNormal" style="margin-left:0in;mso-list:l0 level1 lfo1"><span style="font-size:11.0pt">Combining 1. &amp; 2.: does/can Relion use NVLink for iternode communication between GPUs?<o:p></o:p></span></li></ol>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p>&nbsp;</o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Any information, complete or partial, would be most helpful and deeply appreciated.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Alex Breuer<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p>&nbsp;</o:p></span></p>
</div>
<br>
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--_000_DM5PR04MB049181E1B5CA1A5BEABF35079E320DM5PR04MB0491namp_--
========================================================================Date:         Mon, 20 Aug 2018 23:17:50 +0200
Reply-To:     Erik Lindahl <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Erik Lindahl <[log in to unmask]>
Subject:      Re: Relion, multi-node multi-GPU and NVLink
Comments: To: [log in to unmask]
In-Reply-To:  <[log in to unmask]>
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Hi Alex,

On Mon, Aug 20, 2018 at 11:02 PM Breuer, Alex <[log in to unmask]>
wrote:

>
>
>    1. How is multi-node multi-GPU supported in Relion?  If not, is
>    extending Relion to support this trivial?  Would this be a task that, say,
>    a graduate student could complete in a few semesters?
>
> It works just fine in RELION, with the caveat that you might need some
fairly beefy fileservers and SSD caches to deliver data fast enough if you
are e.g. using four servers with four cards each.


>
>    1.
>    2. How is NVLink utilized by Relion?  That is, does Relion explicitly
>    exploit NVLink, rather than just getting NVLink acceleration for free via a
>    cudaMemcpy()?
>
> It doesn't at the moment. First, it's important to separate NVLINK
marketing from reality: Unless you have an IBM Power9 machine, you will
NEVER have any NVLINK acceleration between the CPU & GPU.

For RELION, processing images per se is a perfectly parallel process, and
then we simply read the images onto separate GPUs. We are thinking of ways
to use NVLINK to effectively expand the available memory, but then the
problem is that NVLINK is *WAY* slower than accessing memory locally on the
GPU, so it is not a magic solution that just doubles your memory.


>    1.
>    2. Combining 1. & 2.: does/can Relion use NVLink for iternode
>    communication between GPUs?
>
> NVLINK itself only works for direct communication between GPUs in the same
node, never internode.

Cheers,

Erik
--
Erik Lindahl <[log in to unmask]>
Professor of Biophysics, Dept. Biochemistry & Biophysics, Stockholm
University
Science for Life Laboratory, Box 1031, 17121 Solna, Sweden

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<div dir="ltr">Hi Alex,<br><br><div class="gmail_quote"><div dir="ltr">On Mon, Aug 20, 2018 at 11:02 PM Breuer, Alex &lt;<a href="mailto:[log in to unmask]" target="_blank">[log in to unmask]</a>&gt; wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">





<div lang="EN-US" link="#0563C1" vlink="#954F72">
<div class="m_5415908062406416121m_-6527803739542379633WordSection1">
<p class="MsoNormal"><br></p>
<ol style="margin-top:0in" start="1" type="1">
<li class="MsoNormal" style="margin-left:0in"><span style="font-size:11.0pt">How is multi-node multi-GPU supported in Relion?  If not, is extending Relion to support this trivial?  Would this be a task that, say, a graduate student could
 complete in a few semesters?</span></li></ol></div></div></blockquote><div>It works just fine in RELION, with the caveat that you might need some fairly beefy fileservers and SSD caches to deliver data fast enough if you are e.g. using four servers with four cards each.</div><div> <br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div lang="EN-US" link="#0563C1" vlink="#954F72"><div class="m_5415908062406416121m_-6527803739542379633WordSection1"><ol style="margin-top:0in" start="1" type="1"><li class="MsoNormal" style="margin-left:0in"><span style="font-size:11.0pt"><u></u><u></u></span></li><li class="MsoNormal" style="margin-left:0in"><span style="font-size:11.0pt">How is NVLink utilized by Relion?  That is, does Relion explicitly exploit NVLink, rather than just getting NVLink acceleration for free via a cudaMemcpy()?</span></li></ol></div></div></blockquote><div>It doesn&#39;t at the moment. First, it&#39;s important to separate NVLINK marketing from reality: Unless you have an IBM Power9 machine, you will NEVER have any NVLINK acceleration between the CPU &amp; GPU.</div><div><br></div><div>For RELION, processing images per se is a perfectly parallel process, and then we simply read the images onto separate GPUs. We are thinking of ways to use NVLINK to effectively expand the available memory, but then the problem is that NVLINK is *WAY* slower than accessing memory locally on the GPU, so it is not a magic solution that just doubles your memory.<br></div><div><br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div lang="EN-US" link="#0563C1" vlink="#954F72"><div class="m_5415908062406416121m_-6527803739542379633WordSection1"><ol style="margin-top:0in" start="1" type="1"><li class="MsoNormal" style="margin-left:0in"><span style="font-size:11.0pt"><u></u><u></u></span></li><li class="MsoNormal" style="margin-left:0in"><span style="font-size:11.0pt">Combining 1. &amp; 2.: does/can Relion use NVLink for iternode communication between GPUs?</span></li></ol></div></div></blockquote><div>NVLINK itself only works for direct communication between GPUs in the same node, never internode.</div><div><br></div><div>Cheers,</div><div><br></div><div>Erik <br></div></div>-- <br><div dir="ltr" class="m_5415908062406416121gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div>Erik Lindahl &lt;<a href="mailto:[log in to unmask]" target="_blank">[log in to unmask]</a>&gt;</div><div>Professor of Biophysics, Dept. Biochemistry &amp; Biophysics, Stockholm University</div><div>Science for Life Laboratory, Box 1031, 17121 Solna, Sweden</div></div></div></div></div></div></div></div></div></div>
<br>
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--000000000000c581db0573e47106--
========================================================================Date:         Mon, 20 Aug 2018 18:06:30 -0400
Reply-To:     Antonina Roll-Mecak <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Antonina Roll-Mecak <[log in to unmask]>
Subject:      Senior Scientist position in cryo-EM
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--000000000000c19d960573e51fda
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We are currently seeking an outstanding individual to join our team as
Senior Scientist in Cryo-Electron Microscopy at the National Institute of
Neurological Disorders and Stroke in Bethesda. The successful candidate
will join a multidisciplinary group with expertise in molecular biology,
protein biochemistry, X-Ray crystallography and high-resolution
fluorescence microscopy with a mission to provide molecular insights into
important cytoskeletal regulators. The lab has regular access to a
state-of-the art cryo-EM facility which includes a Titan Krios with a K2
direct electron detector with energy filter and will soon add a 200 kV
Talos Arctica.

The Senior Scientist will:

   - Bring innovative structural biology technologies, with a focus on
   cryo-EM as a method for novel protein structure determination
   - Design and conduct experiments for all aspects of structure
   determination by Cryo-EM, including grid preparation, data collection and
   processing and 3-D model building.
   - Work closely with molecular biologists, protein scientists,
   biophysicists as part of an integrated structural biology effort
   - Interface with the central trans-NIH cryo-EM facility for optimal data
   collection strategies
   - Training, assisting and overseeing scientists in the group in sample
   preparation for cryo-EM, data collection and image processing
   - Contribute to the strategic planning of our group in cryo-EM


*Qualifications*

   - A minimum of a Ph.D. or equivalent is required
   - Postdoctoral experience in structural biology or related field is
   required
   - A minimum of 3 years of research experience in single particle
   cryo-electron microscopy in industry or an academic institution is required
   - Deep scientific expertise in structural biology and high-resolution
   structure determination is required
   - Strong record of external publications and presentations is required
   - Experience in scientific programming and ability to work with the
   latest relevant software packages
   - Experience in cryo-electron tomography a plus
   - Skills in working and communicating with scientists at all levels


Salary and benefits are generous and commensurate with research experience
and accomplishments. The DC area is a great place to live with access to
many cultural and outdoors activities. NINDS offers a rich and diverse
scientific environment and the resources on campus are unparalleled. More
information can be found at: https://neuroscience.nih.gov/ninds/rm_lab/
and https://neuroscience.nih.gov/ninds/Home.aspx



To apply: Please send a cover letter, curriculum vitae, bibliography, a
one-page statement of research experience relevant to this position and the
names of three references to Dr. Antonina Roll-Mecak ( [log in to unmask] )
Applications will be considered until December 1, 2018.


--


Antonina Roll-Mecak

Senior Investigator and Chief

Cell Biology and Biophysics Unit

Porter Neuroscience Research Center

NINDS and NHLBI

National Institutes of Health



Administrative contact: Karen Kendrick; Ph: 301-451-9223; Email:
[log in to unmask] <[log in to unmask]>

Lab website: https://neuroscience.nih.gov/ninds/RM_Lab/

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<div dir="ltr"><p class="MsoNormal" style="margin:0in 0in 12pt;text-align:justify;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica;color:black">We are
currently seeking an outstanding individual to join our team as Senior Scientist
in Cryo-Electron Microscopy at the National Institute of Neurological Disorders
and Stroke in Bethesda. The successful candidate will join a multidisciplinary
group with expertise in molecular biology, protein biochemistry, X-Ray
crystallography and high-resolution fluorescence microscopy with a mission to
provide molecular insights into important cytoskeletal regulators. The lab has
regular access to a state-of-the art cryo-EM facility which includes a Titan
Krios with a K2 direct electron detector with energy filter and will soon add a
</span><span style="font-size:10pt;font-family:Helvetica">200 kV Talos
Arctica</span><span style="font-size:10pt;font-family:Helvetica;color:black">. </span></p>

<p class="MsoNormal" style="margin:0in 0in 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;;color:black">The
Senior Scientist will:</span></p>

<ul type="disc" style="margin-bottom:0in">
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;">Bring innovative
     structural biology technologies, with a focus on cryo-EM as a method for
     novel protein structure determination </span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;">Design and
     conduct experiments for all aspects of structure determination by Cryo-EM,
     including grid preparation, data collection and processing and 3-D model
     building.</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;">Work closely
     with molecular biologists, protein scientists, biophysicists as part of an
     integrated structural biology effort</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;">Interface with
     the central trans-NIH cryo-EM facility for optimal data collection
     strategies</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;">Training,
     assisting and overseeing scientists in the group in sample preparation for
     cryo-EM, data collection and image processing </span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;">Contribute to
     the strategic planning of our group in cryo-EM</span></li>
</ul>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:&quot;Helvetica Neue&quot;;color:black"><br>
<b><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Qualifications</span></b></span><span style="font-family:&quot;Times New Roman&quot;"></span></p>

<ul type="disc" style="margin-bottom:0in">
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">A minimum of a Ph.D.
     or equivalent is required</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Postdoctoral
     experience in structural biology or related field is required</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">A minimum of 3
     years of research experience in single particle cryo-electron microscopy
     in industry or an academic institution is required</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Deep scientific
     expertise in structural biology and high-resolution structure
     determination is required</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Strong record of
     external publications and presentations is required</span></li>
 <li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Experience in
     scientific programming and ability to work with the latest relevant
     software packages </span></li><li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Experience in cryo-electron tomography a plus<br></span></li><li class="MsoNormal" style="color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Skills in working and communicating with scientists at all levels<br></span></li>
</ul>

<p class="m_4639653061988231446m_-6097113148842438911m_-7778367007246453296m_2719995462033811647gmail-MsoListParagraphCxSpFirst" style="line-height:11.65pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0in 0in 0.0001pt 0.5in;font-size:12pt;font-family:Calibri"><br></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">Salary and benefits are generous and commensurate with research
experience and accomplishments. The DC area is a great place to live with access
to many cultural and outdoors activities. NINDS offers a rich and diverse
scientific environment and the resources on campus are unparalleled. More information
can be found at: </span><span class="m_4639653061988231446m_-6097113148842438911m_-7778367007246453296m_2719995462033811647gmail-MsoHyperlink" style="color:rgb(5,99,193);text-decoration-line:underline"><span style="font-size:10pt;font-family:Helvetica"><a href="https://neuroscience.nih.gov/ninds/rm_lab/" style="color:rgb(5,99,193)" target="_blank">https://neuroscience.nih.gov/ninds/rm_lab/</a></span></span><span style="font-size:10pt;font-family:Helvetica">  and <a href="https://neuroscience.nih.gov/ninds/Home.aspx" target="_blank">https://neuroscience.nih.gov/ninds/Home.aspx</a></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica">To apply: Please send a cover letter, curriculum vitae,
bibliography, a one-page statement of research experience relevant to this position </span><span style="font-family:Helvetica;font-size:10pt">and the names of three references to Dr. Antonina Roll-Mecak ( </span><a href="mailto:[log in to unmask]" style="font-family:Helvetica;font-size:10pt" target="_blank">[log in to unmask]</a><span style="font-family:Helvetica;font-size:10pt"> ) Applications will be considered </span><span style="font-family:Helvetica;font-size:10pt">until December 1, 2018. </span></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-size:10pt;font-family:Helvetica"></span></p><div><br></div>-- <br><div dir="ltr" class="m_4639653061988231446m_-6097113148842438911m_-7778367007246453296m_2719995462033811647m_-3486125377861995056gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial"><br>Antonina Roll-Mecak</span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial"><span>Senior Investigator and Chief</span></span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial">Cell Biology and Biophysics Unit</span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-family:arial;font-size:9.5pt">Porter Neuroscience Research Center</span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial">NINDS and NHLBI</span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial">National Institutes of Health</span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial"> </span></p><p style="font-size:12.8px"><span style="font-size:9.5pt;font-family:arial"><span>Administrative</span> <span>contact</span>: Karen Kendrick; Ph: 301-451-9223; Email: <a href="mailto:[log in to unmask]" style="color:rgb(17,85,204)" target="_blank">[log in to unmask]</a></span><span style="font-size:10pt;font-family:times"></span></p><p style="margin-bottom:0.0001pt;font-size:12.8px;background-image:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:arial">Lab website: <a href="https://neuroscience.nih.gov/ninds/RM_Lab/" style="color:rgb(17,85,204)" target="_blank">https://neuroscience.nih.gov/ninds/RM_Lab/</a></span></p><p style="font-size:12.8px"> </p></div></div></div></div></div></div>
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--000000000000c19d960573e51fda--
========================================================================Date:         Tue, 21 Aug 2018 15:51:47 +0100
Reply-To:     Roger Williams <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Roger Williams <[log in to unmask]>
Subject:      Postdoctoral position
Mime-Version: 1.0
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Dear all,

A position is available for a postdoctoral researcher I within the Group of Dr Roger Williams at the MRC Laboratory of Molecular Biology (LMB) in Cambridge UK. The research programme aims at understanding structural mechanisms of regulation of the mechanistic target of rapamycin (mTOR) complexes. Specifically,  the work will undertake investigate the structures and regulation of the mTORC1 complex assembled with its regulators on lysosomal membranes.

The work will include large scale mammalian cell culture, cryo-electron microscopy; X-ray crystallography; hydrogen-deuterium exchange mass spectrometry; biophysical measurements of assembly on membranes by confocal microscopy, flow cytometry and single-molecule fluorescence; and enzyme assays. Candidates should have an interest in structural biology and prior experience in one or more of the following techniques: cryo-electron microscopy, X-ray crystallography, enzyme kinetics, mass spectrometry or biochemistry of signal transduction.

To apply for the position, see our advert in the recruiting page at the MRC Laboratory of Molecular Biology. Closing date 2nd Sep, 2018

https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/891-Postdoctoral-Scientist-PNAC-Dr-Roger-Williams-LMB-891/en-GB

For more details, please contact Roger Williams, [log in to unmask]

Group web page: https://www2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/roger-williams/

Thanks

Roger Williams

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========================================================================Date:         Tue, 21 Aug 2018 17:47:50 +0100
Reply-To:     Anindio Sen <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Anindio Sen <[log in to unmask]>
Subject:      switching star files from BSOFT to RELION
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Dear All,

Is there any command / method to switch the star files (formats) from Bsoft to Relion?

Thanks 

Andy



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========================================================================Date:         Tue, 21 Aug 2018 18:09:43 +0100
Reply-To:     Nikos Pinotsis <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Nikos Pinotsis <[log in to unmask]>
Subject:      LocScale through ccpem error
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Hi all,

I am trying to run LocScale through the ccpem gui. The job fails in the
refmac stage because I have some ligands in the structure and there is
no option to add them in the setup. Is there a way to bypass this
problem without editing the pdb?

