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Hi Niki,

Sorry to hear about this sad case.

New publications from the RCPath are included in the President's monthly e-newsletter - this one was noted in the one sent on 4th October 2017.  I'm not sure if you have to opt in to receive these as a fellow, or if non-fellows can register on the mailing list.

Best wishes,

Sarah

________________________________________
From: Clinical biochemistry discussion list <[log in to unmask]> on behalf of Lesley Morgan <[log in to unmask]>
Sent: 04 May 2018 16:03
To: [log in to unmask]
Subject: Re: Friday afternoon case

Hi Niki,

Our Clinical Librarian sends us monthly publication updates from RCPath, Gov.UK, NICE, MHRA. You could contact your library and see if they offer this service. You might also be able to contact RCPath and see if they offer an RSS (Rich Site Summary) feed which will email you when a new publication is out.

The other route would be to have those kinds of publications controlled in your document control system so that they are checked regularly for updates and then when there is an update this is distributed to appropriate staff.

Best wishes,

Lesley


Lesley Morgan  Quality Manager
Clinical Biochemistry  Severn Pathology

Tel: 0117 4148428  Fax: 0117 4148438
Website: www.severnpathology.com

-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Niki Meston
Sent: 04 May 2018 15:35
To: [log in to unmask]
Subject: Friday afternoon case

A 14 year old boy presents to GP with 2 weeks history of lethargy - request form states 'jaundice and lethargy'.
Sample for U&E's, FBC and liver profile received in lab 16:30 on a Friday in April, results electronically transmitted back to GP surgery at 19:00.

Na  122       (<121)
K  6.2           (>6.5)
Urea  18.8    (>30)
Creat  106
Bili  19

This wasn't flagged for 'phoning based on cut-offs from RCPath guidance Nov 2010 on 'Out-of-hours reporting of results requiring urgent clinical attention to primary care' (in brackets above), and the results auto-authorised.

The parents of the boy contacted the OOH service 3 times over the weekend. Results above were available and reviewed, but put down to 'artefactual change' and not repeated, despite the child becoming progressively more unwell.

The child then re-presented to ED on the Monday:

Na  114
K  7.0
Urea  24.7
Creat  150

No prizes for guessing his cortisol at that point was 169 nmol/L with an ACTH of 2817 ng/L (0-46). He was rapidly treated for newly presenting Addison's disease and made a good recovery.

My point is that we only then became aware of the new guidance from RCPath Oct 2017, updating 'phoning limits for children <16 years old in terms of Na, K, urea, creat and Glucose.

We instigated the new guidance within 24 hours of becoming aware of this case; the new cut-off for 'phoning Na at 130 mmol/L (and urea > 10 mmol/L) would have almost certainly lead to a more rapid diagnosis, and so treatment.

Am I missing some way of being advised of new relevant guidance from the RCPath - we have actually been awaiting this guidance for some time?

I hope this case can serve to bring the new guidance to anyone else's attention who has yet to read them.

Dr Niki Meston
Consultant Chemical Pathologist
Salisbury NHS Foundation Trust

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