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Nothing prescient about that. The MAD concept was first proposed by Herzberg and Lau in 1967, much before sycnhrotrons were used for protein crystallography. Herzenberg, A. & Lau, H. S. M. (1967) Acta. Crystallogr. 22, 24-28. http://scripts.iucr.org/cgi-bin/paper?S0365110X67000040 The PNAS paper even refers to this article. Ganesh Le 13/03/13 16:46, Jacob Keller a écrit : > Did anyone see this prescient line in the PNAS paper? Seems that the > MAD concept was suggested way back then... > > JPK > > > "While the enhancement of anomalous scattering > has not yet been examined in detail, it is in principle > possible to use data collected at three wavelengths (15) to > completely solve the phase problem. The synchrotron source > is uniquely suited for these applications." > > > >