(I didn't have this problem when I run LocScale from the command line
using phenix.python).

many thanks in advance

Nikos

--
Dr. Nikos Pinotsis
Institute of Structural and Molecular Biology
Department of Biological Sciences, Room B55
Birkbeck College
Malet Street
London WC1E 7HX
T: +44 (0)207 631 6835
M: +44 (0)792 384 3593

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========================================================================Date:         Tue, 21 Aug 2018 20:29:06 +0100
Reply-To:     Zhubing Shi <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Zhubing Shi <[log in to unmask]>
Subject:      Problem during installing Relion 2.0 on OS X 10.13.6
Mime-Version: 1.0
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Message-ID:  <[log in to unmask]>

Hi everyone, 

I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error was reported:

"
[ 46%] Built target run_motioncorr
g++: error: language objective-c++ not recognized
g++: error: language objective-c++ not recognized
make[4]: *** [Fl_cocoa.o] Error 1
make[4]: *** Waiting for unfinished jobs....
Compiling Fl_Quartz_Printer.mm...
[ 49%] Built target reconstruct
[ 50%] Built target particle_symmetry_expand
[ 50%] Built target tiltpair_plot
g++: error: language objective-c++ not recognized
g++: error: language objective-c++ not recognized
make[4]: *** [Fl_Quartz_Printer.o] Error 1
make[3]: *** [all] Error 1
make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-stamp/OWN_FLTK-build] Error 2
make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2
make[1]: *** Waiting for unfinished jobs....
"

I have replaced 'line 122 in external/fltk/src/filename_list.cxx' by:

int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent **))sort);

but it still reported this error. Does anyone know how to fix this problem.

Thanks a lot.

Best,

Zhubing

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========================================================================Date:         Tue, 21 Aug 2018 22:16:40 +0200
Reply-To:     arjen jakobi <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         arjen jakobi <[log in to unmask]>
Subject:      Re: LocScale through ccpem error
Comments: To: [log in to unmask]
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
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--000000000000f024890573f7b48b
Content-Type: text/plain; charset="UTF-8"

Dear Nikos,

thanks for reporting this. Indeed there is currently no option to supply an
additional CIF file via the CCP-EM GUI. I will add this.

However, assuming the ligand you refer to is a small molecule ligand I
believe there will be no noticable difference in the LocScale map whether
or not this ligand is present in your reference structure. LocScale scales
the experimental density using reference amplitudes rotationally averaged
over a rolling window, and provided you chose this sufficiently large the
contribution of the ligand will be marginal.

So one workaround for you would be to simply run LocScale in the CCP-EM GUI
with a reference PDB omitting the ligand (which I assume is not in the
Refmac monomer library), or resorting to the command line version where you
can provide any additional CIF.

Best,
Arjen

On Tue, 21 Aug 2018 at 19:20, Nikos Pinotsis <
[log in to unmask]> wrote:

> Hi all,
>
> I am trying to run LocScale through the ccpem gui. The job fails in the
> refmac stage because I have some ligands in the structure and there is
> no option to add them in the setup. Is there a way to bypass this
> problem without editing the pdb?
>
> (I didn't have this problem when I run LocScale from the command line
> using phenix.python).
>
> many thanks in advance
>
> Nikos
>
> --
> Dr. Nikos Pinotsis
> Institute of Structural and Molecular Biology
> Department of Biological Sciences, Room B55
> Birkbeck College
> Malet Street
> London WC1E 7HX
> T: +44 (0)207 631 6835
> M: +44 (0)792 384 3593
>
> ########################################################################
>
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1
>

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--000000000000f024890573f7b48b
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Content-Transfer-Encoding: quoted-printable

<div dir="ltr"><div><div><div><div><div>Dear Nikos,<br><br></div>thanks for reporting this. Indeed there is currently no option to supply an additional CIF file via the CCP-EM GUI. I will add this.<br><br></div>However, assuming the ligand you refer to is a small molecule ligand I believe there will be no noticable difference in the LocScale map whether or not this ligand is present in your reference structure. LocScale scales the experimental density using reference amplitudes rotationally averaged over a rolling window, and provided you chose this sufficiently large the contribution of the ligand will be marginal.<br><br></div>So one workaround for you would be to simply run LocScale in the CCP-EM GUI with a reference PDB omitting the ligand (which I assume is not in the Refmac monomer library), or resorting to the command line version where you can provide any additional CIF.<br><br></div>Best,<br></div>Arjen<br></div><br><div class="gmail_quote"><div dir="ltr">On Tue, 21 Aug 2018 at 19:20, Nikos Pinotsis &lt;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&gt; wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Hi all,<br>
<br>
I am trying to run LocScale through the ccpem gui. The job fails in the <br>
refmac stage because I have some ligands in the structure and there is <br>
no option to add them in the setup. Is there a way to bypass this <br>
problem without editing the pdb?<br>
<br>
(I didn&#39;t have this problem when I run LocScale from the command line <br>
using phenix.python).<br>
<br>
many thanks in advance<br>
<br>
Nikos<br>
<br>
-- <br>
Dr. Nikos Pinotsis<br>
Institute of Structural and Molecular Biology<br>
Department of Biological Sciences, Room B55<br>
Birkbeck College<br>
Malet Street<br>
London WC1E 7HX<br>
T: +44 (0)207 631 6835<br>
M: +44 (0)792 384 3593<br>
<br>
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<br>
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--000000000000f024890573f7b48b--
========================================================================Date:         Tue, 21 Aug 2018 14:17:23 -0700
Reply-To:     "Dr. Clara Cai" <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         "Dr. Clara Cai" <[log in to unmask]>
Subject:      Re: Problem during installing Relion 2.0 on OS X 10.13.6
Comments: To: Zhubing Shi <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
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--0000000000008531f80573f88e69
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Did you choose "Unix makefiles" in CMake?


-Clara
SingleParticle.com

On Tue, Aug 21, 2018 at 12:29 PM, Zhubing Shi <
[log in to unmask]> wrote:

> Hi everyone,
>
> I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error
> was reported:
>
> "
> [ 46%] Built target run_motioncorr
> g++: error: language objective-c++ not recognized
> g++: error: language objective-c++ not recognized
> make[4]: *** [Fl_cocoa.o] Error 1
> make[4]: *** Waiting for unfinished jobs....
> Compiling Fl_Quartz_Printer.mm...
> [ 49%] Built target reconstruct
> [ 50%] Built target particle_symmetry_expand
> [ 50%] Built target tiltpair_plot
> g++: error: language objective-c++ not recognized
> g++: error: language objective-c++ not recognized
> make[4]: *** [Fl_Quartz_Printer.o] Error 1
> make[3]: *** [all] Error 1
> make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-stamp/OWN_FLTK-build] Error 2
> make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2
> make[1]: *** Waiting for unfinished jobs....
> "
>
> I have replaced 'line 122 in external/fltk/src/filename_list.cxx' by:
>
> int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent
> **))sort);
>
> but it still reported this error. Does anyone know how to fix this problem.
>
> Thanks a lot.
>
> Best,
>
> Zhubing
>
> ########################################################################
>
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1
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--0000000000008531f80573f88e69
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<div dir="ltr">Did you choose &quot;Unix makefiles&quot; in CMake? </div><div class="gmail_extra"><br clear="all"><div><div class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><br><div>-Clara</div><div>SingleParticle.com</div></div></div></div>
<br><div class="gmail_quote">On Tue, Aug 21, 2018 at 12:29 PM, Zhubing Shi <span dir="ltr">&lt;<a href="mailto:[log in to unmask]" target="_blank">[log in to unmask]</a>&gt;</span> wrote:<br><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Hi everyone, <br>
<br>
I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error was reported:<br>
<br>
&quot;<br>
[ 46%] Built target run_motioncorr<br>
g++: error: language objective-c++ not recognized<br>
g++: error: language objective-c++ not recognized<br>
make[4]: *** [Fl_cocoa.o] Error 1<br>
make[4]: *** Waiting for unfinished jobs....<br>
Compiling Fl_Quartz_Printer.mm...<br>
[ 49%] Built target reconstruct<br>
[ 50%] Built target particle_symmetry_expand<br>
[ 50%] Built target tiltpair_plot<br>
g++: error: language objective-c++ not recognized<br>
g++: error: language objective-c++ not recognized<br>
make[4]: *** [Fl_Quartz_Printer.o] Error 1<br>
make[3]: *** [all] Error 1<br>
make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-<wbr>stamp/OWN_FLTK-build] Error 2<br>
make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2<br>
make[1]: *** Waiting for unfinished jobs....<br>
&quot;<br>
<br>
I have replaced &#39;line 122 in external/fltk/src/filename_<wbr>list.cxx&#39; by:<br>
<br>
int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent **))sort);<br>
<br>
but it still reported this error. Does anyone know how to fix this problem.<br>
<br>
Thanks a lot.<br>
<br>
Best,<br>
<br>
Zhubing<br>
<br>
##############################<wbr>##############################<wbr>############<br>
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</blockquote></div><br></div>
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--0000000000008531f80573f88e69--
========================================================================Date:         Tue, 21 Aug 2018 22:31:36 +0000
Reply-To:     Zhubing Shi <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Zhubing Shi <[log in to unmask]>
Subject:      Re: Problem during installing Relion 2.0 on OS X 10.13.6
Comments: To: "Dr. Clara Cai" <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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--_000_D7A1FCB91817zhubingshiUTSouthwesternedu_
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<div>
<div>Hi Clara,</div>
<div><br>
</div>
<div>I didn¡¯t choose this. Could you tell me how to use ¡°Unix makefiles¡± in Cmake.</div>
<div><br>
</div>
<div>Many thanks.</div>
<div><br>
</div>
<div>Best,</div>
<div><br>
</div>
<div>Zhubing</div>
<div><br>
</div>
<div>
<div style="font-family: ËÎÌå, sans-serif;">----------------------&nbsp;</div>
<div>
<div name="divtagdefaultwrapper" style="margin: 0px;">
<div name="divtagdefaultwrapper" style="margin: 0px;">Zhubing Shi, Ph.D.</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">Postdoctoral Researcher, Hongtao Yu lab</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">Department of Pharmacology</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">UT Southwestern Medical Center</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">6001 Forest Park Rd., ND7.504</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">Dallas, TX 75390-9041</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">Phone: (469) 610-0499</div>
<div name="divtagdefaultwrapper" style="margin: 0px;">Email:&nbsp;<a href="mailto:[log in to unmask]"><font color="#0096ff">[log in to unmask]</font></a></div>
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<span style="font-weight:bold">·¢¼þÈË: </span>&quot;Dr. Clara Cai&quot; &lt;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&gt;<br>
<span style="font-weight:bold">ÈÕÆÚ: </span>2018Äê8ÔÂ21ÈÕ ÐÇÆÚ¶þ ÏÂÎç4:17<br>
<span style="font-weight:bold">ÖÁ: </span>Zhubing Shi &lt;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&gt;<br>
<span style="font-weight:bold">³­ËÍ: </span>&quot;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&quot; &lt;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&gt;<br>
<span style="font-weight:bold">Ö÷Ìâ: </span>Re: [ccpem] Problem during installing Relion 2.0 on OS X 10.13.6<br>
</div>
<div><br>
</div>
<div>
<div>
<div dir="ltr">Did you choose &quot;Unix makefiles&quot; in CMake?&nbsp;</div>
<div class="gmail_extra"><br clear="all">
<div>
<div class="gmail_signature" data-smartmail="gmail_signature">
<div dir="ltr"><br>
<div>-Clara</div>
<div>SingleParticle.com</div>
</div>
</div>
</div>
<br>
<div class="gmail_quote">On Tue, Aug 21, 2018 at 12:29 PM, Zhubing Shi <span dir="ltr">
&lt;<a href="mailto:[log in to unmask]" target="_blank">[log in to unmask]</a>&gt;</span> wrote:<br>
<blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">
Hi everyone, <br>
<br>
I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error was reported:<br>
<br>
&quot;<br>
[ 46%] Built target run_motioncorr<br>
g&#43;&#43;: error: language objective-c&#43;&#43; not recognized<br>
g&#43;&#43;: error: language objective-c&#43;&#43; not recognized<br>
make[4]: *** [Fl_cocoa.o] Error 1<br>
make[4]: *** Waiting for unfinished jobs....<br>
Compiling Fl_Quartz_Printer.mm...<br>
[ 49%] Built target reconstruct<br>
[ 50%] Built target particle_symmetry_expand<br>
[ 50%] Built target tiltpair_plot<br>
g&#43;&#43;: error: language objective-c&#43;&#43; not recognized<br>
g&#43;&#43;: error: language objective-c&#43;&#43; not recognized<br>
make[4]: *** [Fl_Quartz_Printer.o] Error 1<br>
make[3]: *** [all] Error 1<br>
make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-<wbr>stamp/OWN_FLTK-build] Error 2<br>
make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2<br>
make[1]: *** Waiting for unfinished jobs....<br>
&quot;<br>
<br>
I have replaced 'line 122 in external/fltk/src/filename_<wbr>list.cxx' by:<br>
<br>
int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent **))sort);<br>
<br>
but it still reported this error. Does anyone know how to fix this problem.<br>
<br>
Thanks a lot.<br>
<br>
Best,<br>
<br>
Zhubing<br>
<br>
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--_000_D7A1FCB91817zhubingshiUTSouthwesternedu_--
========================================================================Date:         Wed, 22 Aug 2018 03:00:10 +0100
Reply-To:     Russell Nathan Hyer <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Russell Nathan Hyer <[log in to unmask]>
Subject:      Re: CCPEM Digest - 20 Aug 2018 to 21 Aug 2018 (#2018-207)
In-Reply-To:  <[log in to unmask]>
Content-Type: text/plain; charset="utf-8"
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Hi Zhubing,

Thanks for your question. The reason you're seeing this issue is that whilst the majority of the code that's being compiled is in fact in C++ (which is the superset that also includes C), the FLTK code specifically for compiling this GUI library on the Mac uses objective-C, such that, the superset becomes objective-C++ which includes objective C, C++ and C.

Are you attempting to build fltk using GCC on your Mac or are you using LLVM which is bundled with the Apple developer tools through the app store?

The code that you changed only relates to a functional prototype which is legal in C, C++ and objective C which just says that a function that will occur later on in this program will have this general format (although its exact definition will be specified later on). (However, your definition is already included by default since your compiler will already see that you're on a Mac (unless you've set a switch to compile for another processor) so it will have already applied that patch, so that's why that patch is ineffective for line 121/122)

Russell

> ------------------------------
> 
> Date:    Tue, 21 Aug 2018 20:29:06 +0100
> From:    Zhubing Shi <[log in to unmask]>
> Subject: Problem during installing Relion 2.0 on OS X 10.13.6
> 
> Hi everyone, 
> 
> I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error was reported:
> 
> "
> [ 46%] Built target run_motioncorr
> g++: error: language objective-c++ not recognized
> g++: error: language objective-c++ not recognized
> make[4]: *** [Fl_cocoa.o] Error 1
> make[4]: *** Waiting for unfinished jobs....
> Compiling Fl_Quartz_Printer.mm...
> [ 49%] Built target reconstruct
> [ 50%] Built target particle_symmetry_expand
> [ 50%] Built target tiltpair_plot
> g++: error: language objective-c++ not recognized
> g++: error: language objective-c++ not recognized
> make[4]: *** [Fl_Quartz_Printer.o] Error 1
> make[3]: *** [all] Error 1
> make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-stamp/OWN_FLTK-build] Error 2
> make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2
> make[1]: *** Waiting for unfinished jobs....
> "
> 
> I have replaced 'line 122 in external/fltk/src/filename_list.cxx' by:
> 
> int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent **))sort);
> 
> but it still reported this error. Does anyone know how to fix this problem.
> 
> Thanks a lot.
> 
> Best,
> 
> Zhubing
########################################################################

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========================================================================Date:         Wed, 22 Aug 2018 03:15:16 +0000
Reply-To:     Zhubing Shi <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Zhubing Shi <[log in to unmask]>
Subject:      Re: CCPEM Digest - 20 Aug 2018 to 21 Aug 2018 (#2018-207)
Comments: To: Russell Nathan Hyer <[log in to unmask]>
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QkVEMT1DQ1BFTSZBPTENCg=========================================================================Date:         Wed, 22 Aug 2018 15:58:55 +0900
Reply-To:     =?utf-8?B?66WY67KU7ZWc?= <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         =?utf-8?B?66WY67KU7ZWc?= <[log in to unmask]>
Subject:      Stacker v2 is not working
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Hello, ccpem

I am trying to reduce the file size generated from EPU.

