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Dear experts,

I would like to create a white matter mask in the original MRI space (without having to register it to a standard brain). To do this, I ran FAST but the white matter mask in FAST did not exclude subcortical regions. To exclude subcortical regions, I could run FIRST but FIRST is completed in MNI152 space, is that correct? If this is correct, then how should I create a white matter mask that excludes subcortical regions in FSL?

Thank you for you help.

Beth