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MRC IMPACT studentship (3.5 years) *Sex-specific genetic architecture of Idiopathic Pulmonary Fibrosis* Supervisors: Prof Louise Wain (Leicester) & Prof Gisli Jenkins (Nottingham) Student will be based at the University of Leicester. Idiopathic Pulmonary Fibrosis (IPF) is a rare, chronic and progressive lung disease with poor prognosis and limited treatment options. Men are more likely to develop IPF; in 2012 16 males and 9 females for every 100,000 people received a first diagnosis of IPF. Previously published genome-wide association studies [1-6] have identified 18 signals of genetic association with IPF with the most replicated associations being in or near the *MUC5B *and* DSP* genes. However, all of these studies analysed males and females together and sex-specific genetic determinants have not been investigated. The primary aim of this project will be to understand the genetic factors that drive this difference in order to further our understanding of the disease process to aid development of new therapeutic strategies. The student will be based at the University of Leicester within an internationally-recognised respiratory genetic epidemiology group and benefit from close collaborations with leading IPF clinicians and researchers from the UK and USA. A broad training in genetic epidemiology will equip the student for a career in the fast-moving and opportunity-rich field of human disease genetics. Applicants should have a background in bioinformatics, epidemiology, statistics or genetics (or similar), with an aptitude for computing (prior programming experience advantageous but not essential) and a keen interest in how genetics affects human health and disease. Closing date: *Friday 13th July 2018 [NEW deadline]* Interviews: Friday 20th July (Birmingham) To apply, and for more details of the IMPACT scheme, visit: https://www.birmingham.ac.uk/schools/mds-graduate-school/scholarships/mrc-impact/programme.aspx Contact me ([log in to unmask]) for more information. References: 1. Mushiroda et al (2008) J Med Genet 45(10):654-6 2. Seibold et al (2011) N Engl J Med 364(16):1503-12 3. Noth et al (2013) Lancet Respir Med 1(4):309-17 4. Fingerlin et al (2013) Nat Genet 45(6):613-20 5. Fingerlin et al (2016) BMC Genet 17(1):74 6. Allen et al (2017) Lancet Resp Med. 5(11):869-880 You may leave the list at any time by sending the command SIGNOFF allstat to [log in to unmask], leaving the subject line blank. You may leave the list at any time by sending the command SIGNOFF allstat to [log in to unmask], leaving the subject line blank.