As described in WARP website,
I used stacker v2 to do it.

However, the output from a 1.3G movie has merely 12MB.

Apparently something’s wrong and motion correction with it made all-black micrograph.

Any solution?

Best regards 
Ryu

Bum Han Ryu

Postdoctoral Researcher
Korea Basic Science Institute (KBSI)
161 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si
Chungcheongbuk-do, Republic of Korea

Office) 043-240-5329


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<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body dir="auto"><span style="background-color: rgba(255, 255, 255, 0);">Hello, ccpem</span><div><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0);">I am trying to reduce the file size generated from EPU.</span></div><div><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0);">As described in WARP website,</span></div><div><span style="background-color: rgba(255, 255, 255, 0);">I used stacker v2 to do it.</span></div><div><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0);">However, the output from a 1.3G movie has merely 12MB.</span></div><div><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0);">Apparently something’s wrong and motion correction with it made all-black micrograph.</span></div><div><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0);">Any solution?</span></div><div><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0);">Best regards&nbsp;</span></div><div><span style="background-color: rgba(255, 255, 255, 0);">Ryu<br><br></span><div><div class=""><div dir="auto" class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="" style="font-variant-ligatures: normal; font-variant-position: normal; font-variant-numeric: normal; font-variant-alternates: normal; font-variant-east-asian: normal; line-height: normal; orphans: 2; widows: 2;"><div class="" style="orphans: auto; widows: auto;"><b class="" style="background-color: rgba(255, 255, 255, 0);">Bum Han Ryu</b></div><div class="" style="orphans: auto; widows: auto;"><span style="background-color: rgba(255, 255, 255, 0);"><br class=""></span></div><div class="" style="orphans: auto; widows: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Postdoctoral Researcher</span></div><div class="" style="orphans: auto; widows: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Korea Basic Science Institute (KBSI)</span></div><div class=""><div class="" style="orphans: auto; widows: auto;"><span style="background-color: rgba(255, 255, 255, 0);">161 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si</span></div><div class="" style="orphans: auto; widows: auto;"><span style="background-color: rgba(255, 255, 255, 0);">Chungcheongbuk-do, Republic of Korea</span></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div><div class=""><span style="background-color: rgba(255, 255, 255, 0);"><br class=""></span></div><span style="background-color: rgba(255, 255, 255, 0);">Office)&nbsp;<a href="tel:043-240-5329" dir="ltr" x-apple-data-detectors="true" x-apple-data-detectors-type="telephone" x-apple-data-detectors-result="1">043-240-5329</a></span></div></div></div><div><div class="" style="orphans: auto; widows: auto;"><div class=""><span style="background-color: rgba(255, 255, 255, 0);"><br></span></div></div></div></body></html><br>
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========================================================================Date:         Wed, 22 Aug 2018 09:05:05 +0000
Reply-To:     Daniel Larsson <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Daniel Larsson <[log in to unmask]>
Subject:      Bayesian Polish questions
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L3d3dy5qaXNjbWFpbC5hYy51ay9jZ2ktYmluL3dlYmFkbWluP1NVQkVEMT1DQ1BFTSZBPTENCg=========================================================================Date:         Wed, 22 Aug 2018 10:39:12 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: Bayesian Polish questions
Comments: To: Daniel Larsson <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
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Hi Daniel,

> 1) Does the movie refinement apply the gain correction, as done by the
> motion correction job? There is noting about it in the log and I briefly
> checked the source (particle_polisher.cpp) and could not find any
> reference to the gain.mrc that is written out to the MotionCorr job. If
> not, it would be easy to implement and should be the right way of doing
> it.

Yes, Bayesian Polish applies gain correction.
(but not anisotropic magnification correction, unfortunately.
It is on our TODO list but will not be ready by RELION 3.0)

"particle_polisher.cpp" is the code for old particle polishing, which is
no longer
available from GUI.

> 2) In the previous version, we got per-frame Guinier plots, but not any
> more. So now there is no way to evaluate how good the fits are. How does
> one now estimate the lower bound of the resolution range for per-frame
> B-factor estimation?

Per-frame B factor is estimated in a different way from old Polishing.
Please look at our preprint:
https://www.biorxiv.org/content/early/2018/08/03/384537

Best regards,

Takanori Nakane

> Regards,
> Daniel
>
>
>
>
>
>
>
>
>
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========================================================================Date:         Wed, 22 Aug 2018 10:42:59 +0100
Reply-To:     Russell Nathan Hyer <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Russell Nathan Hyer <[log in to unmask]>
Subject:      Re: CCPEM Digest - 20 Aug 2018 to 21 Aug 2018 (#2018-207)
In-Reply-To:  <[log in to unmask]>
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Hi Zhubing,

Thanks for your email. Well, by definition from my last email:

cmake -DGUI=OFF .. [1]

Will compile on your machine, but you won't have a graphical user interface for the programme to run.

As I still don't know exactly which compiler suite you're using, I'll dust off my Mac later on today and I'll see if I can discover which flag was left out (I have both compilers).

All I meant from my last email was that the graphical library used to provide the graphical interface uses an ever so slightly different computer language when you compile it on the Mac and it affects these 4 files:

Fl_cocoa.mm  Fl_Native_File_Chooser_MAC.mm  Fl_Quartz_Printer.mm  Fl_Sys_Menu_Bar.mm

All of which provide support for MacOS X based windows and other GUI elements. (This is not a Unix issue as such).

Regards

Russell

[1] This assumes you're following these install instructions at:

http://www2.mrc-lmb.cam.ac.uk/relion/index.php?title=Download_%26_install

On Wed, 22 Aug 2018 03:15:16 +0000, Zhubing Shi <[log in to unmask]> wrote:

> Hi Russell,
> 
> Thank you very much for you reply. I am not very familiar with Unix
> system, so I don't totally understand what you have said. Could you
> suggest me how to solve this problem or how to set the parameter for this
> situation.
> 
> Thanks a lot.
> 
> Best,
> 
> Zhubing
> 
> 
> 
> 
> 在 18-8-21 下�9:00， "Russell Nathan Hyer" <[log in to unmask]> 写
> å…¥:
> 
> >Hi Zhubing,
> >
> >Thanks for your question. The reason you're seeing this issue is that
> >whilst the majority of the code that's being compiled is in fact in C++
> >(which is the superset that also includes C), the FLTK code specifically
> >for compiling this GUI library on the Mac uses objective-C, such that,
> >the superset becomes objective-C++ which includes objective C, C++ and C.
> >
> >Are you attempting to build fltk using GCC on your Mac or are you using
> >LLVM which is bundled with the Apple developer tools through the app
> >store?
> >
> >The code that you changed only relates to a functional prototype which is
> >legal in C, C++ and objective C which just says that a function that will
> >occur later on in this program will have this general format (although
> >its exact definition will be specified later on). (However, your
> >definition is already included by default since your compiler will
> >already see that you're on a Mac (unless you've set a switch to compile
> >for another processor) so it will have already applied that patch, so
> >that's why that patch is ineffective for line 121/122)
> >
> >Russell
> >
> >> ------------------------------
> >>
> >> Date:    Tue, 21 Aug 2018 20:29:06 +0100
> >> From:    Zhubing Shi <[log in to unmask]>
> >> Subject: Problem during installing Relion 2.0 on OS X 10.13.6
> >>
> >> Hi everyone,
> >>
> >> I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error
> >>was reported:
> >>
> >> "
> >> [ 46%] Built target run_motioncorr
> >> g++: error: language objective-c++ not recognized
> >> g++: error: language objective-c++ not recognized
> >> make[4]: *** [Fl_cocoa.o] Error 1
> >> make[4]: *** Waiting for unfinished jobs....
> >> Compiling Fl_Quartz_Printer.mm...
> >> [ 49%] Built target reconstruct
> >> [ 50%] Built target particle_symmetry_expand
> >> [ 50%] Built target tiltpair_plot
> >> g++: error: language objective-c++ not recognized
> >> g++: error: language objective-c++ not recognized
> >> make[4]: *** [Fl_Quartz_Printer.o] Error 1
> >> make[3]: *** [all] Error 1
> >> make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-stamp/OWN_FLTK-build] Error 2
> >> make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2
> >> make[1]: *** Waiting for unfinished jobs....
> >> "
> >>
> >> I have replaced 'line 122 in external/fltk/src/filename_list.cxx' by:
> >>
> >> int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent
> >>**))sort);
> >>
> >> but it still reported this error. Does anyone know how to fix this
> >>problem.
> >>
> >> Thanks a lot.
> >>
> >> Best,
> >>
> >> Zhubing
> >########################################################################
> >
> >To unsubscribe from the CCPEM list, click the following link:
> >https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
> 
> 
> ________________________________
> 
> UT Southwestern
> 
> 
> Medical Center
> 
> 
> 
> The future of medicine, today.
> 

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========================================================================Date:         Wed, 22 Aug 2018 15:18:47 +0100
Reply-To:     Russell Nathan Hyer <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Russell Nathan Hyer <[log in to unmask]>
Subject:      Re: CCPEM Digest - 20 Aug 2018 to 21 Aug 2018 (#2018-207)
In-Reply-To:  <[log in to unmask]>
Content-Type: text/plain; charset="utf-8"
Content-Disposition: inline
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Hi Zhubing,

Firstly, there are, of course, other ways to solve this issue[-1]. However, in testing on my Mac I wasn't able to reproduce the issue directly. However, I wasn't using the GCC compiler directly, as my Mac (whilst it also has the GCC installed) defaults to clang which is the compiler collection provided when you install the Apple Developer Tools via the App Store[0]. (I did that for this Mac back in 14, so my version check shows:

Apple LLVM version 7.0.0 (clang-700.0.72)
Target: x86_64-apple-darwin14.5.0
Thread model: posix

and, g++ --version reports:

Configured with: --prefix=/Applications/Xcode.app/Contents/Developer/usr --with-gxx-include-dir=/usr/include/c++/4.2.1
Apple LLVM version 7.0.0 (clang-700.0.72)
Target: x86_64-apple-darwin14.5.0
Thread model: posix

)

So, the system could potentially be updated, but with this version or higher it'll compile ok. (Though, I also installed openmpi, though not all parts of the code make use of that compiler wrapper script for the install).

I tested that I was able to build fltk on its own using this compiler and it worked without issue. If you find that you need additional unix programmes that might be missing by default on your Mac, I find it helpful to use MacPorts [1].

In fact, for the build process I installed cmake and then openmpi support by running these commands in the Terminal:

sudo port install cmake

sudo port install openmpi

sudo port select --set mpi openmpi-mp-fortran

I was able to compile the source without issues just using the cmake instructions given at:

http://www2.mrc-lmb.cam.ac.uk/relion/index.php?title=Download_%26_install

(Ok, so I got several warning messages, but nothing too serious)

Regards

Russell

[-1] For instance, using MacPorts it's possible to install and configure X11, so you don't have to build your GUI for the Mac directly. (Though, this requires a lot more configuration and knowledge of the graphics card, etc, that supports your monitor, etc)

[0] https://developer.apple.com/xcode/ 

[1] https://www.macports.org/

On Wed, 22 Aug 2018 03:15:16 +0000, Zhubing Shi <[log in to unmask]> wrote:

> Hi Russell,
> 
> Thank you very much for you reply. I am not very familiar with Unix
> system, so I don't totally understand what you have said. Could you
> suggest me how to solve this problem or how to set the parameter for this
> situation.
> 
> Thanks a lot.
> 
> Best,
> 
> Zhubing
> 
> 
> 
> 
> 在 18-8-21 下�9:00， "Russell Nathan Hyer" <[log in to unmask]> 写
> å…¥:
> 
> >Hi Zhubing,
> >
> >Thanks for your question. The reason you're seeing this issue is that
> >whilst the majority of the code that's being compiled is in fact in C++
> >(which is the superset that also includes C), the FLTK code specifically
> >for compiling this GUI library on the Mac uses objective-C, such that,
> >the superset becomes objective-C++ which includes objective C, C++ and C.
> >
> >Are you attempting to build fltk using GCC on your Mac or are you using
> >LLVM which is bundled with the Apple developer tools through the app
> >store?
> >
> >The code that you changed only relates to a functional prototype which is
> >legal in C, C++ and objective C which just says that a function that will
> >occur later on in this program will have this general format (although
> >its exact definition will be specified later on). (However, your
> >definition is already included by default since your compiler will
> >already see that you're on a Mac (unless you've set a switch to compile
> >for another processor) so it will have already applied that patch, so
> >that's why that patch is ineffective for line 121/122)
> >
> >Russell
> >
> >> ------------------------------
> >>
> >> Date:    Tue, 21 Aug 2018 20:29:06 +0100
> >> From:    Zhubing Shi <[log in to unmask]>
> >> Subject: Problem during installing Relion 2.0 on OS X 10.13.6
> >>
> >> Hi everyone,
> >>
> >> I am trying to install Relion 2.0 on my Mac Pro (10.13.6), but an error
> >>was reported:
> >>
> >> "
> >> [ 46%] Built target run_motioncorr
> >> g++: error: language objective-c++ not recognized
> >> g++: error: language objective-c++ not recognized
> >> make[4]: *** [Fl_cocoa.o] Error 1
> >> make[4]: *** Waiting for unfinished jobs....
> >> Compiling Fl_Quartz_Printer.mm...
> >> [ 49%] Built target reconstruct
> >> [ 50%] Built target particle_symmetry_expand
> >> [ 50%] Built target tiltpair_plot
> >> g++: error: language objective-c++ not recognized
> >> g++: error: language objective-c++ not recognized
> >> make[4]: *** [Fl_Quartz_Printer.o] Error 1
> >> make[3]: *** [all] Error 1
> >> make[2]: *** [OWN_FLTK-prefix/src/OWN_FLTK-stamp/OWN_FLTK-build] Error 2
> >> make[1]: *** [CMakeFiles/OWN_FLTK.dir/all] Error 2
> >> make[1]: *** Waiting for unfinished jobs....
> >> "
> >>
> >> I have replaced 'line 122 in external/fltk/src/filename_list.cxx' by:
> >>
> >> int n = scandir(dirloc, list, 0, (int(*)(const dirent **, const dirent
> >>**))sort);
> >>
> >> but it still reported this error. Does anyone know how to fix this
> >>problem.
> >>
> >> Thanks a lot.
> >>
> >> Best,
> >>
> >> Zhubing
> >########################################################################
> >
> >To unsubscribe from the CCPEM list, click the following link:
> >https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
> 
> 
> ________________________________
> 
> UT Southwestern
> 
> 
> Medical Center
> 
> 
> 
> The future of medicine, today.
> 

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========================================================================Date:         Wed, 22 Aug 2018 15:33:52 +0000
Reply-To:     Christiane Berger-Schaffitzel
              <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Christiane Berger-Schaffitzel
              <[log in to unmask]>
Subject:      Reminder: Cryo EM specialist for GW4 Cryo-EM Facility at Bristol,
              UK, Deadline: 23 August 2018
Content-Type: multipart/alternative;
              boundary="_000_VI1PR06MB39848A5ABD6A6F2A9EE9D371FE300VI1PR06MB3984eurp_"
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--_000_VI1PR06MB39848A5ABD6A6F2A9EE9D371FE300VI1PR06MB3984eurp_
Content-Type: text/plain; charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable

The GW4 Facility for High-Resolution Electron Cryo-Microscopy based in the Faculty of Life Sciences at the University of Bristol, UK is looking for a cryo EM expert to help run the facility. The GW4 facility is a consortium of 4 Universities (Bath, Bristol, Cardiff, and Exeter) in the SouthWest of the UK serving a thriving research community.

The facility houses a FEI Talos Arctica (200 kV FEG, dedicated cryo EM with autoloader) with a Gatan K2 Bioquantum DED energy filter. Additional TEMs are housed in the Wolfson Bioimaging facility for Light and Electron Microscopy with which there are strong links. In the role as technical expert you will interact with both experienced and novel users and this wide range of users requires good interactive skills and a strong technical background including sample preparation (plunge freezing), negative stain, and ideally also data analysis.



