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Right-click on the shortcut on your desktop, select "properties", and see what folder it has for "start in". Try changing it to C:/CCP4/6.3/bin/ if it is not. Or add that folder to your path. Perhaps windows has a notion of "current directory" and includes that in the search path, and when you start by clicking an executable in bin directory that is your current directory, but when you start from a shortcut it is not? eab Jayashankar wrote: > Dear all, > > I have a strange behavior of the ccp4 interface. > I have a shortcut icon for my ccp4i on my windows7 desktop, when I open it and try to open the shelxcde module in the > program list it complains about the missing path for the shelx. > > But, but, > when I go to the installation directory C:/CCP4/6.3/bin/ ; and open the windows batch file ccp4i.bat , now after the gui > pops-up now the module shelxcde opens with no complains from the program list. > > the problem is similar with when i try jligand. > > Thanks > > (Jay) > Dr. Jayashankar Selvadurai > Hannover > Germany >