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Hi SPM list, I have performed a VBM study using a liberal threshold (p<0.001 with minimum cluster 100 voxels) and found several clusters. Now I would like to do a calculation to examine how many subjects I would need to find these effects with a more stringent correction for multiple comparisons. So basically a sample size calculation, based on the effect size found in this first study. Please let me know if you have any thoughts on how to do this. I could not find much on the SPM list. Thanks in advance for any input. Regards, Mara