Deadline: 23 August 2018


For further information or an informal chat please contact:

Paul Verkade: [log in to unmask]<mailto:[log in to unmask]>.uk

Christiane Berger-Schaffitzel: [log in to unmask]<mailto:[log in to unmask]>

Judith Mantell: [log in to unmask]<mailto:[log in to unmask]>


Details for Job description (SUPP104305) and applications can be found here: http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=16634&nPostingTargetID=73475&option=28&sort=DESC&respnr=1&ID=Q50FK026203F3VBQBV7V77V83&JobNum=SUPP104305&Resultsperpage=10&lg=UK&mask=uobext




---

Dr Christiane Berger-Schaffitzel
Wellcome Trust Investigator
Professor of Biochemistry
University of Bristol
Biomedical Sciences
University Walk
Bristol, BS8 1TD

Tel:     +44 (0)117 394 1869
Email: [log in to unmask]<mailto:[log in to unmask]>


A top 4 UK university with leading employers (High Fliers 2018)

A top 5 UK university for research (REF 2014)

A top 10 UK university (QS Ranking 2018)

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The&nbsp;<b class="">GW4 Facility for High-Resolution Electron Cryo-Microscopy</b>&nbsp;based in the Faculty of Life Sciences at the University of&nbsp;<b class="">Bristol, UK</b>&nbsp;is looking for a&nbsp;<b class="">cryo EM expert</b>&nbsp;to help run the facility. The GW4 facility is
 a consortium of 4 Universities (Bath, Bristol, Cardiff, and Exeter) in the SouthWest of the UK serving a thriving research community.</p>
<p class="x_MsoNormal" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
The facility houses a FEI Talos Arctica (200 kV FEG, dedicated cryo EM with autoloader) with a Gatan K2 Bioquantum DED energy filter. Additional TEMs are housed in the Wolfson Bioimaging facility for Light and Electron Microscopy with which there are strong
 links. In the role as technical expert you will interact with both experienced and novel users and this wide range of users requires good interactive skills and a strong technical background including sample preparation (plunge freezing), negative stain, and
 ideally also data analysis.</p>
<p class="x_MsoNormal" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
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Deadline: 23 August 2018</p>
<p class="x_MsoNormal" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
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For further information or an informal chat please contact:</p>
<p class="x_MsoNormal" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
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<p class="x_MsoNormal" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
Paul Verkade:&nbsp;<a href="mailto:[log in to unmask]" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" class="">[log in to unmask]</a>.uk</p>
<div class="" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
Christiane Berger-Schaffitzel:&nbsp;<a href="mailto:[log in to unmask]" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" class="">[log in to unmask]</a></div>
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Judith Mantell:&nbsp;<a href="mailto:[log in to unmask]" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" class="">[log in to unmask]</a></p>
<p class="x_MsoNormal" style="color: rgb(33, 33, 33); font-family: wf_segoe-ui_normal, &quot;Segoe UI&quot;, &quot;Segoe WP&quot;, Tahoma, Arial, sans-serif, serif, EmojiFont; font-size: 15px;">
<br>
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Details for Job description (<span class="" style="color: rgb(51, 51, 51);">SUPP104305</span>) and applications can be found here:&nbsp;<font color="#0069d9" class=""><u class=""><a href="http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=16634&amp;nPostingTargetID=73475&amp;option=28&amp;sort=DESC&amp;respnr=1&amp;ID=Q50FK026203F3VBQBV7V77V83&amp;JobNum=SUPP104305&amp;Resultsperpage=10&amp;lg=UK&amp;mask=uobext" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" class="">http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=16634&amp;nPostingTargetID=73475&amp;option=28&amp;sort=DESC&amp;respnr=1&amp;ID=Q50FK026203F3VBQBV7V77V83&amp;JobNum=SUPP104305&amp;Resultsperpage=10&amp;lg=UK&amp;mask=uobext</a></u></font>&nbsp;</p>
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<p style="margin-top:0;margin-bottom:0">---</p>
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<div dir="ltr" style="font-size:12.8px">Dr Christiane Berger-Schaffitzel</div>
<div dir="ltr" style="font-size:12.8px">Wellcome Trust Investigator<br>
Professor of Biochemistry<br>
</div>
<div dir="ltr" style="font-size:12.8px">University of Bristol<br>
Biomedical Sciences<br>
University Walk<br>
Bristol,&nbsp;BS8 1TD<br>
<br>
Tel: &nbsp; &nbsp; &#43;44 (0)117 394 1869<br>
Email: <a href="mailto:[log in to unmask]" target="_blank" id="LPNoLP">
[log in to unmask]</a><br>
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<span style="font-size:9pt; color:black">A top 4 UK university with leading employers (High Fliers 2018)</span></p>
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<span style="font-size:9pt; color:black">A top 5 UK university for research (REF 2014)</span></p>
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<span style="font-size:9pt; color:black">A top 10 UK university (QS Ranking 2018)</span></p>
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--_000_VI1PR06MB39848A5ABD6A6F2A9EE9D371FE300VI1PR06MB3984eurp_--
========================================================================Date:         Wed, 22 Aug 2018 16:59:19 +0000
Reply-To:     Zhubing Shi <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Zhubing Shi <[log in to unmask]>
Subject:      Re: CCPEM Digest - 20 Aug 2018 to 21 Aug 2018 (#2018-207)
Comments: To: Russell Nathan Hyer <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
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bi93ZWJhZG1pbj9TVUJFRDE9Q0NQRU0mQT0xDQo========================================================================Date:         Wed, 22 Aug 2018 11:44:37 -0700
Reply-To:     Sara Weaver <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Sara Weaver <[log in to unmask]>
Subject:      MultiBody Refinement for a particle with symmetry?
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Is there any documentation about using Relion 3 MultiBody Refinement for a
particle with symmetry?  Would applying symmetry violate the assumptions of
the algorithm?

I've run multibody refine from a consensus refinement I did in C1 and
treated the subunits as separate bodies.  I clearly observe continuous
structural heterogeneity, so is applying symmetry to these particles at the
level of consensus refinement inappropriate?

Cheers,
Sara Weaver
--
Sara J. Weaver
*Doctoral Candidate, Jensen Lab*
*California Institute of Technology*

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<div dir="ltr">Is there any documentation about using Relion 3 MultiBody Refinement for a particle with symmetry?  Would applying symmetry violate the assumptions of the algorithm?    <div><br></div><div>I&#39;ve run multibody refine from a consensus refinement I did in C1 and treated the subunits as separate bodies.  I clearly observe continuous structural heterogeneity, so is applying symmetry to these particles at the level of consensus refinement inappropriate?  </div><div><br></div><div>Cheers,</div><div>Sara Weaver </div></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr">Sara J. Weaver<div><div><i>Doctoral Candidate, Jensen Lab</i></div><div><i>California Institute of Technology</i><br></div></div></div></div>
<br>
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--0000000000007c093705740a897c--
========================================================================Date:         Wed, 22 Aug 2018 20:13:51 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: MultiBody Refinement for a particle with symmetry?
Comments: To: Sara Weaver <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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Hi,

Because each subunit moves independently, you have to
run multibody refinement in C1. Since multibody refinement
is continuation from Refine3D, the consensus refinement must
also be carried out in C1.

I know this is limitation in some cases. For example,
each subunit might adapt different orientations, breaking
the symmetry, but they may remain rigid
(i.e. no within-domain deformations). Ideally, the references
for each subset should be common in such cases.

We are working to extend multibody refinement.

Best regards,

Takanori Nakane

On 2018/08/22 19:44, Sara Weaver wrote:
> Is there any documentation about using Relion 3 MultiBody Refinement for a
> particle with symmetry?  Would applying symmetry violate the assumptions of
> the algorithm?
>
> I've run multibody refine from a consensus refinement I did in C1 and
> treated the subunits as separate bodies.  I clearly observe continuous
> structural heterogeneity, so is applying symmetry to these particles at the
> level of consensus refinement inappropriate?
>
> Cheers,
> Sara Weaver
>

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========================================================================Date:         Wed, 22 Aug 2018 12:41:43 -0700
Reply-To:     Basil Greber <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Basil Greber <[log in to unmask]>
Subject:      Re: MultiBody Refinement for a particle with symmetry?
Comments: To: Sara Weaver <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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I‘m not sure if I understand correctly, but would it be possible to apply
symmetry expansion before the C1 refinement? That way you could get the
full signal for your ASU without actually enforcing symmetry.

Best,

Basil

Sara Weaver <[log in to unmask]> schrieb am Mi. 22. Aug. 2018 um 11:45:

> Is there any documentation about using Relion 3 MultiBody Refinement for a
> particle with symmetry?  Would applying symmetry violate the assumptions of
> the algorithm?
>
> I've run multibody refine from a consensus refinement I did in C1 and
> treated the subunits as separate bodies.  I clearly observe continuous
> structural heterogeneity, so is applying symmetry to these particles at the
> level of consensus refinement inappropriate?
>
> Cheers,
> Sara Weaver
> --
> Sara J. Weaver
> *Doctoral Candidate, Jensen Lab*
> *California Institute of Technology*
>
> ------------------------------
>
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
>

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<div><div dir="auto">I‘m not sure if I understand correctly, but would it be possible to apply symmetry expansion before the C1 refinement? That way you could get the full signal for your ASU without actually enforcing symmetry.</div></div><div dir="auto"><br></div><div dir="auto">Best,</div><div dir="auto"><br></div><div dir="auto">Basil</div><div><br><div class="gmail_quote"><div dir="ltr">Sara Weaver &lt;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&gt; schrieb am Mi. 22. Aug. 2018 um 11:45:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="ltr">Is there any documentation about using Relion 3 MultiBody Refinement for a particle with symmetry?  Would applying symmetry violate the assumptions of the algorithm?    <div><br></div><div>I&#39;ve run multibody refine from a consensus refinement I did in C1 and treated the subunits as separate bodies.  I clearly observe continuous structural heterogeneity, so is applying symmetry to these particles at the level of consensus refinement inappropriate?  </div><div><br></div><div>Cheers,</div><div>Sara Weaver </div></div>-- <br><div dir="ltr" class="m_4431516011853536471gmail_signature" data-smartmail="gmail_signature"><div dir="ltr">Sara J. Weaver<div><div><i>Doctoral Candidate, Jensen Lab</i></div><div><i>California Institute of Technology</i><br></div></div></div></div>
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--000000000000a7cbe405740b55eb--
========================================================================Date:         Wed, 22 Aug 2018 15:53:58 -0400
Reply-To:     Oliver Clarke <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Oliver Clarke <[log in to unmask]>
Subject:      Queries re bayesian polishing in Relion 3
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Hi,

I have been playing around with Bayesian polishing in relion 3, and it has already been extremely helpful - up to 0.5 Ã… improvement in one case.

I am now trying to apply it to some other, more challenging cases, and I have a couple of queries that I’m hoping someone more knowledgeable might be able to help out with:

1. I have a dataset from a symmetric protein that is asymmetrically disposed within a nanodisc. In such a case, I get better resolution during refinement by enforcing symmetry, but if I understand correctly the important thing during bayesian polishing is comparison of the projection of the reference map with the aligned particle image. In such a case would I be better using a C1 refinement to start Bayesian polishing, even if it is somewhat lower in resolution?

2. I would like to start polishing from orientations obtained in another package (cryoSPARC in this case). I am assuming that the polishing algorithm is expecting a map that has been calculated in relion, but in certain cases I obtain substantially better resolution in cryoSPARC. In this case, could I just take the cryosparc orientations, calculate two half maps using relion reconstruct, and then use relion_postprocess on those half maps? Or does the refinement itself need to be performed in relion?

3. How important is the training to the final outcome? The optimal parameters for each dataset reported in the preprint are dramatically different. For small, low SNR particles, should we be using more particle images in the training step for optimal results?

4. Not related to Bayesian polishing, but concerning CtfRefine - I have tried this for large particles and got excellent results, but haven’t had the same success with small particles - the datasets I’ve tried so far have given a very large range of per particle defoci with a drop in resolution in refinement afterwards - any tips would be most welcome!

Cheers
Oli

(PS thanks so much for this amazing new set of tools!)
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========================================================================Date:         Thu, 23 Aug 2018 11:22:50 +0300
Reply-To:     Juha Huiskonen <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Juha Huiskonen <[log in to unmask]>
Subject:      Re: MultiBody Refinement for a particle with symmetry?
In-Reply-To:  <[log in to unmask]>
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Dear Sara,

Our localized reconstruction method is suited well to tackle the problem
you describe. It allows you to classify/refine the
symmetry-mismatched/flexible subunits. You can use your Relion 3D
refinement as a starting point. Please see Ilca et al 2015 Nat Commun and
let me know if you need any help.

Best wishes,
Juha

On Wed, Aug 22, 2018 at 10:42 PM Basil Greber <[log in to unmask]>
wrote:

> I‘m not sure if I understand correctly, but would it be possible to apply
> symmetry expansion before the C1 refinement? That way you could get the
> full signal for your ASU without actually enforcing symmetry.
>
> Best,
>
> Basil
>
> Sara Weaver <[log in to unmask]> schrieb am Mi. 22. Aug. 2018 um 11:45:
>
>> Is there any documentation about using Relion 3 MultiBody Refinement for
>> a particle with symmetry?  Would applying symmetry violate the assumptions
>> of the algorithm?
>>
>> I've run multibody refine from a consensus refinement I did in C1 and
>> treated the subunits as separate bodies.  I clearly observe continuous
>> structural heterogeneity, so is applying symmetry to these particles at the
>> level of consensus refinement inappropriate?
>>
>> Cheers,
>> Sara Weaver
>> --
>> Sara J. Weaver
>> *Doctoral Candidate, Jensen Lab*
>> *California Institute of Technology*
>>
>> ------------------------------
>>
>> To unsubscribe from the CCPEM list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
>>
>
> ------------------------------
>
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
>

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<div dir="ltr">Dear Sara,<div><br></div><div>Our localized reconstruction method is suited well to tackle the problem you describe. It allows you to classify/refine the symmetry-mismatched/flexible subunits. You can use your Relion 3D refinement as a starting point. Please see Ilca et al 2015 Nat Commun and let me know if you need any help. </div><div><br></div><div>Best wishes,</div><div>Juha<br></div><br><div class="gmail_quote"><div dir="ltr">On Wed, Aug 22, 2018 at 10:42 PM Basil Greber &lt;<a href="mailto:[log in to unmask]">[log in to unmask]</a>&gt; wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div><div dir="auto">I‘m not sure if I understand correctly, but would it be possible to apply symmetry expansion before the C1 refinement? That way you could get the full signal for your ASU without actually enforcing symmetry.</div></div><div dir="auto"><br></div><div dir="auto">Best,</div><div dir="auto"><br></div><div dir="auto">Basil</div><div><br><div class="gmail_quote"><div dir="ltr">Sara Weaver &lt;<a href="mailto:[log in to unmask]" target="_blank">[log in to unmask]</a>&gt; schrieb am Mi. 22. Aug. 2018 um 11:45:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="ltr">Is there any documentation about using Relion 3 MultiBody Refinement for a particle with symmetry?  Would applying symmetry violate the assumptions of the algorithm?    <div><br></div><div>I&#39;ve run multibody refine from a consensus refinement I did in C1 and treated the subunits as separate bodies.  I clearly observe continuous structural heterogeneity, so is applying symmetry to these particles at the level of consensus refinement inappropriate?  </div><div><br></div><div>Cheers,</div><div>Sara Weaver </div></div>-- <br><div dir="ltr" class="m_6187082111560104555m_4431516011853536471gmail_signature" data-smartmail="gmail_signature"><div dir="ltr">Sara J. Weaver<div><div><i>Doctoral Candidate, Jensen Lab</i></div><div><i>California Institute of Technology</i><br></div></div></div></div>
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--00000000000029a2e3057415f9fe--
========================================================================Date:         Thu, 23 Aug 2018 10:07:31 +0000
Reply-To:     Rebecca Thompson <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Rebecca Thompson <[log in to unmask]>
Subject:      Cryo-EM course at Leeds
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--_000_0D61B4BD42A3411E8E489B511E2BEC06leedsacuk_--
========================================================================Date:         Thu, 23 Aug 2018 13:18:33 +0000
Reply-To:     Tom Burnley - UKRI STFC <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Tom Burnley - UKRI STFC <[log in to unmask]>
Subject:      Re: LocScale through ccpem error
Comments: To: arjen jakobi <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
Content-Type: text/plain; charset="us-ascii"
Content-Transfer-Encoding: quoted-printable
MIME-Version: 1.0
Message-ID:  <[log in to unmask]>

Dear Nikos,


Many thanks for reporting this.  We have added an option for adding ligand dictionary files to LocScale this will be available in the next version.  I will give you instructions offline for testing this function now.


Best wishes,


Tom

________________________________
From: Collaborative Computational Project in Electron cryo-Microscopy <[log in to unmask]> on behalf of arjen jakobi <[log in to unmask]>
Sent: 21 August 2018 21:16:40
To: [log in to unmask]
Subject: Re: [ccpem] LocScale through ccpem error

Dear Nikos,

thanks for reporting this. Indeed there is currently no option to supply an additional CIF file via the CCP-EM GUI. I will add this.

However, assuming the ligand you refer to is a small molecule ligand I believe there will be no noticable difference in the LocScale map whether or not this ligand is present in your reference structure. LocScale scales the experimental density using reference amplitudes rotationally averaged over a rolling window, and provided you chose this sufficiently large the contribution of the ligand will be marginal.

So one workaround for you would be to simply run LocScale in the CCP-EM GUI with a reference PDB omitting the ligand (which I assume is not in the Refmac monomer library), or resorting to the command line version where you can provide any additional CIF.

Best,
Arjen

On Tue, 21 Aug 2018 at 19:20, Nikos Pinotsis <[log in to unmask]<mailto:[log in to unmask]>> wrote:
Hi all,

I am trying to run LocScale through the ccpem gui. The job fails in the
refmac stage because I have some ligands in the structure and there is
no option to add them in the setup. Is there a way to bypass this
problem without editing the pdb?

(I didn't have this problem when I run LocScale from the command line
using phenix.python).

many thanks in advance

Nikos

--
Dr. Nikos Pinotsis
Institute of Structural and Molecular Biology
Department of Biological Sciences, Room B55
Birkbeck College
Malet Street
London WC1E 7HX
T: +44 (0)207 631 6835
M: +44 (0)792 384 3593

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========================================================================Date:         Thu, 23 Aug 2018 18:07:24 +0100
Reply-To:     Nikos Pinotsis <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Nikos Pinotsis <[log in to unmask]>
Subject:      Re: LocScale through ccpem error
Comments: To: Tom Burnley - UKRI STFC <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain; charset=utf-8; format=flowed
Content-Transfer-Encoding: 7bit
Message-ID:  <[log in to unmask]>

Dear Tom,

thanks for the instructions, I managed to go through the Refmac stage,
however I now have an error on the fft stage, because it is using a grid
larger that 364 which is the maximum for fftbig (grid taken from the
cell dimensions and box size of the map). I am not sure how easy it is
to bypass this problem without resizing the initial maps, maybe it is a
task for the future?

all the best

Nikos


Dr. Nikos Pinotsis
Institute of Structural and Molecular Biology
Department of Biological Sciences, Room B55
Birkbeck College
Malet Street
London WC1E 7HX
T: +44 (0)207 631 6835
M: +44 (0)792 384 3593

On 23/08/2018 14:18, Tom Burnley - UKRI STFC wrote:
> Dear Nikos,
>
>
> Many thanks for reporting this.  We have added an option for adding ligand dictionary files to LocScale this will be available in the next version.  I will give you instructions offline for testing this function now.
>
>
> Best wishes,
>
>
> Tom
>
> ________________________________
> From: Collaborative Computational Project in Electron cryo-Microscopy <[log in to unmask]> on behalf of arjen jakobi <[log in to unmask]>
> Sent: 21 August 2018 21:16:40
> To: [log in to unmask]
> Subject: Re: [ccpem] LocScale through ccpem error
>
> Dear Nikos,
>
> thanks for reporting this. Indeed there is currently no option to supply an additional CIF file via the CCP-EM GUI. I will add this.
>
> However, assuming the ligand you refer to is a small molecule ligand I believe there will be no noticable difference in the LocScale map whether or not this ligand is present in your reference structure. LocScale scales the experimental density using reference amplitudes rotationally averaged over a rolling window, and provided you chose this sufficiently large the contribution of the ligand will be marginal.
>
> So one workaround for you would be to simply run LocScale in the CCP-EM GUI with a reference PDB omitting the ligand (which I assume is not in the Refmac monomer library), or resorting to the command line version where you can provide any additional CIF.
>
> Best,
> Arjen
>
> On Tue, 21 Aug 2018 at 19:20, Nikos Pinotsis <[log in to unmask]<mailto:[log in to unmask]>> wrote:
> Hi all,
>
> I am trying to run LocScale through the ccpem gui. The job fails in the
> refmac stage because I have some ligands in the structure and there is
> no option to add them in the setup. Is there a way to bypass this
> problem without editing the pdb?
>
> (I didn't have this problem when I run LocScale from the command line
> using phenix.python).
>
> many thanks in advance
>
> Nikos
>
> --
> Dr. Nikos Pinotsis
> Institute of Structural and Molecular Biology
> Department of Biological Sciences, Room B55
> Birkbeck College
> Malet Street
> London WC1E 7HX
> T: +44 (0)207 631 6835
> M: +44 (0)792 384 3593
>
> ########################################################################
>
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> ________________________________
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========================================================================Date:         Thu, 23 Aug 2018 22:12:36 +0000
Reply-To:     "Min, Xiaoshan" <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         "Min, Xiaoshan" <[log in to unmask]>
Subject:      RELION own Motioncor implementation: Error in askMemory: Memory
              allocation size requested is zero.
MIME-Version: 1.0
Content-Transfer-Encoding: base64
Content-Type: text/plain; charset="utf-8"
Message-ID:  <[log in to unmask]>

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========================================================================Date:         Thu, 23 Aug 2018 18:27:42 -0400
Reply-To:     Oliver Clarke <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Oliver Clarke <[log in to unmask]>
Subject:      Re: Queries re bayesian polishing in Relion 3
In-Reply-To:  <[log in to unmask]>
Content-Type: text/plain; charset=utf-8
Content-Transfer-Encoding: quoted-printable
Mime-Version: 1.0 (Mac OS X Mail 11.5 \(3445.9.1\))
Message-ID:  <[log in to unmask]>

After some playing around I more-or-less partly answered my own queries here - reproducing in case they are of use to anyone else :)

> 1. I have a dataset from a symmetric protein that is asymmetrically disposed within a nanodisc. In such a case, I get better resolution during refinement by enforcing symmetry, but if I understand correctly the important thing during bayesian polishing is comparison of the projection of the reference map with the aligned particle image. In such a case would I be better using a C1 refinement to start Bayesian polishing, even if it is somewhat lower in resolution?
Starting from the symmetric refinement gave the greatest improvement (0.2 Å, 3.3—>3.1). Starting from the asymmetric refinement gave a still noticeable but smaller improvement of 0.1 Å.

> 2. I would like to start polishing from orientations obtained in another package (cryoSPARC in this case). I am assuming that the polishing algorithm is expecting a map that has been calculated in relion, but in certain cases I obtain substantially better resolution in cryoSPARC. In this case, could I just take the cryosparc orientations, calculate two half maps using relion reconstruct, and then use relion_postprocess on those half maps? Or does the refinement itself need to be performed in relion?

Tried a couple of different approaches here. The only one that worked was the following:

1. Convert cryosparc metadata file to star (using pyem)
2. Generate half-stars based on the random subset column of the star file using awk ( e.g. awk ‘$16==1{print}{}’ csparc.star > half1.star)
3. Use relion_reconstruct to generate half maps
4. Run relion_postprocess on the half maps (using the refinement mask from cryosparc, or another similarly generous mask)
5. Run bayesian polishing, and then put the shiny.star back into cryosparc.

What didn’t work:
1. Using cryosparc half maps in step 4 - postprocessing looks fine, but resulting particle tracks are noisy and clearly wrong
2. Using a tighter mask (e.g. the fsc_auto mask from cryosparc) for postprocessing - this gives much better resolution during the postprocessing step, but much worse results for polishing.

Cheers
Oli
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========================================================================Date:         Fri, 24 Aug 2018 02:02:55 +0100
Reply-To:     Amit Singer <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Amit Singer <[log in to unmask]>
Subject:      Job opening
              =?UTF-8?Q?–_Research_Software_Engineer_–_?=Princeton
              University
Mime-Version: 1.0
Content-Transfer-Encoding: quoted-printable
Content-Type: text/plain; charset="UTF-8"
Message-ID:  <[log in to unmask]>

Dear All,
 
We are seeking a research software engineer to lead the development and dissemination of the ASPIRE software package for cryo-EM (http://spr.math.princeton.edu/). 
The research software engineer will be involved in all software life cycle stages (development, optimization, testing, documentation, releasing) of the ASPIRE package and advancing its efficiency, scalability, and functionality. The ideal candidate will have a strong background in scientific programming, academic research, and an interest in computational imaging.
 
Further details and application:
 
https://www.google.com/search?safe=active&q=research+software+engineer&ibp=htl;jobs#fpstate=tldetail&htidocid=DSDhVol13cIAAAAAAAAAAA%3D%3D&htivrt=jobs 

or

https://stackoverflow.com/jobs/200535/research-software-engineer-princeton-university?so=i&pg=1&offset=0&l=princeton&u=Miles&d=20 
 
For informal inquiries please contact Amit Singer ([log in to unmask]) or Yoel Shkolnisky ([log in to unmask]).  
 
Best wishes,
Amit 

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========================================================================Date:         Fri, 24 Aug 2018 06:09:41 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: RELION own Motioncor implementation: Error in askMemory:
              Memory allocation size requested is zero.
Comments: To: "Min, Xiaoshan" <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain; charset=utf-8; format=flowed
Content-Transfer-Encoding: 8bit
Message-ID:  <[log in to unmask]>

Hi,

Please show me the full error log, not just the single line.
What is the width and height of your movies?
Is it in MRC or TIFF?

Best regards,

Takanori Nakane

On 2018/08/23 23:12, Min, Xiaoshan wrote:
> I ran into this error message while doing RELION 3's own Motioncor implementation: Error in askMemory: Memory allocation size requested is zero.  The job is ran on a 4 K80 GPU with 48 core.  RAM is 512 GB.  I have tried different combination of MPI and thread number and always has this error message.  So it should not be out of memory problem.  Even when I ran a test dataset of 20 movies,  the program stops right away. These same movies can be processed in either cisTEM or Shawn's Motioncor2 (via Relion wrapper),  so the movies should not be the problem.   I don’t think I have any setting in my login that will prevent memory allocation for this process.   Does anyone have similar problems? I appreciate any suggestions.
>
> Thanks,
>
> Xiaoshan
>
>
> Xiaoshan Min | Principal Scientist
> Amgen Inc.
> Department of Molecular Engineering
> 1120 Veterans Blvd | South San Francisco, CA
> Ph. 6502442412 | [log in to unmask]
>
>
>
> ########################################################################
>
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========================================================================Date:         Fri, 24 Aug 2018 13:59:04 +0000
Reply-To:     [log in to unmask]
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Beno=?UTF-8?Q?ît_?=Zuber <[log in to unmask]>
Subject:      PhD student position
Comments: To: [log in to unmask]
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aW4/U1VCRUQxPUNDUEVNJkE9MTwvYT4NCjwvcD4NCg=--_000_A459AEF417034EC2ACC119B6FCBA0297anaunibech_--
========================================================================Date:         Fri, 24 Aug 2018 20:38:48 +0200
Reply-To:     Wojtek Galej <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Wojtek Galej <[log in to unmask]>
Subject:      Postdoctoral position in method development for cryo-EM
Comments: cc: [log in to unmask]
MIME-Version: 1.0
Content-Type: text/plain; charset=US-ASCII; format=flowed
Content-Transfer-Encoding: 7bit
Message-ID:  <[log in to unmask]>

Dear All,
A postdoctoral position is available in the team of Florent Cipriani at
the EMBL Grenoble, France. The team specialises in the development of
automated procedures for x-ray crystallography and synchrotron
radiation. We are looking for an ambitious post-doctoral researcher
willing to collaborate with a group of our engineers on the ongoing
project aiming to streamline grid preparation for cryo-EM.
Method developments will be supported by a close collaboration with our
partners at the EMBL Heidelberg (Christoph Muller) and Grenoble (Wojtek
Galej), who will apply newly developed methods to study biological
problems.
For any inquiries, please contact Florent Cipriani: [log in to unmask] or
visit our website:
https://www.embl.fr/research/unit/cipriani/index.html

All the best
Wojtek

--
Dr. Wojciech P. Galej
Group Leader
EMBL Grenoble
71 Avenue des Martyrs
38042 Grenoble Cedex 09
France

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========================================================================Date:         Mon, 27 Aug 2018 09:45:41 +0200
Reply-To:     Dieter Blaas <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Dieter Blaas <[log in to unmask]>
Subject:      Class3D run gets stuck - relion-3-beta1 and -beta2
MIME-Version: 1.0
Content-Type: text/plain; charset=utf-8; format=flowed
Content-Transfer-Encoding: quoted-printable
Message-ID:  <[log in to unmask]>

Dear all,

      please forgive me bringing this up again but I still have no clue 
for the reason for this behavior:

I am running Class3D (4 classes, without alignment) using a 
run_data.star file from a refinement job that converged at 
"_rlnCurrentResolution                       3.699153". The Class3D runs 
fine until "_rlnCurrentResolution                       3.668067", but 
from there onward no output is being generated despite the CPUs 
continuing running at close to 100% for more than 15 hours by now. All 
previous iterations (including maximization) took about 90 min. The last 
output I was:

Maximization ..........................................~~(,_,">

29.50/29.50 min .......................................~~(,_,">

I also tried to modify the run_data.star file by removing some records 
with very high and very low values of _rlnLogLikeliContribution #27 but 
no avail. It always stalls at the above resolution.

I also run the same dataset on another workstation with the same result!

What might be the reason for this? It is very well possible that this is 
the absolute highest resolution attainable with this particular dataset 
but why would relion not continue putting out the same resolution for 
all following iterations?

Thank you very much for hints!

bw Dieter

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: [log in to unmask]
------------------------------------------------------------------------

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========================================================================Date:         Tue, 28 Aug 2018 01:04:13 +0100
Reply-To:     Jing Liu <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Jing Liu <[log in to unmask]>
Subject:      relion2.1 autopicking test error (warning)
Mime-Version: 1.0
Content-Transfer-Encoding: quoted-printable
Content-Type: text/plain; charset="UTF-8"
Message-ID:  <[log in to unmask]>

Hi Dear CCPEM community, 

I am learning relion and am trying to go through the tutorial (2.1). I have encounter a problem when I tried auto-picking 2 micrographs I selected from the tutorial dataset.   (I didn't use gpu acceleration and all other parameters are the same as in the tutorial (eg. 1 MPI processor). ) I saw the same warning on a github post (https://github.com/3dem/relion/issues/171), but I am not sure whether these are related. Could anyone give me some idea of what went wrong and how could I fix the problem? Thank you very much. Below are the warning I saw, and I could not open the result star file. 
 
+ Using (micrograph) pixel size from input STAR file of 3.54 Angstroms
 + Run autopicking on the following micrographs: 
    * MotionCorr/job005/Micrographs/Falcon_2012_06_12-16_44_07_0.mrc
    * MotionCorr/job005/Micrographs/Falcon_2012_06_12-17_14_17_0.mrc
 + WARNING: Requested rescale of micrographs is 690 pixels. The largest prime factor in FFTs is 173
 + WARNING: Will change rescaling of micrographs to 684 pixels, because the prime factor then becomes 19
 + WARNING: add --skip_optimise_scale to your autopick command to prevent rescaling 
 + WARNING: The calculations will be done at a lower resolution than requested.
 Initialising FFTs for the references and masks ... 
   6/   6 sec ............................................................~~(,_,">
 Autopicking ...
  44/  44 sec ............................................................~~(,_,">

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========================================================================Date:         Tue, 28 Aug 2018 11:43:11 +0000
Reply-To:     Maria Elizabeth Falzone <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Maria Elizabeth Falzone <[log in to unmask]>
Subject:      Relion3 beamtilt output "nan"
Content-Type: multipart/alternative;
              boundary="_000_BL0PR06MB4692C80D4BF0EAA5E67F041DF70A0BL0PR06MB4692namp_"
MIME-Version: 1.0
Message-ID:  <[log in to unmask]>

--_000_BL0PR06MB4692C80D4BF0EAA5E67F041DF70A0BL0PR06MB4692namp_
Content-Type: text/plain; charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable

Hello CCPEM!


I have a question about Relion3. I am using it for the first time and when I run the CtfRefine job incluing the option for beam tilt estimation the job says "estimating the beamtilt" but the output file reads "nan" instead of a measurement and there is not error anywhere in the output. Has anyone else experience this or have any idea why? Any information would be greatly appreciated!


Thanks!

-Maria

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--_000_BL0PR06MB4692C80D4BF0EAA5E67F041DF70A0BL0PR06MB4692namp_
Content-Type: text/html; charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable

<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
<style type="text/css" style="display:none;"><!-- P {margin-top:0;margin-bottom:0;} --></style>
</head>
<body dir="ltr">
<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr">
<p style="margin-top:0;margin-bottom:0">Hello CCPEM!</p>
<p style="margin-top:0;margin-bottom:0"><br>
</p>
<p style="margin-top:0;margin-bottom:0">I have a question about Relion3.&nbsp;I am using it for the first time and when I run the CtfRefine job incluing the option for beam tilt estimation the job says&nbsp;&quot;estimating the beamtilt&quot; but the output file reads &quot;nan&quot; instead
 of a measurement and there is not error anywhere in the output. Has anyone else experience this or have any idea why? Any information would be greatly appreciated!</p>
<p style="margin-top:0;margin-bottom:0"><br>
</p>
<p style="margin-top:0;margin-bottom:0">Thanks!</p>
<p style="margin-top:0;margin-bottom:0">-Maria&nbsp;</p>
</div>
</body>
</html>
<br>
<hr>
<p align="center">To unsubscribe from the CCPEM list, click the following link:<br>
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</p>

--_000_BL0PR06MB4692C80D4BF0EAA5E67F041DF70A0BL0PR06MB4692namp_--
========================================================================Date:         Tue, 28 Aug 2018 14:22:38 +0000
Reply-To:     Clemens Grimm <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Clemens Grimm <[log in to unmask]>
Subject:      Relion3 beta installation issue: cmake FindMPI issue when
              compiling on Ubuntu 18.04
Content-Type: text/plain; charset=utf-8; format=flowed; DelSp=Yes
MIME-Version: 1.0
Content-Disposition: inline
Content-Transfer-Encoding: quoted-printable
Message-ID:  <[log in to unmask]>

Dear All,

I could build the targets for Relion 3.0, however, when doing 'make  
install', I get the error message attached below. It seems that there  
is an issue with the cmake FindMPI module which has been changed with  
version 3.10.0. I am using cmake version 3.10.2.

I wonder whether  up- or downgrading cmake would fix the problem.  
Remarkably, Relion 2.1.0 builds fine on this system.

Has anybody else encountered (and possibly solved) this? What cmake  
versions are reported to run fine?

Best,
Clemens



cmake error message:


-- BUILD TYPE set to the default type:  'Release'
-- Setting fallback CUDA_ARCH=35
-- CUDA enabled - Building CUDA-accelerated version of RELION
-- Setting cpu precision to double
-- Setting accelerated code precision to single
-- Using cuda wrapper to compile....
-- Cuda version is >= 7.5 and single-precision build, enable double  
usage warning.
-- CMAKE_C_COMPILER : /usr/bin/cc
-- CMAKE_CXX_COMPILER : /usr/bin/c++
-- MPI_C_COMPILER : /usr/bin/mpicc
-- MPI_CXX_COMPILER : /usr/bin/mpicxx
-- CMAKE_CXX_COMPILER_ID : GNU
-- Could NOT find MPI_C (missing: MPI_C_WORKS)
-- Could NOT find MPI_CXX (missing: MPI_CXX_WORKS)
CMake Error at  
/usr/share/cmake-3.10/Modules/FindPackageHandleStandardArgs.cmake:137  
(message):
   Could NOT find MPI (missing: MPI_C_FOUND MPI_CXX_FOUND)
Call Stack (most recent call first):
    
/usr/share/cmake-3.10/Modules/FindPackageHandleStandardArgs.cmake:378  
(_FPHSA_FAILURE_MESSAGE)
   /usr/share/cmake-3.10/Modules/FindMPI.cmake:1444  
(find_package_handle_standard_args)
   CMakeLists.txt:242 (find_package)


-- Configuring incomplete, errors occurred!
See also "/home/em/relion-3.0_beta/build/CMakeFiles/CMakeOutput.log".
See also "/home/em/relion-3.0_beta/build/CMakeFiles/CMakeError.log".
Makefile:894: recipe for target 'cmake_check_build_system' failed
make: *** [cmake_check_build_system] Error 1


--------------------------------------------------
Dr. Clemens Grimm
Institut für Biochemie
Biozentrum der Universität Würzburg
Am Hubland
D-97074 Würzburg
Germany
e-mail: [log in to unmask]
phone : +49 0931 31 84031
-------------------------------------------------

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========================================================================Date:         Tue, 28 Aug 2018 14:55:56 +0000
Reply-To:     Daniel Larsson <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Daniel Larsson <[log in to unmask]>
Subject:      Re: Relion3 beta installation issue: cmake FindMPI issue when
              compiling on Ubuntu 18.04
Comments: To: Clemens Grimm <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
Content-Type: multipart/alternative;
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========================================================================Date:         Tue, 28 Aug 2018 19:24:25 +0000
Reply-To:     "Renault, L.L.R." <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         "Renault, L.L.R." <[log in to unmask]>
Subject:      cryo-EM NeCEN access
Comments: To: "[log in to unmask]" <[log in to unmask]>
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              boundary="_000_FE804F2CBABB4634BF32A497657250A7biologyleidenunivnl_"
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--_000_FE804F2CBABB4634BF32A497657250A7biologyleidenunivnl_--
========================================================================Date:         Tue, 28 Aug 2018 20:59:09 +0100
Reply-To:     Keda Zhou <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Keda Zhou <[log in to unmask]>
Subject:      3D reconstruction or modelling for polymer
Mime-Version: 1.0
Content-Transfer-Encoding: quoted-printable
Content-Type: text/plain; charset="UTF-8"
Message-ID:  <[log in to unmask]>

Dear all,
I have a question about the polymer reconstruction.
I got my 3D reconstruction and solved the structure for the monomer (barrel like). Under certain condition, I found those monomers can oligomerize together to form polymer by just aligning in a line. 2D classifications were obtained for each pair of monomer in the polymer. Unfortunately I can only observe the side views of how these monomers stick together. De novo 3D reconstruction failed since it lacked disc- views for the polymer. 
My question is whether there are some ways I can do the reconstruction based on my known monomer structure as well as the 2D classifications for the polymer with only side views.
Thanks in advance.
Cody

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========================================================================Date:         Wed, 29 Aug 2018 08:09:13 +0000
Reply-To:     Clemens Grimm <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Clemens Grimm <[log in to unmask]>
Subject:      Re: Relion3 beta installation issue: cmake FindMPI issue when
              compiling on Ubuntu 18.04
Comments: To: Daniel Larsson <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
Content-Type: text/plain; charset=utf-8; format=flowed; DelSp=Yes
MIME-Version: 1.0
Content-Disposition: inline
Content-Transfer-Encoding: quoted-printable
Message-ID:  <[log in to unmask]>

Thanks again, Daniel for this tip.

The latest version of cmake that works for Relion3 beta seems to be  
3.9.6 as for my tests on Ubuntu 18.04. The changes to FindMPI in later  
versions seem to cause the issue.


Best,
Clemens


Zitat von Daniel Larsson <[log in to unmask]>:

> You need to downgrade to an older cmake version. For me using  
> version 3.5.2 worked, while version 3.10.2 gave the same error that  
> you got (although it works for building relion 2.1).
>
> For your reference, here is the bug ticket:
> https://github.com/3dem/relion/issues/384#issuecomment-413243344
>
> Regards,
> Daniel
>
>
>
>> On 2018-08-28, at 16:22, Clemens Grimm  
>> <[log in to unmask]> wrote:
>>
>> Dear All,
>>
>> I could build the targets for Relion 3.0, however, when doing 'make  
>> install', I get the error message attached below. It seems that  
>> there is an issue with the cmake FindMPI module which has been  
>> changed with version 3.10.0. I am using cmake version 3.10.2.
>>
>> I wonder whether  up- or downgrading cmake would fix the problem.  
>> Remarkably, Relion 2.1.0 builds fine on this system.
>>
>> Has anybody else encountered (and possibly solved) this? What cmake  
>> versions are reported to run fine?
>>
>> Best,
>> Clemens
>>
>>
>>
>> cmake error message:
>>
>>
>> -- BUILD TYPE set to the default type:  'Release'
>> -- Setting fallback CUDA_ARCH=35
>> -- CUDA enabled - Building CUDA-accelerated version of RELION
>> -- Setting cpu precision to double
>> -- Setting accelerated code precision to single
>> -- Using cuda wrapper to compile....
>> -- Cuda version is >= 7.5 and single-precision build, enable double  
>> usage warning.
>> -- CMAKE_C_COMPILER : /usr/bin/cc
>> -- CMAKE_CXX_COMPILER : /usr/bin/c++
>> -- MPI_C_COMPILER : /usr/bin/mpicc
>> -- MPI_CXX_COMPILER : /usr/bin/mpicxx
>> -- CMAKE_CXX_COMPILER_ID : GNU
>> -- Could NOT find MPI_C (missing: MPI_C_WORKS)
>> -- Could NOT find MPI_CXX (missing: MPI_CXX_WORKS)
>> CMake Error at  
>> /usr/share/cmake-3.10/Modules/FindPackageHandleStandardArgs.cmake:137  
>> (message):
>>  Could NOT find MPI (missing: MPI_C_FOUND MPI_CXX_FOUND)
>> Call Stack (most recent call first):
>>   
>> /usr/share/cmake-3.10/Modules/FindPackageHandleStandardArgs.cmake:378  
>> (_FPHSA_FAILURE_MESSAGE)
>>  /usr/share/cmake-3.10/Modules/FindMPI.cmake:1444  
>> (find_package_handle_standard_args)
>>  CMakeLists.txt:242 (find_package)
>>
>>
>> -- Configuring incomplete, errors occurred!
>> See also "/home/em/relion-3.0_beta/build/CMakeFiles/CMakeOutput.log".
>> See also "/home/em/relion-3.0_beta/build/CMakeFiles/CMakeError.log".
>> Makefile:894: recipe for target 'cmake_check_build_system' failed
>> make: *** [cmake_check_build_system] Error 1
>>
>>
>> --------------------------------------------------
>> Dr. Clemens Grimm
>> Institut für Biochemie
>> Biozentrum der Universität Würzburg
>> Am Hubland
>> D-97074 Würzburg
>> Germany
>> e-mail: [log in to unmask]
>> phone : +49 0931 31 84031
>> -------------------------------------------------
>>
>> ########################################################################
>>
>> To unsubscribe from the CCPEM list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1



--------------------------------------------------
Dr. Clemens Grimm
Institut für Biochemie
Biozentrum der Universität Würzburg
Am Hubland
D-97074 Würzburg
Germany
e-mail: [log in to unmask]
phone : +49 0931 31 84031
-------------------------------------------------

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========================================================================Date:         Wed, 29 Aug 2018 14:58:25 +0000
Reply-To:     William Rice <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         William Rice <[log in to unmask]>
Subject:      Re: Relion3 beamtilt output "nan"
Comments: To: Maria Elizabeth Falzone <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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========================================================================Date:         Wed, 29 Aug 2018 16:40:47 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: Relion3 beamtilt output "nan"
Comments: To: William Rice <[log in to unmask]>
Comments: cc: Jasenko Zivanov <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain;charset=iso-2022-jp
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Hi,

The phase error due to the beam tilt is proportional to Cs.
See Eq. 4 of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056894/.
This means that if your Cs is very small (say 0.01), probably you
do not have to refine the beam tilt. It also means that fitting
becomes more difficult, because the beam tilt does not produce
much phase errors.

That being said, the program should not give 'nan'.
I CC-ed this mail to Jasenko, who wrote relion_ctf_refine.

Best regards,

Takanori Nakane

> Hi Maria,
> Was this run on data from Krios2? If so, that is the scope with the Cs
> corrector so the Cs is on the order of a few microns instead of 2.7 mm.
We
> have had strange results when trying to do beam tilt correction with
data
> on this microscope. Does the algorithm rely on having a relative large
(or
> "normal") Cs coefficient?
> Bill
> Sent from my iPhone
> On Aug 28, 2018, at 7:53 AM, Maria Elizabeth Falzone
> <[log in to unmask]<mailto:[log in to unmask]>> wrote:
> Hello CCPEM!
> I have a question about Relion3. I am using it for the first time and
when
> I run the CtfRefine job incluing the option for beam tilt estimation the
> job says "estimating the beamtilt" but the output file reads "nan"
instead
> of a measurement and there is not error anywhere in the output. Has
anyone
> else experience this or have any idea why? Any information would be
> greatly appreciated!
> Thanks!
> -Maria
> ________________________________
> To unsubscribe from the CCPEM list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1
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========================================================================Date:         Wed, 29 Aug 2018 18:25:29 +0200
Reply-To:     Dieter Blaas <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Dieter Blaas <[log in to unmask]>
Subject:      Re: Class3D run gets stuck - relion-3-beta1 and -beta2
In-Reply-To:  <[log in to unmask]>
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I just realized that the below does not happen when running the same 
dataset on relion-2.1.0. In this case output continues and the last 13 
iterations show the same (apparently best possible) resolution of 
3.637500 A.

------------------------------------------------------------------------
Dieter Blaas,
Max F. Perutz Laboratories
Medical University of Vienna,
Inst. Med. Biochem., Vienna Biocenter (VBC),
Dr. Bohr Gasse 9/3,
A-1030 Vienna, Austria,
Tel: 0043 1 4277 61630,
Fax: 0043 1 4277 9616,
e-mail: [log in to unmask]
------------------------------------------------------------------------

Am 27.08.2018 um 09:45 schrieb Dieter Blaas:
> Dear all,
>
>      please forgive me bringing this up again but I still have no clue 
> for the reason for this behavior:
>
> I am running Class3D (4 classes, without alignment) using a 
> run_data.star file from a refinement job that converged at 
> "_rlnCurrentResolution                       3.699153". The Class3D 
> runs fine until "_rlnCurrentResolution                       
> 3.668067", but from there onward no output is being generated despite 
> the CPUs continuing running at close to 100% for more than 15 hours by 
> now. All previous iterations (including maximization) took about 90 
> min. The last output I was:
>
> Maximization ..........................................~~(,_,">
>
> 29.50/29.50 min .......................................~~(,_,">
>
> I also tried to modify the run_data.star file by removing some records 
> with very high and very low values of _rlnLogLikeliContribution #27 
> but no avail. It always stalls at the above resolution.
>
> I also run the same dataset on another workstation with the same result!
>
> What might be the reason for this? It is very well possible that this 
> is the absolute highest resolution attainable with this particular 
> dataset but why would relion not continue putting out the same 
> resolution for all following iterations?
>
> Thank you very much for hints!
>
> bw Dieter
>
> ------------------------------------------------------------------------
> Dieter Blaas,
> Max F. Perutz Laboratories
> Medical University of Vienna,
> Inst. Med. Biochem., Vienna Biocenter (VBC),
> Dr. Bohr Gasse 9/3,
> A-1030 Vienna, Austria,
> Tel: 0043 1 4277 61630,
> Fax: 0043 1 4277 9616,
> e-mail: [log in to unmask]
> ------------------------------------------------------------------------
>
> ########################################################################
>
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========================================================================Date:         Wed, 29 Aug 2018 17:06:23 +0000
Reply-To:     Mark Herzik <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Mark Herzik <[log in to unmask]>
Subject:      RELION 3.0 Bayesian particle polishing and binning questions
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bj9TVUJFRDE9Q0NQRU0mQT0xDQo========================================================================Date:         Wed, 29 Aug 2018 18:05:55 +0000
Reply-To:     Maria Elizabeth Falzone <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Maria Elizabeth Falzone <[log in to unmask]>
Subject:      Re: Relion3 beamtilt output "nan"
Comments: To: Jasenko Zivanov <[log in to unmask]>,
          "[log in to unmask]" <[log in to unmask]>
Comments: cc: Takanori Nakane <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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--_000_BL0PR06MB46920EC19C0B83B09F8DB09EF7090BL0PR06MB4692namp_
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Hi Jasenko,


Thank you very much for your response. Interestingly, I do not have the beamtilt_0.txt file, which was my first indication that there was a problem. The nan I am reading out comes from the beamtilt_iter-fit_class_0.txt  and beamtilt_lin-fit_class_0.txt  files.


As far as I can see there are no pixels in the beamtilt_delta-phase_per-pixel.mrc file with a value of nan. Further, there are no values inside the smooth circle with a larger magnitude than 0.3 and I see no correlation between location and +/- values so it seems that it would not help much anyway.


Thank you very much for your help!


-Maria

________________________________
From: Jasenko Zivanov <[log in to unmask]>
Sent: Wednesday, August 29, 2018 1:37:25 PM
To: [log in to unmask]; Maria Elizabeth Falzone
Cc: Takanori Nakane; [log in to unmask]
Subject: [EXTERNAL] Re: [ccpem] Relion3 beamtilt output "nan"


Hi Bill and Maria,

I agree that beamtilt estimation is probably unnecessary with a Cs
corrector.

That being said, the nan is still surprising.
Nans (not-a-number) arise when undefined mathematical operations are
performed, such as divisions of zero by zero or logarithms of negative
numbers. They are also contagious: any operation that includes a nan
will also produce a nan.

I wonder where the first nan came up.
If you look at your ctf_refine output directory (CtfRefine/job???/), you
should find two text files, beamtilt_0.txt and beamtilt_1.txt.
Do both of them contain the nan?

If so, does the per-pixel fit in the image
beamtilt_delta-phase_per-pixel.mrc contain pixels with a nan value?

This image will also tell you whether a beamtilt fit is necessary.
It shows the most likely phase shift for each image frequency.
It should contain a fairly smooth inside circle and a noise ring outside
with random values between -Pi and +Pi.

If one side of the smooth circle shows a clearly positive value
(something close to 1.0) and the opposite side a negative one, then
correcting for beamtilt will probably increase the resolution. If the
values in the circle are all close to zero until the noise ring begins,
then it certainly won't.


Best regards,
Jasenko





On 08/29/2018 04:40 PM, Takanori Nakane wrote:
> Hi,
>
> The phase error due to the beam tilt is proportional to Cs.
> See Eq. 4 of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056894/.
> This means that if your Cs is very small (say 0.01), probably you
> do not have to refine the beam tilt. It also means that fitting
> becomes more difficult, because the beam tilt does not produce
> much phase errors.
>
> That being said, the program should not give 'nan'.
> I CC-ed this mail to Jasenko, who wrote relion_ctf_refine.
>
> Best regards,
>
> Takanori Nakane
>
>> Hi Maria,
>> Was this run on data from Krios2? If so, that is the scope with the Cs
>> corrector so the Cs is on the order of a few microns instead of 2.7 mm.
> We
>> have had strange results when trying to do beam tilt correction with
> data
>> on this microscope. Does the algorithm rely on having a relative large
> (or
>> "normal") Cs coefficient?
>> Bill
>> Sent from my iPhone
>> On Aug 28, 2018, at 7:53 AM, Maria Elizabeth Falzone
>> <[log in to unmask]<mailto:[log in to unmask]>> wrote:
>> Hello CCPEM!
>> I have a question about Relion3. I am using it for the first time and
> when
>> I run the CtfRefine job incluing the option for beam tilt estimation the
>> job says "estimating the beamtilt" but the output file reads "nan"
> instead
>> of a measurement and there is not error anywhere in the output. Has
> anyone
>> else experience this or have any idea why? Any information would be
>> greatly appreciated!
>> Thanks!
>> -Maria
>> ________________________________
>> To unsubscribe from the CCPEM list, click the following link:
>> https://urldefense.proofpoint.com/v2/url?u=https-3A__www.jiscmail.ac.uk_cgi-2Dbin_webadmin-3FSUBED1-3DCCPEM-26A-3D1&d=DwICJg&c=lb62iw4YL4RFalcE2hQUQealT9-RXrryqt9KZX2qu2s&r=EGy8_wqZ1esS1ocN3GhedzpCk5XBprLGag0p26Z6o7Q&m=ZPfHwMMVvx0SskZJ-PAoE_8DF2QcDmXBxKBguzRxpk8&s=igK2UcCsROTKvdooglQQmLys4FdGrrxmh6fihOxDu3k&e=
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>


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<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
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<body dir="ltr">
<div id="divtagdefaultwrapper" style="font-size:12pt;color:#000000;font-family:Calibri,Helvetica,sans-serif;" dir="ltr">
<p style="margin-top:0;margin-bottom:0">Hi Jasenko,</p>
<p style="margin-top:0;margin-bottom:0"><br>
</p>
<p style="margin-top:0;margin-bottom:0">Thank you very much for your response. Interestingly, I do not have the beamtilt_0.txt file, which was my first indication that there was a problem. The nan I am reading out comes from the&nbsp;<span>beamtilt_iter-fit_class_0.txt&nbsp;
 and&nbsp;<span>beamtilt_lin-fit_class_0.txt&nbsp; files.&nbsp;</span></span></p>
<p style="margin-top:0;margin-bottom:0"><span><span><br>
</span></span></p>
<p style="margin-top:0;margin-bottom:0"><span><span>As far as I can see there are no pixels in the&nbsp;<span>beamtilt_delta-phase_per-pixel.mrc file with a value of nan. Further, there are no values inside the smooth circle with a larger magnitude than 0.3 and
 I see no correlation between location and &#43;/- values so it seems that it would not help much anyway.&nbsp;</span></span></span></p>
<p style="margin-top:0;margin-bottom:0"><span><span><span><br>
</span></span></span></p>
<p style="margin-top:0;margin-bottom:0"><span><span><span>Thank you very much for your help!</span></span></span></p>
<p style="margin-top:0;margin-bottom:0"><span><span><span><br>
</span></span></span></p>
<p style="margin-top:0;margin-bottom:0"><span><span><span>-Maria&nbsp;</span></span></span></p>
</div>
<hr style="display:inline-block;width:98%" tabindex="-1">
<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> Jasenko Zivanov &lt;[log in to unmask]&gt;<br>
<b>Sent:</b> Wednesday, August 29, 2018 1:37:25 PM<br>
<b>To:</b> [log in to unmask]; Maria Elizabeth Falzone<br>
<b>Cc:</b> Takanori Nakane; [log in to unmask]<br>
<b>Subject:</b> [EXTERNAL] Re: [ccpem] Relion3 beamtilt output &quot;nan&quot;</font>
<div>&nbsp;</div>
</div>
<div class="BodyFragment"><font size="2"><span style="font-size:11pt;">
<div class="PlainText"><br>
Hi Bill and Maria,<br>
<br>
I agree that beamtilt estimation is probably unnecessary with a Cs&nbsp; <br>
corrector.<br>
<br>
That being said, the nan is still surprising.<br>
Nans (not-a-number) arise when undefined mathematical operations are&nbsp; <br>
performed, such as divisions of zero by zero or logarithms of negative&nbsp; <br>
numbers. They are also contagious: any operation that includes a nan&nbsp; <br>
will also produce a nan.<br>
<br>
I wonder where the first nan came up.<br>
If you look at your ctf_refine output directory (CtfRefine/job???/), you&nbsp; <br>
should find two text files, beamtilt_0.txt and beamtilt_1.txt.<br>
Do both of them contain the nan?<br>
<br>
If so, does the per-pixel fit in the image&nbsp; <br>
beamtilt_delta-phase_per-pixel.mrc contain pixels with a nan value?<br>
<br>
This image will also tell you whether a beamtilt fit is necessary.<br>
It shows the most likely phase shift for each image frequency.<br>
It should contain a fairly smooth inside circle and a noise ring outside&nbsp; <br>
with random values between -Pi and &#43;Pi.<br>
<br>
If one side of the smooth circle shows a clearly positive value&nbsp; <br>
(something close to 1.0) and the opposite side a negative one, then&nbsp; <br>
correcting for beamtilt will probably increase the resolution. If the&nbsp; <br>
values in the circle are all close to zero until the noise ring begins,&nbsp; <br>
then it certainly won't.<br>
<br>
<br>
Best regards,<br>
Jasenko<br>
<br>
<br>
<br>
<br>
<br>
On 08/29/2018 04:40 PM, Takanori Nakane wrote:<br>
&gt; Hi,<br>
&gt;<br>
&gt; The phase error due to the beam tilt is proportional to Cs.<br>
&gt; See Eq. 4 of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056894/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056894/</a>.<br>
&gt; This means that if your Cs is very small (say 0.01), probably you<br>
&gt; do not have to refine the beam tilt. It also means that fitting<br>
&gt; becomes more difficult, because the beam tilt does not produce<br>
&gt; much phase errors.<br>
&gt;<br>
&gt; That being said, the program should not give 'nan'.<br>
&gt; I CC-ed this mail to Jasenko, who wrote relion_ctf_refine.<br>
&gt;<br>
&gt; Best regards,<br>
&gt;<br>
&gt; Takanori Nakane<br>
&gt;<br>
&gt;&gt; Hi Maria,<br>
&gt;&gt; Was this run on data from Krios2? If so, that is the scope with the Cs<br>
&gt;&gt; corrector so the Cs is on the order of a few microns instead of 2.7 mm.<br>
&gt; We<br>
&gt;&gt; have had strange results when trying to do beam tilt correction with<br>
&gt; data<br>
&gt;&gt; on this microscope. Does the algorithm rely on having a relative large<br>
&gt; (or<br>
&gt;&gt; &quot;normal&quot;) Cs coefficient?<br>
&gt;&gt; Bill<br>
&gt;&gt; Sent from my iPhone<br>
&gt;&gt; On Aug 28, 2018, at 7:53 AM, Maria Elizabeth Falzone<br>
&gt;&gt; &lt;[log in to unmask]&lt;mailto:[log in to unmask]&gt;&gt; wrote:<br>
&gt;&gt; Hello CCPEM!<br>
&gt;&gt; I have a question about Relion3. I am using it for the first time and<br>
&gt; when<br>
&gt;&gt; I run the CtfRefine job incluing the option for beam tilt estimation the<br>
&gt;&gt; job says &quot;estimating the beamtilt&quot; but the output file reads &quot;nan&quot;<br>
&gt; instead<br>
&gt;&gt; of a measurement and there is not error anywhere in the output. Has<br>
&gt; anyone<br>
&gt;&gt; else experience this or have any idea why? Any information would be<br>
&gt;&gt; greatly appreciated!<br>
&gt;&gt; Thanks!<br>
&gt;&gt; -Maria<br>
&gt;&gt; ________________________________<br>
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--_000_BL0PR06MB46920EC19C0B83B09F8DB09EF7090BL0PR06MB4692namp_--
========================================================================Date:         Wed, 29 Aug 2018 18:20:53 +0000
Reply-To:     Craig Yoshioka <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Craig Yoshioka <[log in to unmask]>
Subject:      Re: RELION 3.0 Bayesian particle polishing and binning questions
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bWFpbC5hYy51ay9jZ2ktYmluL3dlYmFkbWluP1NVQkVEMT1DQ1BFTSZBPTENCg=========================================================================Date:         Wed, 29 Aug 2018 19:42:11 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: RELION 3.0 Bayesian particle polishing and binning questions
Comments: To: Mark Herzik <[log in to unmask]>
Comments: cc: Jasenko Zivanov <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain; charset=utf-8; format=flowed
Content-Transfer-Encoding: 8bit
Message-ID:  <[log in to unmask]>

Hi,

Just to make sure, when you re-ran Polishing, did you do the following?

1. Re-extract particles in the desired box size and pixel size
2. Re-refine them
3. Run polishing

Also, what happens if you simply use the default parameters?

Best regards,

Takanori Nakane

On 2018/08/29 18:06, Mark Herzik wrote:
> Hi All,
>
> First, apologies for the long email.
>
> We have a dataset of a small protein (<150 kDa) collected at a fairly high magnification (0.56 Ã…/pixel) that we have been trying to process to its fullest using the new Bayesian particle polishing implementation in RELION 3.0. We have hit a proverbial wall in our processing and are hoping some of our fellow EMists could provide some insights as to how best to proceed.
>
> Implementing Bayesian PP with data that have been binned 2x2 (1.12 Ã…/pixel) using a 384 pixel box size yields robust particle trajectory alignments, nice dose-weighting diagnostics, and yields a 3D reconstruction that is Nyquist limited (2.3 Ã… resolution) without CTF refinement. Great.
>
> However, we are now trying to extract shiny particles with a smaller downsampling (to lower the Nyquist-limiting frequency) and larger box size (to decrease the effects of CTF delocalization, which is quite severe at 0.56 Ã…/pixel and 200 kV) without much success.
>
> What we have tried:
> 1) Polishing the unbinned data or data binned 1.5x1.5 using parameters trained against those data results in very noisy particle trajectories, a poor B-factor and dose-weighting scheme, and a worse resolving reconstruction as a result of these efforts (~2.6 Ã… resolution). Quite surprising given that these steps utilize the same particle stack that resulted in the 2.3 Ã… resolution reconstruction mentioned above.
>
> 2) Polishing the unbinned data or data binned 1.5x1.5 using parameters trained against the binned 2x2 data yields better results than those obtained in scenario 1 but worse than the binned 2x2 data processing in their entirety (~2.5 Ã… resolution versus 2.3 Ã… resolution).
>
> 3) Training the binned 1.5x1.5 data using a small box size (256 pixels, which aids the training step) and then trying to extract the shiny particles with a larger box size (512 pixels) -> RELION crashes with the following error:
>
> ERROR:
> Box size cannot be changed without re-estimating motion - reference pixel size (0.84 A) is not an integral multiple of movie pixel size (0.56 A)!
>
> SO we wonder, is there a protocol currently implemented within RELION 3.0 that can use the particle trajectories from downsampled data (the binned 2x2 data in our case) but then extract the shiny particles using a user-inputted pixel size and box size?
>
> Any and all help will be greatly appreciated.
>
> Thanks,
> -Mark
>
> Laboratory of Dr. Gabriel Lander
> Helen Hay Whitney Foundation Postdoctoral Fellow
> The Scripps Research Institute
> Integrative Structural and Computational Biology
> 10550 N. Torrey Pines Rd. HZ 175L
> La Jolla, CA 92037
> Office: (858) 784-9499
>
>
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========================================================================Date:         Wed, 29 Aug 2018 20:54:55 +0000
Reply-To:     Mark Herzik <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Mark Herzik <[log in to unmask]>
Subject:      Re: RELION 3.0 Bayesian particle polishing and binning questions
Comments: To: Takanori Nakane <[log in to unmask]>
Comments: cc: Jasenko Zivanov <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
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aXNjbWFpbC5hYy51ay9jZ2ktYmluL3dlYmFkbWluP1NVQkVEMT1DQ1BFTSZBPTENCg=========================================================================Date:         Wed, 29 Aug 2018 17:13:56 -0400
Reply-To:     Oliver Clarke <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Oliver Clarke <[log in to unmask]>
Subject:      Re: RELION 3.0 Bayesian particle polishing and binning questions
Comments: To: Takanori Nakane <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
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Hi Takanori - related to this, we have a couple of datasets which otherwise look good but where parameter optimization leads to s_acc or s_div converging to zero (see log attached). Does this mean that parameter optimization has failed?

Cheers
Oli



> On Aug 29, 2018, at 2:42 PM, Takanori Nakane <[log in to unmask]> wrote:
> 
> Hi,
> 
> Just to make sure, when you re-ran Polishing, did you do the following?
> 
> 1. Re-extract particles in the desired box size and pixel size
> 2. Re-refine them
> 3. Run polishing
> 
> Also, what happens if you simply use the default parameters?
> 
> Best regards,
> 
> Takanori Nakane
> 
> On 2018/08/29 18:06, Mark Herzik wrote:
>> Hi All,
>> First, apologies for the long email.
>> We have a dataset of a small protein (<150 kDa) collected at a fairly high magnification (0.56 Ã…/pixel) that we have been trying to process to its fullest using the new Bayesian particle polishing implementation in RELION 3.0. We have hit a proverbial wall in our processing and are hoping some of our fellow EMists could provide some insights as to how best to proceed.
>> Implementing Bayesian PP with data that have been binned 2x2 (1.12 Ã…/pixel) using a 384 pixel box size yields robust particle trajectory alignments, nice dose-weighting diagnostics, and yields a 3D reconstruction that is Nyquist limited (2.3 Ã… resolution) without CTF refinement. Great.
>> However, we are now trying to extract shiny particles with a smaller downsampling (to lower the Nyquist-limiting frequency) and larger box size (to decrease the effects of CTF delocalization, which is quite severe at 0.56 Ã…/pixel and 200 kV) without much success.
>> What we have tried:
>> 1) Polishing the unbinned data or data binned 1.5x1.5 using parameters trained against those data results in very noisy particle trajectories, a poor B-factor and dose-weighting scheme, and a worse resolving reconstruction as a result of these efforts (~2.6 Ã… resolution). Quite surprising given that these steps utilize the same particle stack that resulted in the 2.3 Ã… resolution reconstruction mentioned above.
>> 2) Polishing the unbinned data or data binned 1.5x1.5 using parameters trained against the binned 2x2 data yields better results than those obtained in scenario 1 but worse than the binned 2x2 data processing in their entirety (~2.5 Ã… resolution versus 2.3 Ã… resolution).
>> 3) Training the binned 1.5x1.5 data using a small box size (256 pixels, which aids the training step) and then trying to extract the shiny particles with a larger box size (512 pixels) -> RELION crashes with the following error:
>> ERROR:
>> Box size cannot be changed without re-estimating motion - reference pixel size (0.84 A) is not an integral multiple of movie pixel size (0.56 A)!
>> SO we wonder, is there a protocol currently implemented within RELION 3.0 that can use the particle trajectories from downsampled data (the binned 2x2 data in our case) but then extract the shiny particles using a user-inputted pixel size and box size?
>> Any and all help will be greatly appreciated.
>> Thanks,
>> -Mark
>> Laboratory of Dr. Gabriel Lander
>> Helen Hay Whitney Foundation Postdoctoral Fellow
>> The Scripps Research Institute
>> Integrative Structural and Computational Biology
>> 10550 N. Torrey Pines Rd. HZ 175L
>> La Jolla, CA 92037
>> Office: (858) 784-9499
>> ########################################################################
>> To unsubscribe from the CCPEM list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&A=1
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<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Hi Takanori - related to this, we have a couple of datasets which otherwise look good but where parameter optimization leads to s_acc or s_div converging to zero (see log attached). Does this mean that parameter optimization has failed?<div class=""><br class=""></div><div class="">Cheers</div><div class="">Oli</div><div class=""><br class=""></div><div class=""><img apple-inline="yes" id="E562FBF0-D01D-46A5-B53D-59026115F942" width="513" height="305" src="cid:6FDDE097-2854-4E9F-8155-206D214C4D6C" class=""><br class=""><div><br class=""><blockquote type="cite" class=""><div class="">On Aug 29, 2018, at 2:42 PM, Takanori Nakane &lt;<a href="mailto:[log in to unmask]" class="">[log in to unmask]</a>&gt; wrote:</div><br class="Apple-interchange-newline"><div class=""><div class="">Hi,<br class=""><br class="">Just to make sure, when you re-ran Polishing, did you do the following?<br class=""><br class="">1. Re-extract particles in the desired box size and pixel size<br class="">2. Re-refine them<br class="">3. Run polishing<br class=""><br class="">Also, what happens if you simply use the default parameters?<br class=""><br class="">Best regards,<br class=""><br class="">Takanori Nakane<br class=""><br class="">On 2018/08/29 18:06, Mark Herzik wrote:<br class=""><blockquote type="cite" class="">Hi All,<br class="">First, apologies for the long email.<br class="">We have a dataset of a small protein (&lt;150 kDa) collected at a fairly high magnification (0.56 Ã…/pixel) that we have been trying to process to its fullest using the new Bayesian particle polishing implementation in RELION 3.0. We have hit a proverbial wall in our processing and are hoping some of our fellow EMists could provide some insights as to how best to proceed.<br class="">Implementing Bayesian PP with data that have been binned 2x2 (1.12 Ã…/pixel) using a 384 pixel box size yields robust particle trajectory alignments, nice dose-weighting diagnostics, and yields a 3D reconstruction that is Nyquist limited (2.3 Ã… resolution) without CTF refinement. Great.<br class="">However, we are now trying to extract shiny particles with a smaller downsampling (to lower the Nyquist-limiting frequency) and larger box size (to decrease the effects of CTF delocalization, which is quite severe at 0.56 Ã…/pixel and 200 kV) without much success.<br class="">What we have tried:<br class="">1) Polishing the unbinned data or data binned 1.5x1.5 using parameters trained against those data results in very noisy particle trajectories, a poor B-factor and dose-weighting scheme, and a worse resolving reconstruction as a result of these efforts (~2.6 Ã… resolution). Quite surprising given that these steps utilize the same particle stack that resulted in the 2.3 Ã… resolution reconstruction mentioned above.<br class="">2) Polishing the unbinned data or data binned 1.5x1.5 using parameters trained against the binned 2x2 data yields better results than those obtained in scenario 1 but worse than the binned 2x2 data processing in their entirety (~2.5 Ã… resolution versus 2.3 Ã… resolution).<br class="">3) Training the binned 1.5x1.5 data using a small box size (256 pixels, which aids the training step) and then trying to extract the shiny particles with a larger box size (512 pixels) -&gt; RELION crashes with the following error:<br class="">ERROR:<br class="">Box size cannot be changed without re-estimating motion - reference pixel size (0.84 A) is not an integral multiple of movie pixel size (0.56 A)!<br class="">SO we wonder, is there a protocol currently implemented within RELION 3.0 that can use the particle trajectories from downsampled data (the binned 2x2 data in our case) but then extract the shiny particles using a user-inputted pixel size and box size?<br class="">Any and all help will be greatly appreciated.<br class="">Thanks,<br class="">-Mark<br class="">Laboratory of Dr. Gabriel Lander<br class="">Helen Hay Whitney Foundation Postdoctoral Fellow<br class="">The Scripps Research Institute<br class="">Integrative Structural and Computational Biology<br class="">10550 N. Torrey Pines Rd. HZ 175L<br class="">La Jolla, CA 92037<br class="">Office: (858) 784-9499<br class="">########################################################################<br class="">To unsubscribe from the CCPEM list, click the following link:<br class=""><a href="https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&amp;A=1" class="">https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&amp;A=1</a><br class=""></blockquote><br class="">########################################################################<br class=""><br class="">To unsubscribe from the CCPEM list, click the following link:<br class=""><a href="https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&amp;A=1" class="">https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCPEM&amp;A=1</a><br class=""></div></div></blockquote></div><br class=""></div></body></html><br>
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========================================================================Date:         Wed, 29 Aug 2018 23:04:22 +0100
Reply-To:     Takanori Nakane <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Takanori Nakane <[log in to unmask]>
Subject:      Re: RELION 3.0 Bayesian particle polishing and binning questions
In-Reply-To:  <[log in to unmask]>
MIME-Version: 1.0
Content-Type: text/plain; charset=utf-8; format=flowed
Content-Transfer-Encoding: 8bit
Message-ID:  <[log in to unmask]>

Jasenko is not a member of ccpem and cannot post here,
so I am forwarding this to the list instead.

Takanori

On 2018/08/29 22:34, Jasenko Zivanov wrote:
>
> Hi Mark,
>
> If you were to use the trajectories computed from the 2x2-binned images,
> the program would allow you to extract boxes of arbitrary size. The
> result would still be at 1.12 Ã…/pixel, though, and you are already
> hitting Nyquist there.
>
> The reason we don't currently support changing the box size for
> non-integral pixel-size ratios is that the box size also has to be a
> natural number in movie pixels. For a given box size in
> reference-pixels, a larger box has to be extracted from the movie, and
> then Fourier-cropped to the specified target size. If the size of the
> larger box is not an integral multiple of the size of the smaller box,
> then one could end up having to extract a box of fractional size, which
> isn't possible without resampling.
>
> In your specific case, the numbers would accidentally work out, though:
> In order to obtain a 512-pixel box at 0.84 Ã…/pixel, you would have to
> extract a 768-pixel box from the 0.56 Ã…/pixel movie - which is indeed a
> natural number.
> So, if you like, you could comment out lines 45-51 in
> src/jaz/motion/frame_recombiner.cpp to deactivate this condition, and
> use motion_refine with --comb_box 512.
>
> Alternatively, you could also just pad your reference maps (and the
> mask) to 512 pixels with relion_image_handler (don't forget the --o
> parameter or it will overwrite the input image!), and run motion refine
> with those. This would be probably simpler, but it might produce less
> reliable trajectories (see next sentence).
>
> A word of warning, though: although a larger box does contain more of
> the delocalized higher frequencies, its signal-to-noise ratio is worse
> for the lower frequencies due to the empty space around the molecule.
> This makes both motion estimation and the refinement itself less reliable.
>
> We had the same problem with a tiny protein, gamma-secretase. If the box
> is large enough to contain all of the higher frequencies, then it is
> also mostly empty. In the end, we obtained better results with a box of
> insufficient size - and that dataset was collected on a 300 keV
> microscope, where the delocalization effect is far less severe.
>
> Hope this helps.
>
>
> Best regards,
> Jasenko
>
>
>
>
> On 08/29/2018 07:42 PM, Takanori Nakane wrote:
>> Hi,
>>
>> Just to make sure, when you re-ran Polishing, did you do the following?
>>
>> 1. Re-extract particles in the desired box size and pixel size
>> 2. Re-refine them
>> 3. Run polishing
>>
>> Also, what happens if you simply use the default parameters?
>>
>> Best regards,
>>
>> Takanori Nakane
>>
>> On 2018/08/29 18:06, Mark Herzik wrote:
>>> Hi All,
>>>
>>> First, apologies for the long email.
>>>
>>> We have a dataset of a small protein (<150 kDa) collected at a fairly
>>> high magnification (0.56 Ã…/pixel) that we have been trying to process
>>> to its fullest using the new Bayesian particle polishing
>>> implementation in RELION 3.0. We have hit a proverbial wall in our
>>> processing and are hoping some of our fellow EMists could provide
>>> some insights as to how best to proceed.
>>>
>>> Implementing Bayesian PP with data that have been binned 2x2 (1.12
>>> Ã…/pixel) using a 384 pixel box size yields robust particle trajectory
>>> alignments, nice dose-weighting diagnostics, and yields a 3D
>>> reconstruction that is Nyquist limited (2.3 Ã… resolution) without CTF
>>> refinement. Great.
>>>
>>> However, we are now trying to extract shiny particles with a smaller
>>> downsampling (to lower the Nyquist-limiting frequency) and larger box
>>> size (to decrease the effects of CTF delocalization, which is quite
>>> severe at 0.56 Ã…/pixel and 200 kV) without much success.
>>>
>>> What we have tried:
>>> 1) Polishing the unbinned data or data binned 1.5x1.5 using
>>> parameters trained against those data results in very noisy particle
>>> trajectories, a poor B-factor and dose-weighting scheme, and a worse
>>> resolving reconstruction as a result of these efforts (~2.6 Ã…
>>> resolution). Quite surprising given that these steps utilize the same
>>> particle stack that resulted in the 2.3 Ã… resolution reconstruction
>>> mentioned above.
>>>
>>> 2) Polishing the unbinned data or data binned 1.5x1.5 using
>>> parameters trained against the binned 2x2 data yields better results
>>> than those obtained in scenario 1 but worse than the binned 2x2 data
>>> processing in their entirety (~2.5 Ã… resolution versus 2.3 Ã…
>>> resolution).
>>>
>>> 3) Training the binned 1.5x1.5 data using a small box size (256
>>> pixels, which aids the training step) and then trying to extract the
>>> shiny particles with a larger box size (512 pixels) -> RELION crashes
>>> with the following error:
>>>
>>> ERROR:
>>> Box size cannot be changed without re-estimating motion - reference
>>> pixel size (0.84 A) is not an integral multiple of movie pixel size
>>> (0.56 A)!
>>>
>>> SO we wonder, is there a protocol currently implemented within RELION
>>> 3.0 that can use the particle trajectories from downsampled data (the
>>> binned 2x2 data in our case) but then extract the shiny particles
>>> using a user-inputted pixel size and box size?
>>>
>>> Any and all help will be greatly appreciated.
>>>
>>> Thanks,
>>> -Mark
>>>
>>> Laboratory of Dr. Gabriel Lander
>>> Helen Hay Whitney Foundation Postdoctoral Fellow
>>> The Scripps Research Institute
>>> Integrative Structural and Computational Biology
>>> 10550 N. Torrey Pines Rd. HZ 175L
>>> La Jolla, CA 92037
>>> Office: (858) 784-9499
>>>
>>>
>>> ########################################################################
>>>
>>> To unsubscribe from the CCPEM list, click the following link:
>>> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1ÌPEM&A=1
>>>
>>
>
>

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========================================================================Date:         Fri, 31 Aug 2018 17:28:29 +0200
Reply-To:     "Leandro F. Estrozi" <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         "Leandro F. Estrozi" <[log in to unmask]>
Subject:      Helixplorer
MIME-Version: 1.0
Content-Type: text/plain; charset=utf-8; format=flowed
Content-Transfer-Encoding: quoted-printable
Message-ID:  <[log in to unmask]>

Dear EM-community,

We are thrilled to announce the release of the first version of HELIXPLORER.

HELIXPLORER is a web tool to help with the process of indexing helical
structures (finding the symmetry parameters required to solve their 3D
structures).

If you are interested in helices, whether that be because you would like
to solve a structure or simply to better understand the beautiful theory
behind helical symmetry and fiber diffraction, this tool is for you!

Use it to open a power-spectrum of some class average image and
HELIXPLORER can help with the search for the helical symmetry parameters
that best fit your power-spectrum.

Have fun and enjoy!

http://rico.ibs.fr/helixplorer/

Any suggestions or questions are very much welcome and appreciated.

Best wishes,

Leandro F. Estrozi     (leandro.estrozi at ibs.fr)

PS: Only tested with Firefox v61 and Chrome v68.

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========================================================================Date:         Fri, 31 Aug 2018 20:33:05 +0000
Reply-To:     Charles Bowman <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Charles Bowman <[log in to unmask]>
Subject:      RELION 3 Volta Benchmarks
MIME-Version: 1.0
Content-Type: text/plain; charset=WINDOWS-1252
Content-Transfer-Encoding: quoted-printable
Message-ID:  <[log in to unmask]>

Hello Everyone,

As promised earlier, you can now find my benchmark information comparing the currently available NVIDIA Tesla cards on the Ward lab website.

https://ward.scripps.edu/benchmarks

The data is split into two parts - benchmarks meant to compare GPU speeds, and benchmarks meant to push the hardware to its limits.

I welcome any contributions or additions!  I plan to leave this page up as a growing resource.

Thanks,

Charles

__
Charles Bowman
Bioinformatics Analyst
The Ward Group
The Scripps Research Institute

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========================================================================Date:         Fri, 31 Aug 2018 21:04:28 +0000
Reply-To:     Craig Yoshioka <[log in to unmask]>
Sender:       Collaborative Computational Project in Electron cryo-Microscopy
              <[log in to unmask]>
From:         Craig Yoshioka <[log in to unmask]>
Subject:      Re: RELION 3 Volta Benchmarks
Comments: To: Charles Bowman <[log in to unmask]>
In-Reply-To:  <[log in to unmask]>
Content-Type: text/plain; charset="us-ascii"
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Message-ID:  <[log in to unmask]>

Thanks Charles,

A little saddened by the Volta numbers honestly!  Looks like the 1080 or 1080Ti are still value king as long as your model/data fits in GPU mem.

I'll test our 4 and 8 GPU 1080Ti configs you can throw in.

Cheers,
-Craig


> On Aug 31, 2018, at 1:33 PM, Charles Bowman <[log in to unmask]> wrote:
> 
> Hello Everyone,
> 
> As promised earlier, you can now find my benchmark information comparing the currently available NVIDIA Tesla cards on the Ward lab website.
> 
> https://ward.scripps.edu/benchmarks
> 
> The data is split into two parts - benchmarks meant to compare GPU speeds, and benchmarks meant to push the hardware to its limits.
> 
> I welcome any contributions or additions!  I plan to leave this page up as a growing resource.
> 
> Thanks,
> 
> Charles
> 
> __
> Charles Bowman
> Bioinformatics Analyst
> The Ward Group
> The Scripps Research Institute
> 
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